Publications

Rolland SJ, Lifschin ZJ, Weddle EA, Yum LK, Miyake T, Engel DA, Agaisse HF. Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation. PLoS pathogens. 2025; 21: e1012707. PMID: 40378153

Siff TE, Allen PE, Armistead DL, Hunt JR, Rolland SJ, Agaisse H, Carlyon JA. Orientia tsutsugamushi Modulates RIPK3 Cellular Levels but Does Not Inhibit Necroptosis. Pathogens. 2025 14: 478. PMID: 40430799

Hall CP, Jadeja NB, Sebeck N, Agaisse H. Characterization of MxiE-and H-NS-Dependent Expression of ipaH7. 8, ospC1, yccE, and yfdF in Shigella flexneri. Msphere. 2022; 7: e00485-22. PMID: 36346241

Weddle EA, Köseoğlu VK, DeVasure BA, Agaisse HF. The type three secretion system effector protein IpgB1 promotes Shigella flexneri cell-to-cell spread through double-membrane vacuole escape. PLoS Pathogens. 2022;18: e1010380. PMID: 35202448

Köseoğlu VK, Jones MK, Agaisse H. The type 3 secretion effector IpgD promotes S. flexneri dissemination. PLoS Pathogens. 2022;18:e1010324. PMID: 35130324

Shankman LS, Fleury ST, Evans WB, Penberthy KK, Arandjelovic S, Blumberg RS, Agaisse H, Ravichandran KS. Efferocytosis by Paneth cells within the intestine. Current Biology. 2021; 31: 2469-76. PMID: 33852873 

Leslie JL, Weddle E, Yum LK, Lin Y, Jenior ML, Lee B, Ma JZ, Kirkpatrick BD, Nayak U, Platts-Mills JA, Agaisse HF. Lewis blood-group antigens are associated with altered susceptibility to shigellosis. Clinical Infectious Diseases. 2021; 72: e868-71. PMID: 32940644

Yum LK, Agaisse H. Mechanisms of bacillary dysentery: lessons learnt from infant rabbits. Gut Microbes. 2019; 1-6. PMID: 31570038

Köseoğlu VK, Agaisse H. Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility. MBio. 2019; 10(4). PMID: 31455648

Michard C, Yum LK, Agaisse H. WIPF2 promotes Shigella flexneri actin-based motility and cell-to-cell spread. Cell Microbiol. 2019; e13098. PMID: 31414511

Yum LK, Byndloss MX, Feldman SH, Agaisse H. Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery. Nat Commun. 2019; 10(1):1826. PMID: 31015451

Köseoğlu VK, Hall CP, Rodríguez-López EM, Agaisse H. The Autotransporter IcsA Promotes Shigella flexneri Biofilm Formation in the Presence of Bile Salts. Infect Immun. 2019; 87(7). PMID: 30988059

Q S Medeiros PH, Ledwaba SE, Bolick DT, Giallourou N, Yum LK, Costa DVS, Oriá RB, Barry EM, Swann JR, Lima AÂM, Agaisse H, Guerrant RL.A murine model of diarrhea, growth impairment and metabolic disturbances with Shigella flexneri infection and the role of zinc deficiency. Gut Microbes. 2019;10(5):615-630. PMID: 30712505

Weddle E, Agaisse H. Principles of intracellular bacterial pathogen spread from cell to cell. PLoS Pathog. 2018; 14(12):e1007380. PMID: 30543716

Weddle E, Agaisse H. Spatial, Temporal, and Functional Assessment of LC3-Dependent Autophagy in Shigella flexneri Dissemination. Infect Immun. 2018; 86(8). PMID: 29844234

Anderson CJ, Satkovich J, Köseoğlu VK, Agaisse H, Kendall MM. The Ethanolamine Permease EutH Promotes Vacuole Adaptation of Salmonella enterica and Listeria monocytogenes during Macrophage Infection. Infect Immun. 2018; 86(5). PMID: 29531136

Rossi RM, Yum L, Agaisse H, Payne SM. Cardiolipin Synthesis and Outer Membrane Localization Are Required for Shigella flexneri Virulence. MBio. 2017; 8(4). PMID: 28851846

Alvarez DE, Agaisse H, The Metalloprotease Mpl Supports Listeria monocytogenes Dissemination through Resolution of Membrane Protrusions into Vacuoles. 2016; Infection and Immunity. 84(6) 1806-14. PMID: 27068088

Agaisse H, Molecular and Cellular Mechanisms of Shigella flexneri Dissemination. 2016; Frontiers in Cellular and Infection Microbiology. 6:29. PMID: 27014639 | PMCID: PMC4786538

Borinskaya S, Velle KB, Campellone KG, Talman A, Alvarez D, Agaisse H, Wu YI, Loew LM, Mayer BJ, Integration of linear and dendritic actin nucleation in Nck-induced actin comets. 2015; Mol Biol Cell. 27(2) 247-59. PMID: 26609071 | PMCID: PMC4713129

Agaisse H, Shigella flexneri serotype 3a: the rise of a superbug.  2015; The Lancet. Infectious diseases. 15(8) 867-8. PMID: 25936610

Kuehl CJ, Dragoi AM, Talman A, Agaisse H, Bacterial spread from cell to cell: beyond actin-based motility. 2015; Trends in Microbiology. 23(9) 558-66. PMID: 26021574 | PMCID: PMC4560970

Dragoi AM, Agaisse H, The Class II Phosphatidylinositol 3-Phosphate Kinase PIK3C2A Promotes Shigella flexneri Dissemination through Formation of Vacuole-Like Protrusions. 2015; Infection and Immunity. 83(4) 1695-704. PMID: 25667265

Dragoi AM, Agaisse H, The serine/threonine kinase STK11 promotes Shigella flexneri dissemination through establishment of cell-cell contacts competent for tyrosine kinase signaling. 2014; Infection and Immunity. 82(11) 4447-57. PMID: 25114112 | PMCID: PMC4249316

Kuehl CJ, Dragoi AM, Agaisse H, The Shigella flexneri type 3 secretion system is required for tyrosine kinase-dependent protrusion resolution, and vacuole escape during bacterial dissemination. 2014; PloS One. 9(11) e112738. PMID: 25405985 | PMCID: PMC4236203

Dragoi AM, Swiss R, Gao B, Agaisse H, Novel strategies to enforce an epithelial phenotype in mesenchymal cells. 2014; Cancer Research. 74(14) 3659-72. PMID: 24845104 | PMCID: PMC4102654

Alvarez DE, Agaisse H, The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility. 2013; The Journal of Cell Biology. 202(7) 1075-90. PMID: 24062339 | PMCID: PMC3787377

Talman AM, Chong R, Chia J, Svitkina T, Agaisse H, Actin network disassembly powers dissemination of Listeria monocytogenes. 2013; Journal of Cell Science. 127(0) 240-9. PMID: 24155331 | PMCID: PMC3874788

McDonough JA, Newton HJ, Klum S, Swiss R, Agaisse H, Roy CR, Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening. 2013; mBio. 4(1) e00606-12. PMID: 23362322 | PMCID: PMC3560531

Alvarez DE, Agaisse H, Casein kinase 2 regulates vaccinia virus actin tail formation. 2012; Virology. 423(2) 143-51. PMID: 22209233

Dragoi AM, Talman AM, Agaisse H, Bruton’s tyrosine kinase regulates Shigella flexneri dissemination in HT-29 intestinal cells. 2012; Infection and Immunity. 81(2) 598-607. PMID: 23230296 | PMCID: PMC3553807

Chong R, Squires R, Swiss R, Agaisse H, RNAi screen reveals host cell kinases specifically involved in Listeria monocytogenes spread from cell to cell.,2011; PloS One. 6(8) e23399. PMID: 21853127 | PMCID: PMC3154492

Chong R, Swiss R, Briones G, Stone KL, Gulcicek EE, Agaisse H, Regulatory mimicry in Listeria monocytogenes actin-based motility. 2009; Cell Host & Microbe. 6(3) 268-78. PMID: 19748468 | PMCID: PMC2752869

Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E, RNA interference screen for human genes associated with West Nile virus infection. 2008; Nature. 455(7210) 242-5. PMID: 18690214 | PMCID: PMC3136529

Derré I, Pypaert M, Dautry-Varsat A, Agaisse H, RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection. 2007; PLoS Pathogens. 3(10) 1446-58. PMID: 17967059 | PMCID: PMC2042019

Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE, Genome-wide RNAi screen for host factors required for intracellular bacterial infection. 2005; Science. 309(5738) 1248-51. PMID: 16020693