The Ubiquitin System and Human Cancer
Neurobiology of the autonomic nervous system and the homeostatic control of breathing
Basic and translational brain tumor research
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Molecular Biosensors; Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Molecular Mechanisms of Transcriptional Regulation
Matrix Biology and Engineering
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Pathways to enhance T cell function in tumors.
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
Molecular Mechanisms for Membrane Transport and Cell Signaling
Engineering biomaterials as cellular microenvironments
The Neurobiology of Energy Balance
Mouse Visual System, physiology, functional imaging, genetics, molecular, behavioral, and computational methods
Systems Genetics Approaches to Understand Cardiometabolic Traits
Herpes Simplex Virus Infection of Neurons
Biophysical Chemistry: Membrane protein structure, function, and dynamics
Epigenetic mechanisms involved in complex human disease
Adult-born neurons, perineuronal nets, and microglia in hippocampal plasticity and behavior in health and disease
Neuron-glia and glial-glial interactions
Cellular and molecular mechanisms of Neisserial pathogenesis
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Host/pathogen Interaction - Chlamydia Infection
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis
Tumor microenvironment and mechanisms of tumor neovascularization
Structure and Function of Macromolecular Complexes Using Electron Microscopy
Macrophage effector functions in inflammation and immunotherapy
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Cardiovascular Magnetic Resonance Imaging; Coronary Heart Disease; Myocardial Function; Myocardial Perfusion
Immune mechanisms of pathogenic antibody production in allergy and autoimmunity
Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics
Cancer systems biology, Single-cell quantitative biology, Computational modeling
Systems Genetics of Skeletal Development and Maintenance
Novel Therapies for Treating and Preventing Ischemic Heart Disease
RNA-protein interactions in antiviral immunity and autoimmune diseases.
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Signal transduction in cancer cells
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Circadian entrainment for the treatment of metabolic and neurodegenerative diseases
Immune regulation for HCV infection and chronic liver inflammation
Immune response to infectious disease in the CNS
Molecular mechanisms controlling insulin signaling and fat synthesis.
Morphogenesis of the Developing Wolffian/Epididymal duct
Understanding Cellular and Molecular Mechanisms Leading to Blood Vessel Formation
Diagnostic ultrasound - image processing, quantification Molecular imaging using ultrasound Catheter-based ultrasound Ultrasound-based drug/gene delivery Ultrasound image guided therapy
Translating our discoveries in the microcirculation to tangible benefits in patients.
Systems-biology approaches to cancer biology and virology.
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
Localisation of nascent proteins to sub-cellular compartments
Seizures, neuronal excitability and plasticity
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Targeted delivery of therapeutic and diagnostic imaging agents.
Cardiac magnetic resonance imaging, myocardial disease, atherosclerotic plaque imaging, peripheral arterial disease, hypertrophic cardiomyopathy
The role of glia in the development, maintenance and regeneration of the nervous system
Precision medicine, translational science, regeneration, organoids, high resolution imaging, computational modeling
RNA regulatory networks and RNA binding proteins during cardiovascular development and in cardiovascular disease
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation to identifying therapeutic targets.
Restoration of Homeostasis in Disease
Neuronal Vulnerability: A Study of Cellular Mechanism
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Composition, Biophysics and Physiology of Cellular Membranes
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Developing novel neuroprotection strategies to preserve vision in glaucoma
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Wnt/PCP signaling in inner ear development Mouse models for human deafness Wnt/PCP signaling in neural tube closure
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Chemical biology of sphingosine 1-phosphate
Behavioral Pharmacology, Sex Differences, Animal Models of Addiction
Structure and Function of the GI Tract in the Context of Childhood Nutrition, Growth, Immunity, and Host-microbe Interactions
Magnetic Resonance Imaging Rapid and 3 D Techniques; Hyperpolarized Gases
Molecular Mechanisms of Myotonic Muscular Dystrophy
Transcriptional Regulation by NFKB
Immune System Regulation of Cardiometabolic Disease
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific Reproducibility
Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers
Regulation and function of tyrosine phosphorylation in complex networks
Structure-Function of Active Transporters
Obesity and Aging
Immune mechanisms of acute kidney injury and fibrosis. Pulsed ultrasound in acute kidney injury
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Immune mechanisms of defense against COVID-19 and enteric (diarrheal) infections
Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis
Novel therapeutic approaches to brain cancers and to other neurologic diseases
Nuclear Transport, Signaling, and Cancer
Understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13) and temporal lobe epilepsy. My lab uses a number of experimental techniques including patch clamp electrophysiology and in vivo seizure monitor
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Developmental Genetics, Evolution and Regeneration
Mechanisms of tissue/organ homeostasis and tumorigeensis
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Objective and quantitative modeling of data from imaging and other types of sensors
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
Cardiovascular MRI, Cardiovascular CT, Echocardiography, Nuclear Cardiology, Diastolic Heart Failure, Myocardial Perfusion, Coronary Artery Disease
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Molecular and genetic determinants of atherosclerosis and cardiometabolic disorders.
Regulation of neural stem cell proliferation during development and adulthood
Endocrine hypertension, angiotensin receptors, renal paracrine hormones
Transcriptional Silencing and Aging in Yeast
Role of Glia in Neurological Illnesses and Cancer
Design and Application of Chemical Biology Tools for Studying Cellular Communication
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Viral immunology, T cells, Macrophages, Tissue repair
Role of endoplasmic reticulum-associated protein degradation in health and disease
B cell Analysis and Engineering
How Viruses, Particularly Papillomaviruses, Can Cause Cancer
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Clonal hematopoiesis: A new mechanism of cardiovascular disease
Genome instability in cancer and repeat expansion diseases
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.
Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
The immune response to common cold and allergens in health and disease.
Cardiovascular Development and Cerebrovascular Pathologies
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
Mechanisms of Huntington's Disease Pathogenesis
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease
Early detection, cancer prevention, and tumor microenvironment
Single Cell Analysis
Neuroscience and Anesthetic Neuroprotection