6/17/2025
All the way up to the 20th century, the human genome has been optimized to survive in environments characterized by fluctuations between periods of feast and famine. These survivor-genomes clash…
6/17/2025
Systems analysis has become a requirement for making sense of high-throughput data and for characterizing properties of biological networks. In order to extend these recent developments to medical applications, there…
6/17/2025
Much of our work focuses on cell signaling and mechanisms of lineage specification, differentiation and morphogenesis. Particular emphases have been on post-embryonic neural crest stem cells and their derivatives, including…
6/17/2025
How do the regulatory networks that maintain gene expression programs change in response to stimuli and in disease states? The primary goal of my research program is to address this…
6/17/2025
1. Detection of genomic variation: I have developed several methods to identify and map variants (SNPs, indels, and large-scale rearrangements) from large-scale sequencing datasets. This includes identification and genotyping of…
6/17/2025
Our research on viruses provides insight not only into the diseases they cause, but it also leads to the discovery of novel basic mechanisms that operate in eukaryotic cells. Over…
6/17/2025
Dr. Rich's research is centered on understanding the genetic epidemiology of complex human disease, including the genes contributing to atherosclerosis, stroke and intermediate phenotypes (risk factors). These studies range from…
6/17/2025
My research is at the interface of computation and biology, drawing on techniques in computer science, data science, bioinformatics, and statistics, and applying them to biological questions in cancer, epigenetics,…
6/17/2025
The post-genomic era is marked by the development of technologies which have revealed the astonishing molecular diversity of gene products. Multiple distinct protein forms, or “proteoforms”, can arise through several…
6/17/2025
Agnieszka Swiatecka-Urban studied the regulation of cell-surface stability and intracellular trafficking of membrane proteins in epithelial cells. One focus of her research activity has been the characterization of mechanisms and…
