Dr. Gang Xiang

Office Location: Pinn Hall, Room 4219

Email: fdb9ht@virginia.edu

My research background primarily focuses on fermentation and enzyme engineering. I have expertise in various areas, including recombinant protein expression, purification, and enzymatic activity analysis. Additionally, I have experience in the biochemical characterization of carbohydrate-active enzymes and analyzing products derived from enzyme-catalyzed reactions. Currently, my research interests revolve around the development of genetically encoded biosensors and their applications.

Current position:

Research associate, Chemical Biology, 07/2024-Present

Previous Education and Professional Experiences:

Post-doc, Identification of glycoforms of antibody with a single-molecule nanopore
07/2022-12/2022 Fudan University, Shanghai, China

Ph.D and post-doc, Enzyme engineering and enzyme catalysis, 09/2016-03/2022
Bioproduct Engineering, University of Groningen, Groningen, The Netherlands
Advisor: M.J.E.C. van der Maarel
Thesis titled “Dual biological role of glycoside hydrolase family fifty-seven glycogen branching enzymes”

M.sc. Fermentation engineering, East China University of Science and Technology, Shanghai, China, 09/2010-07/2013

Publications:

1. Gang Xiang, Hans Leemhuis, Marc J.E.C. van der Maarel. Structural elements determining the transglycosylating activity of glycoside hydrolase family 57 glycogen branching enzymes. Proteins: structure, function, and bioinformatics. 2022; 90:155-163.

2. Gang Xiang, Piet L. Buwalda, Marc J.E.C. van der Maarel, Hans Leemhuis. The thermostable 4,6-α-glucanotransferase of Bacillus coagulans DSM 1 synthesizes isomaltooligosaccharides. Amylase. 2021; 5:13-22.

3. Aline L.O. Gaenssle, Caecilia A. Satyawan, Gang Xiang, Marc J.E.C. van der Maarel, Edita Jurak. Long chains and crystallinity govern the enzymatic degradability of gelatinized starches from conventional and new sources. Carbohydrate polymers. 2021; 260: article 117801.

4. Gang Xiang, Jiang Li, Jifu Duan, Fei Shao, Jiajie Xu, Shuilin Fu, Heng Gong. Acceleration effect of amino acid supplementation on glycerol assimilation by Escherichia coli in minimal medium. Biotechnology letters. 2013; 35:1495-1500.