Yuh-Hwa Wang Lab

At the Yuh-Hwa Wang Lab, with the Department of Biochemistry and Molecular Genetics, our research focus is to understand the structure and function of unusual DNA sequences in living cells, and how these sequences cause genome instability and lead to human diseases. 

Human chromosomal fragile sites have been correlated with the chromosomal deletions and gene rearrangements found in many cancers.  Our studies are aimed at understanding the genesis of breakpoints that occur at or near fragile sites during oncogenesis.

Christine Lehman’s work published in Carcinogenesis

DNA fragile site breakage as a measure of chemical exposure and predictor of individual susceptibility to form oncogenic rearrangements
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Karol Szlachta, Naomi Atkin, and Ryan Thys Have Work Published in Genome Biology

Alternative DNA secondary structure formation affects RNA polymerase II promoter-proximal pausing in human
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Dr. Wang Contributes to Article on Genome Instability in Cancer Cells

Reducing the expression of dUTPase increases genome stress in cancer
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