The brain is a genetic mosaic with neuron-to-neuron genomic differences. Altered levels of mosaicism have been associated with neurodegenerative (e.g., Ataxia-telangiectasia) and neuropsychiatric disorders (e.g., schizophrenia and Rett’s syndrome). A deeper understanding of these and other neurological disorders is expected from ever-increasing understanding and measurement of neuronal genomic diversity.
Brain tumor clinical trials, brain tumor epidemiology
Erin Foff, Assistant Professor of Neurology