6/17/2025
Membrane proteins facilitate the transfer of information across lipid bilayers, comprise approximately 25% of a typical proteome, and represent over half of all drug targets. The membrane proteins that mediate…
6/17/2025
Background and Summary of Previous Findings: Neural development involves competition at many levels, whether it be axons innervating a target or synapses refining a connection. Over 50 years ago, Viktor…
6/17/2025
*Our perspective*: It is generally known that electrical signals lie at the very core of our beating hearts and thinking brains. It may however surprise you to know that the…
6/17/2025
Research in the DeSimone laboratory centers on the problem of morphogenesis, which is the process biological systems use to generate form and develop increasingly complex structures needed to carry out…
6/17/2025
The work of my laboratory over the last 40 years has been broadly concerned with the recognition of antigens by CD8 T cells. In the last 20 years, that work…
6/17/2025
OVERVIEW: How does the body recognize an infectious organism? During infection, how does it determine when to escalate inflammation for pathogen clearance versus dampen inflammation to prevent damage to self? What…
6/17/2025
Our research focuses on the application of chemical engineering principles to problems in microbial ecology. The aim is to develop a fundamental understanding of mechanisms underlying microbial behavior which will…
6/17/2025
Our research program is concerned with the synthesis, properties and applications of metal complexes with polymeric ligands. These multifunctional targets are prepared by combining coordination chemistry with living polymerization methodologies.…
6/17/2025
We develop nanoscale imaging methods for 3D single-molecule localization in intact bacterial cells. Our two primary research objectives are: 1. Development of 3D super-resolution imaging methods, including instrument design, sample preparation,…
6/17/2025
One major focus of our work is to study the cellular and molecular consequences of the blood supply in the eye. Specifically, we are interested in quantifying the biomechanical changes…
