Equipment

Produce preclinical or clinical radiopharmaceuticals on a fully automated platform. Trasis radiosynthesizer

• [¹⁸F]FET – primary brain tumors
•  [¹¹C]Methionine – primary brain tumors – low-grade glioma
•  [¹⁸F]DCFPyl- prostate cancer – PSMA
• [¹⁸F]FAZA – hypoxic tumor microenvironment –predicting  radiation response
• [¹⁸F]Fcholine – metastatic prostate cancer, hepatocellular carcinoma
•  [¹⁸F]FDOPA – LAT1-overexpressing tumors; CNS tumors, dopamine turnover
• [¹⁸F]FLT – head-and-neck tumors, cell proliferation
• [¹⁸F]FMISO – tumor hypoxia status

The list is not meant to be all-inclusive. Trasis is an open platform, thus, we can produce customized research radiopharmaceuticals.

The Elixys Flex/Chem system is an open research platform capable of producing a variety of preclinical and clinical research imaging agents. Because the Flex/Chem is an open platform the tracer capabilities of this system are expansive and the user is encouraged to consult the Core Director for inquiries regarding imaging agent study requests.

• This module provides fully automated purification and formulation functionality that is integrated into the main ELIXYS software

Gamma detection window of 100-4,000 kEv [almost any research isotope (¹⁸F, ¹¹C, ^99mTc, ¹²⁵I, ⁶⁸Ga, ⁸⁹Zr, ⁶⁴Cu, etc.)]

Belt-driven/robotic arm automated system with a shielded internal sample balance

• The machine will tare and weigh empty or full vials and will decay-correct to a specified time
• Data is stored as an excel spreadsheet. Will provide raw counts and also convert to %ID/g or %ID/mL

in vitro radiopharmaceutical binding assays

in vitro radiopharmaceutical accumulation assays

ex vivo tissue biodistribution assays

ex vivo arterial input function

ex vivo metabolite assays

• Eckert & Ziegler (E&Z) Modular Lab is a completely automated synthesis system for routine production of wide variety of [¹¹C]carbon-labeled compounds based on the generation of gas-phase [¹¹C]methyl iodide or [¹¹C]methyl triflate synthesis.