6/17/2025
6/17/2025
The major focus of my lab is to understand how the genetic drivers of cancer fuel tumor evolution and to mechanistically define how these genes contribute to various tumor phenotypes.…
6/17/2025
Current work in the lab is focused on developing gene therapies for pharmacoresistant epilepsies and insulin replacement. In these projects we are leveraging our experience in molecular cloning to develop…
6/17/2025
All eukaryotic cells divide by assembling a microtubule-based spindle machinery that equally segregates chromosomes between daughter cells. The faithful segregation of chromosomes during cell division is essential as errors in…
6/17/2025
Cell signaling networks coordinate a wide variety of cellular physiology and gene regulatory programs. Perturbations in these signaling networks contribute to the pathogenesis of many diseases, including cardiovascular disease, cancer…
6/17/2025
Understanding how gene expression is regulated in response to signals from both inside and outside the body plays a critical role in allowing us to adapt to changes in the…
6/17/2025
The post-genomic era is marked by the development of technologies which have revealed the astonishing molecular diversity of gene products. Multiple distinct protein forms, or “proteoforms”, can arise through several…
6/17/2025
The Sonkusare laboratory studies the role of ion channels and calcium signaling mechanisms in regulating vascular function and blood pressure. Constriction of small arteries is a crucial determinant of blood…
6/17/2025
In eukaryotes, approximately 30% of all newly synthesized proteins pass through the endoplasmic reticulum (ER), where they undergo folding and maturation. A significant fraction of nascent proteins may fail to…
6/17/2025