6/17/2025
The work of my laboratory over the last 40 years has been broadly concerned with the recognition of antigens by CD8 T cells. In the last 20 years, that work…
6/17/2025
The general goal of my lab is to develop MRI techniques for assessing the structure, function, and perfusion of the cardiovascular system, particularly in the setting of heart disease. Recent…
6/17/2025
Structural biology of membrane proteins: Membrane proteins represent about ~25% of all proteins in any given genome carrying out many vital functions (transporters, receptors, channels, etc..). Membrane proteins also represent ~50%…
6/17/2025
They have no symptoms, but subjects with untreated hypertension and salt sensitivity will have major health challenges such as blindness, stroke, kidney failure, and heart attacks. These devastating (and costly)…
6/17/2025
Our interests focus on developing gene therapy for treating and preventing cardio-vascular disease. An interdisciplinary approach is used to integrate recent technical advances with gene therapy research. In particular, cutting-edge…
6/17/2025
One major focus of our work is to study the cellular and molecular consequences of the blood supply in the eye. Specifically, we are interested in quantifying the biomechanical changes…
6/17/2025
Renin-synthesizing cells are crucial in the regulation of blood pressure and fluid and electrolyte homeostasis. These cells have been considered as terminally differentiated because they synthesize a hormone, are few…
6/17/2025
The focus of my research is on the modulation of aldosterone production. Aldosterone is a steroid hormone produced in the outer-most layer of the adrenal gland, a zone termed the…
6/17/2025
Our goal is to understand the molecular mechanisms by which cells move, with particular emphasis on muscle contraction. We examine the mechanics of these processes at the level of individual…
6/17/2025
As Paleolithic hunter gatherers, the human diet was relatively low in fats and simple carbohydrates. Technological advances, beginning with the agricultural revolution 12,000 years ago and culminating with the mechanization…
