Jose Javier Provencio
Professor, Neurology
Bio & Overview
Academic Information
- Department
- Neurology
- Academic Title
- Associate Professor
Primary Education
- B.A., undefinedSwarthmore Collegenull
- M.D., undefinedPennsylvania State University College of Medicinenull
- Intern, undefinedMedical University of South Carolinanull
- Resident, Neurology, University of Virginianull
- Postdoc, Biology, University of Virginianull
- Resident, Internal Medicine, University of Virginianull
- Fellow, Medical Critical Care, University of Virginianull
- Fellow, Neurocritical Care, University of Virginianull
Other Appointments
- Secondary Appointment Associate Professor, Neuroscience
- Secondary Appointment Associate Professor, Neurosurgery
- Neuroimmunology
Other Affiliations
- BIMS
Research Interests
Research Disciplines
- Neuroimmunology
- Neuroscience
Research Opportunities
- Neuroimmunology
- Neuroscience
PhD Programs
- Neuroscience
Selected Publications
2025
Busl, KM, Bogossian, EG, Claassen, J, Helbok, R, Provencio, JJ, Robba, C, Vergouwen, MDI, Wolf, S, Zanier, E, Citerio, G. Beyond the bleed: navigating complications of aneurysmal subarachnoid hemorrhag- pathology, clinical implications, and management strategies. Critical Care (2025) 29:414. DOI: 10.1186/s13054-025-05640-z.
Limon, S, Coulibaly, AP, Provencio, JJ*. Small Molecule Myeloperoxidase (MPO) Inhibition Prevents Delayed Cerebral Injury (DCI) After Subarachnoid Hemorrhage (SAH) in a Murine Model. Neurocritical Care 2024 (Online ahead of print). DOI: 10.1007/s12028-024-02169-x. PMID: 39653978.
2024
Provencio JJ*, Inkelas S, Vergouwen MDI. Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: The Role of the Complement and Innate Immune System. Transl Stroke Res. 2024 Aug 21. doi: 10.1007/s12975-024-01290-5.Online ahead of print. PMID: 39168941.
Provencio, J. J. (2024). ICP Monitoring for Bacterial Meningitis: Is This Just One of the Blind Spots in Neurocritical Care?. NEUROCRITICAL CARE, 40(2), 448-476. doi:10.1007/s12028-024-01940-4
2023
Salken, I., Provencio, J. J., & Coulibaly, A. P. (2023). A potential therapeutic target: The role of neutrophils in the central nervous system. BRAIN BEHAVIOR & IMMUNITY-HEALTH, 33. doi:10.1016/j.bbih.2023.100688
Chang, C. W. J., Provencio, J. J., Pascual, J., Heavner, M. S. S., Olson, D., Livesay, S. L. L., & Kaplan, L. J. J. (2023). State-of-the-Art Evaluation of Acute Adult Disorders of Consciousness for the General Intensivist. CRITICAL CARE MEDICINE, 51(7), 948-963. doi:10.1097/CCM.0000000000005893
2022
Provencio, J. J. (2023). Neurocritical Care Research Collaborations for Curing Coma. CRITICAL CARE CLINICS, 39(1), 47-54. doi:10.1016/j.ccc.2022.08.001
Mainali, S., Aiyagari, V., Alexander, S., Bodien, Y., Boerwinkle, V., Boly, M., . . . Suarez, J. I. (2022). Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness (June, 10.1007/s12028-022-01505-3, 2022). NEUROCRITICAL CARE, 37(2), 608-609. doi:10.1007/s12028-022-01536-w
Olson, D. M., Hemphill, J. C., Provencio, J. J., Vespa, P., Mainali, S., Polizzotto, L., . . . Suarez, J. I. (2022). The Curing Coma Campaign and the Future of Coma Research. SEMINARS IN NEUROLOGY, 42(03), 393-402. doi:10.1055/a-1887-7104
Mainali, S., Aiyagari, V., Alexander, S., Bodien, Y., Boerwinkle, V., Boly, M., . . . Suarez, J. I. (2022). Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. NEUROCRITICAL CARE, 37(1), 326-350. doi:10.1007/s12028-022-01505-3
Meissen, H., Gong, M. N., Wong, A. -K. I., Zimmerman, J. J., Nadkarni, N., Kane-Gil, S. L., . . . Aslakson, R. A. (2022). The Future of Critical Care: Optimizing Technologies and a Learning Healthcare System to Potentiate a More Humanistic Approach to Critical Care. CRITICAL CARE EXPLORATIONS, 4(3). doi:10.1097/CCE.0000000000000659
2021
Snyder, M. H., Ironside, N., Kumar, J. S., Doan, K. T., Kellogg, R. T., Provencio, J. J., . . . Chen, C. -J. (2022). Antiplatelet therapy and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. JOURNAL OF NEUROSURGERY, 137(1), 95-107. doi:10.3171/2021.7.JNS211239
Coulibaly, A. P., Pezuk, P., Varghese, P., Gartman, W., Triebwasser, D., Kulas, J. A., . . . Provencio, J. J. (2021). Neutrophil Enzyme Myeloperoxidase Modulates Neuronal Response in a Model of Subarachnoid Hemorrhage by Venous Injury. STROKE, 52(10), 3374-3384. doi:10.1161/STROKEAHA.120.033513
Claassen, J., Akbari, Y., Alexander, S., Bader, M. K., Bell, K., Bleck, T. P., . . . Suarez, J. I. (2021). Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. NEUROCRITICAL CARE, 35(SUPPL 1), 4-23. doi:10.1007/s12028-021-01260-x
Chang, C. W. J., Provencio, J. J., & Shah, S. (2021). Neurological Critical Care: The Evolution of Cerebrovascular Critical Care. CRITICAL CARE MEDICINE, 49(6), 881-900. doi:10.1097/CCM.0000000000004933
Provencio, J. J., & Hemphill, J. C. (2021). Response to: Communication and Well-Being Considerations in Disorders of Consciousness. NEUROCRITICAL CARE, 34(2), 704-705. doi:10.1007/s12028-020-01174-0
2020
Simpkins, A. N., Busl, K. M., Amorim, E., Barnett-Tapia, C., Cervenka, M. C., Dhakar, M. B., . . . Maciel, C. B. (2020). Proceedings from the Neurotherapeutics Symposium on Neurological Emergencies: Shaping the Future of Neurocritical Care. NEUROCRITICAL CARE, 33(3), 636-645. doi:10.1007/s12028-020-01085-0
Albright-Trainer, B., Provencio, J. J., O'Connor, C. M., Goldstein, R., Kohan, L., Solorzano, G., . . . Naik, B. I. (2020). A Case Report of Peripheral Nerve Stimulation for Acute Neuropathic Pain in Guillain-Barre Syndrome. A & A PRACTICE, 14(11). doi:10.1213/XAA.0000000000001315
Ramani, C., Davis, E. M., Kim, J. S., Provencio, J. J., Enfield, K. B., & Kadl, A. (2021). Post-ICU COVID-19 Outcomes A Case Series. CHEST, 159(1), 215-218. doi:10.1016/j.chest.2020.08.2056
Provencio, J. J., Hemphill, J. C., Claassen, J., Edlow, B. L., Helbok, R., Vespa, P. M., . . . Olson, D. M. (2020). The Curing Coma Campaign: Framing Initial Scientific Challenges-Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting. NEUROCRITICAL CARE, 33(1), 1-12. doi:10.1007/s12028-020-01028-9
Coulibaly, A. P., & Provencio, J. J. (2020). Aneurysmal Subarachnoid Hemorrhage: an Overview of Inflammation-Induced Cellular Changes. NEUROTHERAPEUTICS, 17(2), 436-445. doi:10.1007/s13311-019-00829-x
Kaplan, L., Moheet, A. M., Livesay, S. L., Provencio, J. J., Suarez, J. I., Bader, M. K., . . . Chang, C. W. J. (2020). A Perspective from the Neurocritical Care Society and the Society of Critical Care Medicine: Team-Based Care for Neurological Critical Illness. NEUROCRITICAL CARE, 32(2), 369-372. doi:10.1007/s12028-020-00927-1
2019
Coulibaly, A. P., Gartman, W. T., Swank, V., Gomes, J. A., Ruozhuo, L., DeBacker, J., & Provencio, J. J. (2020). RAR-Related Orphan Receptor Gamma T (RoRγt)-Related Cytokines Play a Role in Neutrophil Infiltration of the Central Nervous System After Subarachnoid Hemorrhage. NEUROCRITICAL CARE, 33(1), 140-151. doi:10.1007/s12028-019-00871-9
Rao, C. P. V., Suarez, J. I., Martin, R. H., Bauza, C., Georgiadis, A., Calvillo, E., . . . Tuan, V. B. (2020). Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2. NEUROCRITICAL CARE, 32(1), 88-103. doi:10.1007/s12028-019-00835-z
Blackburn, S. L., Grande, A. W., Swisher, C. B., Hauck, E. F., Jagadeesan, B., & Provencio, J. J. (2019). Prospective Trial of Cerebrospinal Fluid Filtration After Aneurysmal Subarachnoid Hemorrhage via Lumbar Catheter (PILLAR). STROKE, 50(9), 2558-2561. doi:10.1161/STROKEAHA.119.025399
Hocker, S., Shah, S., Vespa, P., Provencio, J. J., Calvillo, E., Olson, D. M., . . . Suarez, J. I. (2020). The Future of Neurocritical Care Research: Proceedings and Recommendations from the Fifth Neurocritical Care Research Network Conference. NEUROCRITICAL CARE, 32(1), 311-316. doi:10.1007/s12028-019-00767-8
Coulibaly, A., Pezuk, P., Varghese, P., Gartman, W., Triebwasser, D., Kulas, J., . . . Provencio, J. (2019). The neutrophil enzyme myeloperoxidase directly modulates neuronal response after subarachnoid hemorrhage, a sterile injury model. doi:10.1101/627638
2018
Taylor, D. G., Chen, C. -J., Buell, T. J., Park, M. S., Provencio, J. J., & Kalani, M. Y. S. (2018). Pericyte-associated hemorrhage in arteriovenous malformations. JOURNAL OF NEUROSURGERY, 129(6), 1653-1654. doi:10.3171/2018.1.JNS1899
2017
Lapides, D. A., Abusamaan, M. S., Davick, J. J., Sharma, A. M., Mandell, J. W., Lopes, M. B. S., . . . Southerland, A. M. (2017). Segmental arterial mediolysis A rare cause of rapidly progressive arterial dissections. NEUROLOGY-CLINICAL PRACTICE, 7(6), E43-E46. doi:10.1212/CPJ.0000000000000403
Ksendzovsky, A., Pomeraniec, I. J., Zaghloul, K. A., Provencio, J. J., & Provencio, I. (2017). Clinical implications of the melanopsin-based non-image-forming visual system. NEUROLOGY, 88(13), 1282-1290. doi:10.1212/WNL.0000000000003761
2016
Ferreira Da Silva, I. R., Gomes, J. A., Wachsman, A., de Freitas, G. R., & Provencio, J. J. (2017). Hematologic counts as predictors of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. JOURNAL OF CRITICAL CARE, 37, 126-129. doi:10.1016/j.jcrc.2016.09.011
Frontera, J. A., Provencio, J. J., Sehba, F. A., McIntyre, T. M., Nowacki, A. S., Gordon, E., . . . Aledort, L. (2017). The Role of Platelet Activation and Inflammation in Early Brain Injury Following Subarachnoid Hemorrhage. NEUROCRITICAL CARE, 26(1), 48-57. doi:10.1007/s12028-016-0292-4
Provencio, J. J., Swank, V., Lu, H., Brunet, S., Baltan, S., Khapre, R. V., . . . Ransohoff, R. M. (2016). Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors. BRAIN BEHAVIOR AND IMMUNITY, 54, 233-242. doi:10.1016/j.bbi.2016.02.007
Kwon, H. -M., Lynn, M. J., Turan, T. N., Derdeyn, C. P., Fiorella, D., Lane, B. F., . . . Chimowitz, M. I. (2016). Frequency, Risk Factors, and Outcome of Coexistent Small Vessel Disease and Intracranial Arterial Stenosis Results From the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial. JAMA NEUROLOGY, 73(1), 36-42. doi:10.1001/jamaneurol.2015.3145
Elsharkawy, H., Abd-Elsayed, A., El-Hadi, S., Provencio, J., & Tetzlaff, J. (2016). Fluctuating Electrocardiographic Changes Predict Poor Outcomes After Acute Subarachnoid Hemorrhage. OCHSNER JOURNAL, 16(3), 225-229. Retrieved from https://www.webofscience.com/
Da Silva, I. R., Gomes, J. A., Wachsman, A., de Freitas, G. R., & Provencio, J. J. (2016). Effect of Age on Transcranial Doppler Velocities in Patients with Aneurysmal Subarachnoid Hemorrhage. EUROPEAN NEUROLOGY, 76(5-6), 261-266. doi:10.1159/000452273
2015
Tisherman, S., Bullock, M. R., Provencio, J., & Rincon, F. (2015). Intraoperative Temperature Management. THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT, 5(2), 68-72. doi:10.1089/ther.2015.1505
2014
Le Roux, P., Menon, D. K., Citerio, G., Vespa, P., Bader, M. K., Brophy, G., . . . Taccone, F. (2014). The International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care: Evidentiary Tables A Statement for Healthcare Professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. NEUROCRITICAL CARE, 21, 297-361. doi:10.1007/s12028-014-0081-x
Le Roux, P., Menon, D. K., Citerio, G., Vespa, P., Bader, M. K., Brophy, G., . . . Taccone, F. (2014). The International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care: A List of Recommendations and Additional Conclusions A Statement for Healthcare Professionals From the Neurocritical Care Society and the European Society of Intensive Care Medicine. NEUROCRITICAL CARE, 21, 282-296. doi:10.1007/s12028-014-0077-6
Provencio, J. J., & Badjatia, N. (2014). Monitoring Inflammation (Including Fever) in Acute Brain Injury. NEUROCRITICAL CARE, 21, 177-186. doi:10.1007/s12028-014-0038-0
Figaji, A., & Puppo, C. (2014). Multimodality Monitoring Consensus Statement: Monitoring in Emerging Economies. NEUROCRITICAL CARE, 21, 239-269. doi:10.1007/s12028-014-0019-3
McNett, M. M., & Horowitz, D. A. (2014). International Multidisciplinary Consensus Conference on Multimodality Monitoring: ICU Processes of Care. NEUROCRITICAL CARE, 21, 215-228. doi:10.1007/s12028-014-0020-x
Miller, C., & Armonda, R. (2014). Monitoring of Cerebral Blood Flow and Ischemia in the Critically Ill. NEUROCRITICAL CARE, 21, 121-128. doi:10.1007/s12028-014-0021-9
Claassen, J., & Vespa, P. (2014). Electrophysiologic Monitoring in Acute Brain Injury. NEUROCRITICAL CARE, 21, 129-147. doi:10.1007/s12028-014-0022-8
Naidech, A. M., & Kumar, M. A. (2014). Monitoring of Hematological and Hemostatic Parameters in Neurocritical Care Patients. NEUROCRITICAL CARE, 21, 168-176. doi:10.1007/s12028-014-0023-7
Riker, R. R., & Fugate, J. E. (2014). Clinical Monitoring Scales in Acute Brain Injury: Assessment of Coma, Pain, Agitation, and Delirium. NEUROCRITICAL CARE, 21, 27-37. doi:10.1007/s12028-014-0025-5
Hutchinson, P., & O'Phelan, K. (2014). International Multidisciplinary Consensus Conference on Multimodality Monitoring: Cerebral Metabolism. NEUROCRITICAL CARE, 21, 148-158. doi:10.1007/s12028-014-0035-3
Oddo, M., & Bosel, J. (2014). Monitoring of Brain and Systemic Oxygenation in Neurocritical Care Patients. NEUROCRITICAL CARE, 21, 103-120. doi:10.1007/s12028-014-0024-6
Badjatia, N., & Vespa, P. (2014). Monitoring Nutrition and Glucose in Acute Brain Injury. NEUROCRITICAL CARE, 21, 159-167. doi:10.1007/s12028-014-0036-2
Taccone, F. S., & Citerio, G. (2014). Advanced Monitoring of Systemic Hemodynamics in Critically Ill Patients with Acute Brain Injury. NEUROCRITICAL CARE, 21, 38-63. doi:10.1007/s12028-014-0033-5
Chou, S. H. -Y., & Robertson, C. S. (2014). Monitoring Biomarkers of Cellular Injury and Death in Acute Brain Injury. NEUROCRITICAL CARE, 21, 187-214. doi:10.1007/s12028-014-0039-z
Helbok, R., Olson, D. M., Le Roux, P. D., & Vespa, P. (2014). Intracranial Pressure and Cerebral Perfusion Pressure Monitoring in Non-TBI Patients: Special Considerations. NEUROCRITICAL CARE, 21, 85-94. doi:10.1007/s12028-014-0040-6
Vespa, P., Menon, D., & Le Roux, P. (2014). The International Multi-disciplinary Consensus Conference on Multimodality Monitoring: Future Directions and Emerging Technologies. NEUROCRITICAL CARE, 21, 270-281. doi:10.1007/s12028-014-0049-x
Czosnyka, M., & Miller, C. (2014). Monitoring of Cerebral Autoregulation. NEUROCRITICAL CARE, 21, 95-102. doi:10.1007/s12028-014-0046-0
Schmidt, J. M., & De Georgia, M. (2014). Multimodality Monitoring: Informatics, Integration Data Display and Analysis. NEUROCRITICAL CARE, 21, 229-238. doi:10.1007/s12028-014-0037-1
Chesnut, R., Videtta, W., Vespa, P., & Le Roux, P. (2014). Intracranial Pressure Monitoring: Fundamental Considerations and Rationale for Monitoring. NEUROCRITICAL CARE, 21, 64-84. doi:10.1007/s12028-014-0048-y
Le Roux, P., Menon, D. K., Citerio, G., Vespa, P., Bader, M. K., Brophy, G. M., . . . Taccone, F. (2014). Consensus Summary Statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care A statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. NEUROCRITICAL CARE, 21, 1-26. doi:10.1007/s12028-014-0041-5
Le Roux, P., Menon, D. K., Citerio, G., Vespa, P., Bader, M. K., Brophy, G. M., . . . Taccone, F. (2014). Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care. INTENSIVE CARE MEDICINE, 40(9), 1189-1209. doi:10.1007/s00134-014-3369-6
Brogan, M. E., & Provencio, J. J. (2014). Spectrum of catastrophic brain injury: Coma and related disorders of consciousness. JOURNAL OF CRITICAL CARE, 29(4), 679-682. doi:10.1016/j.jcrc.2014.04.014
Gomes, J. A., Selim, M., Cotleur, A., Hussain, M. S., Toth, G., Koffman, L., . . . Provencio, J. J. (2014). Brain Iron Metabolism and Brain Injury Following Subarachnoid Hemorrhage: iCeFISH-Pilot (CSF Iron in SAH). NEUROCRITICAL CARE, 21(2), 285-293. doi:10.1007/s12028-014-9977-8
Alexander, S. A., & Provencio, J. J. (2014). Haptoglobin genotype Response. JOURNAL OF NEUROSURGERY, 120(2), 384-385. Retrieved from https://www.webofscience.com/
2013
Kantor, E., Bayir, H., Ren, D., Provencio, J. J., Watkins, L., Crago, E., . . . Alexander, S. A. (2014). Haptoglobin genotype and functional outcome after aneurysmal subarachnoid hemorrhage. JOURNAL OF NEUROSURGERY, 120(2), 386-390. doi:10.3171/2013.10.JNS13219
Derdeyn, C. P., Chimowitz, M. I., Lynn, M. J., Fiorella, D., Turan, T. N., Janis, L. S., . . . Cloft, H. J. (2014). Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial. LANCET, 383(9914), 333-341. doi:10.1016/S0140-6736(13)62038-3
Provencio, J. J., Da Silva, I. R. F., & Manno, E. M. (2013). Intracerebral Hemorrhage: New Challenges and Steps Forward. NEUROSURGERY CLINICS OF NORTH AMERICA, 24(3), 349-+. doi:10.1016/j.nec.2013.03.002
da Silva, I. R. F., & Provencio, J. J. (2015). Intracerebral Hemorrhage in Patients Receiving Oral Anticoagulation Therapy. JOURNAL OF INTENSIVE CARE MEDICINE, 30(2), 63-78. doi:10.1177/0885066613488732
2012
Provencio, J. J. (2013). Inflammation in Subarachnoid Hemorrhage and Delayed Deterioration Associated with Vasospasm: A Review. CEREBRAL VASOSPASM: NEUROVASCULAR EVENTS AFTER SUBARACHNOID HEMORRHAGE, 115, 233-238. doi:10.1007/978-3-7091-1192-5_42
Smithason, S., Moore, S. K., & Provencio, J. J. (2013). Low-Dose Lipopolysaccharide Injection Prior to Subarachnoid Hemorrhage Modulates Delayed Deterioration Associated with Vasospasm in Subarachnoid Hemorrhage. CEREBRAL VASOSPASM: NEUROVASCULAR EVENTS AFTER SUBARACHNOID HEMORRHAGE, 115, 253-+. doi:10.1007/978-3-7091-1192-5_45
2011
Smithason, S., Moore, S. K., & Provencio, J. J. (2012). Systemic Administration of LPS Worsens Delayed Deterioration Associated with Vasospasm After Subarachnoid Hemorrhage Through a Myeloid Cell-Dependent Mechanism. NEUROCRITICAL CARE, 16(2), 327-334. doi:10.1007/s12028-011-9651-3
Spiotta, A. M., Provencio, J. J., Rasmussen, P. A., & Manno, E. (2011). Brain Monitoring After Subarachnoid Hemorrhage: Lessons Learned. NEUROSURGERY, 69(4), 755-766. doi:10.1227/NEU.0b013e31821d2b61
Chimowitz, M. I., Lynn, M. J., Derdeyn, C. P., Turan, T. N., Fiorella, D., Lane, B. F., . . . Cloft, H. J. (2011). Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis. NEW ENGLAND JOURNAL OF MEDICINE, 365(11), 993-1003. doi:10.1056/NEJMoa1105335
Chimowitz, M. I., Lynn, M. J., Turan, T. N., Fiorella, D., Lane, B. F., Janis, S., & Derdeyn, C. P. (2011). Design of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 20(4), 357-368. doi:10.1016/j.jstrokecerebrovasdis.2011.05.001
2010
Provencio, J. J., Altay, T., Smithason, S., Moore, S. K., & Ransohoff, R. M. (2011). Depletion of Ly6G/C+ cells ameliorates delayed cerebral vasospasm in subarachnoid hemorrhage. JOURNAL OF NEUROIMMUNOLOGY, 232(1-2), 94-100. doi:10.1016/j.jneuroim.2010.10.016