At the Yuh-Hwa Wang Lab, within the Department of Biochemistry and Molecular Genetics, our research focus is to understand the structure and function of unusual DNA sequences in living cells, and how these sequences cause genome instability and lead to human diseases.
We are actively recruiting graduate students, postdoctoral fellows, and lab technicians.
- August 2021: Naomi Atkin and Heather Raimer, with our collaborators Zhenjia Wang and Chongzhi Zang, published their work “Assessing acute myeloid leukemia susceptibility in rearrangement‐driven patients by DNA breakage at topoisomerase II and CCCTC-binding factor/cohensin binding sites” in Genes, Chromosomes and Cancer.
- July 2021: Congratulations to Heather Raimer, a rising 5th year Ph.D. student, for being awarded with a Wagner Fellowship. This fellowship is a tribute to Dr. Robert Wagner’s dedication to student training, his encouragement of young scientists, and his love of UVA.
- July 2021: In collaboration with Patrick Dillon M.D. and Christiana Brenin M.D., our project entitled “Developing a DNA susceptibility test to identify breast cancer patients having high risk for therapy-related acute myeloid leukemia” was awarded with the Thelma R. Swortzel Collaborative Research Award.
- June 2021: We have a publication in Journal of Biological Chemistry entitled “The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation.”
- May 2021: Anna Bartosik won the first prize for her talk “The role of G4R1 helicase and DNA G-quadruplex structures in the formation of DNA double-strand breaks” at the UVA Visiting Student Symposium.
- April 2021: Naomi Atkin successfully defended her PhD Dissertation titled “DNA topoisomerase II, CTCF/cohesin binding, and alternative DNA secondary structure alter genomic stability and affect cancer susceptibility”! She is the first student to take part in the new department tradition of signing the Green Room wall. Congratulations Dr. Atkin!
- March 2021: Heather Raimer and Anna Bartosik won the BMG Departmental T-shirt design contest.
- February 2021: Reem Al-Humadi, a third year neuroscience undergraduate student has received the Harrison Undergraduate Research Award for outstanding research projects to study “Effect of Pyridostatin on G-Quadruplex Structure in Amyotrophic Lateral Sclerosis”. Congratulations, Reem!
- January 2021: Our article “Pausing sites of RNA polymerase II on actively transcribed genes are enriched in DNA double-stranded breaks” has been selected as the representative ‘Gene Regulation’ article for the Journal of Biological Chemistry 2020 retrospective collection called “The year in JBC: 2020”. The associate editors looked through hundreds of papers to come up with what they felt best represented the exciting advances reported in JBC last year. Congratulations to all authors!
In the Wang Lab we believe that science, like all other pursuits, is best achieved when many different viewpoints and ways of thinking are involved. We champion scientific rigor and are committed to a supportive learning environment that promotes equity, diversity, and inclusivity.