The Biomolecular Analysis Facility  provides a range of services for analyzing peptides and proteins using instruments and expertise not available to individual laboratories in the former Biomedical Mass Spectrometry Laboratory. The former Shared Instrumention Core is now part of the Biomolecular Analysis Facility and provides a range of user operated instruments and chromatography services. The former DNA Sciences core is now the Genome Analysis and Technology Core.

The Facility is located in rooms 1034, 1105, 1074 on the first floor of Pinn (formerly Jordan) Hall,  phone 434-924-0070

The Facility operates on a fee for service basis, detailed in the section on rates. The Cancer Center may provide a copayment to reduce the cost of services to its members. Rates for outside clients are higher. In addition to user fees, the Facility is supported by School of Medicine and receives grants for instrumentation from the state Equipment Trust Fund and NIH, and the School of Medicine. The mass spectrometry laboratory was started and supported for several years by a grant from the W.M. Keck Foundation.

News

The Biomolecular Analysis Facility Core has been awarded funding from the Virginia Equipment Trust Fund ($911,000) to purchase a new mass spectrometer. The instrument is a Q Exactive HF-X with high and low flow UHPLCs as well as CE for the interfaces. Experiments in proteomics and metabolomics can be performed and intact protein work will now be possible.  More details and seminars will follow this Summer and Fall. The instrument will replace the older Velos Pro Orbitrap and TSQ Quantum.  Services run on the MALDI-TOF instrument are not effected.

The instrument is now is use and running samples. As expected, performance is an improvement over the previous instrument.

Users should acknowledge the support from the School of Medicine e.g.

“This work used (service and/or instrument name) in the Biomolecular Analysis Facility which is supported by the University of Virginia School of Medicine.”

A resource statement summarizes the capabilities of the core.