Professor of Anesthesiology, Anesthesiology
- BS, Applied Biology, University of Coventry
- PhD, Physiology, University of Coventry
- Postdoc, Electrophysiology, University of Virginia
- Postdoc, Electrophysiology, University of Cambridge, Cambridge, England
Biophysics, Molecular Pharmacology, Neuroscience, Translational Science
Understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13) and temporal lobe epilepsy. My lab uses a number of experimental techniques including patch clamp electrophysiology and in vivo seizure monitor
The Patel lab focuses on understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13). SCN8A EE is a severe genetic epilepsy syndrome caused by de novo mutations in the SCN8A gene, which codes for the voltage-gated sodium channel isoform Nav1.6. Our lab has two mouse models of patient-derived SCN8A mutations; N1768D (Scn8aD/+) which allows global heterozygous expression of the N1768D pathogenic Scn8a variant and a conditional mouse in which the expression of R1872W (Scn8aw/+) mutation is dependent on Cre recombinase. Using a variety of techniques including both in vivo and in vitro recordings to better understand the development and mechanisms of seizure initiation and seizure induced death (SUDEP) in these mice.