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Center for Neuromodulation Research

Advancing Treatment and Technology

The University of Virginia’s Center for Neuromodulation Research (CNR) is the site of cutting-edge research on addiction and other psychiatric disorders. The CNR was established in August 2025 as part of the UVA Department of Psychiatry and Neurobehavioral Sciences.

We study how neuromodulation can be combined with medications and behavioral therapies to improve treatment outcomes for addiction and other psychiatric disorders. Alongside clinical outcomes, we use neuroimaging to understand why these treatments work—identifying the brain circuits they engage and how those changes translate into meaningful improvements in patients’ lives.

What is Neuromodulation? Learn About the Types of Neuromodulation We Study »

Neuromodulation is the targeted alteration of brain activity, achieved by delivering energy—such as sound waves or electrical impulses—to specific brain circuits. Medications also change how the brain functions, but they act throughout the body and reach the brain broadly. Neuromodulation can be directed at specific regions and circuits, allowing more precise control over where and when the effect occurs.

At the UVA Center for Neuromodulation Research, we study how different neuromodulation approaches can be used to treat psychiatric disorders. Our research focuses on modulating specific brain regions involved in reward, craving, and decision-making—areas that are often dysregulated in people with substance use and psychiatric disorders.

CNR Mission

  • Investigating innovative, cutting-edge approaches to complement standard treatments for addiction and psychiatric disorders. 
  • Improving the lives of those impacted in Virginia and beyond with a multidisciplinary focus on research, education, and patient care. 
James Mahoney, MD, UVA School of Medicine

James Mahoney, PhD, Center Director

Dr. James Mahoney is a clinical neuropsychologist with over 25 years of research experience investigating treatments for addiction and other psychiatric disorders.

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Curing with Sound: Focused Ultrasound

James Mahoney, PhD, discusses the use of focused ultrasound for addiction treatment in a podcast produced by the Focused Ultrasound Foundation.

Listen to the Podcast

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In the News

Dr. Daisy Thompson-Lake and Dr. James Mahoney discuss their cutting-edge research involving focused ultrasound for addiction and plans for future studies at UVA.

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