Michael Ayers, MD

Assistant Professor of Medicine
Cardiovascular Division

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RESEARCH SUMMARY

Dr. Ayers’s research focuses predominantly on hypertrophic cardiomyopathy (HCM). Sr. Ayers focused on studies examining the relationship between morphology, hemodynamic impairment, flow, and metabolism in HCM to develop and further our understanding of novel therapies for reducing symptoms, remodeling, and fibrosis. Dr. Ayers is the primary investigator on an ongoing prospective study examining changes in myocardial blood flow as measured by cardiac PET in HCM patients on mavacamten, a cardiac myosin inhibitor. Using real-world data, Dr. Ayers is interested in how tertiary referral centers impact accuracy and time to diagnosis and referral patterns. Dr. Ayers a site PI and co-PI on multiple ongoing prospective, randomized studies in HCM.

Dr. Ayers completed a fellowship in medical education, and we are currently studying how AI instruments like Chat-GPT contribute to (or detract from) medical student learning.

Dr. Ayers also has research interests in sports cardiology, echocardiography, nuclear cardiology, and prevention and lipid metabolism.

High Impact Research Publications

Moroni F, Ayers MP, Dixon DL, Abbate A. Proprotein Convertase Subtilisin Kexin-9 Inhibitors (PCSK9i) in Atherosclerotic Cardiovascular Disease: Real-World Data Welcome. J Cardiovasc Pharmacol. 2023 May 1;81(5):336-338. doi: 10.1097/FJC.0000000000001411. PMID: 37043382.
Ayers MP, Kramer CM. Imaging Myofibrillar Disarray and Microvascular Dysfunction in Hypertrophic Cardiomyopathy: Novel Imaging Biomarkers for a New Era in Therapeutics. Circulation. 2023 Sep 5;148(10):819-821. doi: 10.1161/CIRCULATIONAHA.123.065789. Epub 2023 Sep 5. PMID: 37669360; PMCID: PMC10491427.
Ayers MP, Peruri AV, Bourque JM. Transforming ATTR cardiac amyloidosis into a chronic disease: The enormous potential of quantitative SPECT to improve diagnosis, prognosis, and monitoring of disease progression. J Nucl Cardiol. 2021 Oct;28(5):1846-1850. doi: 10.1007/s12350-021-02587-w. Epub 2021 Apr 13. PMID: 33851351.