Yuh-Hwa Wang Lab

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At the Yuh-Hwa Wang Lab, with the Department of Biochemistry and Molecular Genetics, our research focus is to understand the structure and function of unusual DNA sequences in living cells, and how these sequences cause genome instability and lead to human diseases.

Human chromosomal fragile sites have been correlated with the chromosomal deletions and gene rearrangements found in many cancers.  Our studies are aimed at understanding the genesis of breakpoints that occur at or near fragile sites during oncogenesis.

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