Yan receives R01 from NIDDK to study higher incidence of end-stage renal disease in minorities

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Dr. Guofen Yan recently received new R01 funding from the National Institute of Diabetes and Digestive and Kidney Diseases. The project will use a rigorous statistical modeling approach to address longstanding clinically-epidemiological phenomena for racial/ethnic minority groups in chronic kidney disease.

The minority groups, especially African Americans and Hispanics, continue to experience 2-3 times higher incidence of end stage renal disease (ESRD) than non-Hispanic whites, but paradoxically have much better survival than whites after reaching ESRD and undergoing dialysis. Understanding this has been hampered by methodological challenges.

This project will develop and utilize multi-state survival analysis, longitudinal analysis, and frailty analysis, and analyze two national incident CKD cohorts—the Veterans Affairs CKD population and the Medicare CKD population—with more than 15 years of follow-up connecting pre-ESRD and ESRD.

This is a multi-institutional collaborative project. Dr. Yan is the PI, and four co-investigators are from University of Virginia, University of Utah, and University of California Los Angeles.