Within the Department of Biochemistry and Molecular Genetics, our research focus is to understand the structure and function of unusual DNA sequences in living cells, and how these sequences cause genome instability and lead to human diseases.
In the Wang Lab we believe that science, like all other pursuits, is best achieved when many different viewpoints and ways of thinking are involved. We champion scientific rigor and are committed to a supportive learning environment that promotes equity, diversity, and inclusivity.
- July 2022: We have a publication in Scientific Reports entitled ” Transcription-associated DNA DSBs activate p53 during hiPSC-based neurogenesis.”
- July 2022: Heather Raimer Young presented a talk on “Understanding the role of G-quadruplexes and G4R1 in c9orf72 hexanucleotide repeat expansion-driven ALS” at the Dynamic DNA Structures in Biology Conference in Nova Scotia, Canada
- June 2022: Ania Bartosik, a rising second-year BMG graduate student, has received a UVA Cancer Center Trainee Support Award for her study of “Targeting G-quadruplex Structures as a Novel and Highly Promising Therapeutic Strategy”.
- June 2022: Britney Doan, a second-year undergraduate student has received a College Council Minerva Research Grant for the Summer to study “Pyridostatin’s effect on the viability of cells with G4C2 repeat-driven ALS”, Congratulations, Britney!
- May 2022: Congratulations to Heather Raimer Young for receiving the GBS Student Leadership Award!
- May 2022: Reem Al-Humadi, a 4th year neuroscience undergraduate student, won the top prize for her oral presentation at the Fozdar Symposium on “Effect of Pyridostatin” on Global Gene Transcription in ALS/FTD with c9orf72 Repeat Expansion”.
- April 2022, Heather Raimer Young, a 5th year PhD candidate, was awarded with the Hamlin Lecture Series Award which is given in honor of former BMG Chair, Dr. Joyce Hamlin.
- February 2022: Ania Bartosik, a first-year BIMS graduate student, decided to join our lab. Welcome back, Anna!
- January 2022: Dr. Pei-Chi Hou, a Research Scientist, and Britney Doan, an undergraduate researcher, joined the lab. Welcome aboard!
- November 2021: Heather Raimer and Ania Bartosik gave talks on their work at the Commonwealth of Virginia Cancer Research Conference in Richmond.
- August 2021: Naomi Atkin and Heather Raimer, with our collaborators Zhenjia Wang and Chongzhi Zang, published their work “Assessing acute myeloid leukemia susceptibility in rearrangement‐driven patients by DNA breakage at topoisomerase II and CCCTC-binding factor/cohensin binding sites” in Genes, Chromosomes and Cancer.
- July 2021: Congratulations to Heather Raimer, a rising 5th year Ph.D. student, for being awarded with a Wagner Fellowship. This fellowship is a tribute to Dr. Robert Wagner’s dedication to student training, his encouragement of young scientists, and his love of UVA.
- July 2021: In collaboration with Patrick Dillon M.D. and Christiana Brenin M.D., our project entitled “Developing a DNA susceptibility test to identify breast cancer patients having high risk for therapy-related acute myeloid leukemia” was awarded with the Thelma R. Swortzel Collaborative Research Award.
- June 2021: We have a publication in Journal of Biological Chemistry entitled “The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation.”
- May 2021: Anna Bartosik won the first prize for her talk “The role of G4R1 helicase and DNA G-quadruplex structures in the formation of DNA double-strand breaks” at the UVA Visiting Student Symposium.
- April 2021: Naomi Atkin successfully defended her PhD Dissertation titled “DNA topoisomerase II, CTCF/cohesin binding, and alternative DNA secondary structure alter genomic stability and affect cancer susceptibility”! She is the first student to take part in the new department tradition of signing the Green Room wall. Congratulations Dr. Atkin!
- March 2021: Heather Raimer and Anna Bartosik won the BMG Departmental T-shirt design contest.
- February 2021: Reem Al-Humadi, a third year neuroscience undergraduate student has received the Harrison Undergraduate Research Award for outstanding research projects to study “Effect of Pyridostatin on G-Quadruplex Structure in Amyotrophic Lateral Sclerosis”. Congratulations, Reem!
- January 2021: Our article “Pausing sites of RNA polymerase II on actively transcribed genes are enriched in DNA double-stranded breaks” has been selected as the representative ‘Gene Regulation’ article for the Journal of Biological Chemistry 2020 retrospective collection called “The year in JBC: 2020”. The associate editors looked through hundreds of papers to come up with what they felt best represented the exciting advances reported in JBC last year. Congratulations to all authors!