At the Yuh-Hwa Wang Lab, with the Department of Biochemistry and Molecular Genetics, our research focus is to understand the structure and function of unusual DNA sequences in living cells, and how these sequences cause genome instability and lead to human diseases.
Human chromosomal fragile sites have been correlated with the chromosomal deletions and gene rearrangements found in many cancers. Our studies are aimed at understanding the genesis of breakpoints that occur at or near fragile sites during oncogenesis.
January 2020: Karol Szlachta, Heather Raimer, and Laurey Comeau published their work “CNCC: An analysis tool to determine genome-wide DNA break end structure at single-nucleotide resolution” in BMC Genomics.
June 2020: Karol Szlachta, Sandeep Singh, and Heather Raimer published their work “Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks” in Nucleic Acids Research.
March 2020: Sandeep Singh, Karol Szlachta, and Heather Raimer published their work “Pausing sites of RNA polymerase II on actively transcribed genes are enriched with DNA double-stranded breaks” in Journal of Biological Chemistry.
May 2019: Heather Raimer successfully passes her Ph.D qualifying exam and becomes a Ph.D candidate.
- July 2019: Graduate student Heather Raimer’s CMB Training Grant is renewed for another year.
July 2019: Graduate student Naomi Atkin receives a trainee award from the UVA Cancer Center for her work focusing on assessing individual susceptibility for cancer-causing chromosomal abnormalities by measuring DNA breaks.
October 2019: Naomi Atkin and Heather Raimer co-author the review “Broken By the Cut: A Journey into the Role of Topoisomerase II on DNA Fragility” in Genes.
June 2018: Karol Szlachta, Naomi Atkin, and Ryan Thys published their work on “Alternative DNA secondary structure formation affects RNA polymerase II promoter-proximal pausing in human” in Genome Biology. PMID:30001206.
May 2018: Graduate student Heather Raimer receives the NIH Predoctoral Cell and Molecular Biology Training Grant.