Sylvia Cechova, PhD
PRIMARY APPOINTMENT
Assistant Professor of Research
Contact:
UVA Division of Nephrology
PO Box 800133
Charlottesville, VA 22908
Telephone: 434-924-4371
Fax: 434-924-5848
Email: sc9d@virginia.edu
EDUCATION AND TRAINING
- 1985 M Sc Chemistry, Comenius University, Bratislava, Slovakia
- 1991 PhD Comenius University, Bratislava, Slovakia
- 1996-2002 Research Associate, University of Virginia, Department of Anesthesiology
- 2005-2009 Research Associate, University of Virginia, Department of Chemistry
RESEARCH AREAS
- Acute and Chronic kidney disease
Lab Images
-
Sylvia Cechova, PhD
-
Sylvia Cechova, PhD
RESEARCH SUMMARY
In the last ten years, my scientific work has been done in the field of nephrology and hypertension to study the effect of several genes, namely Gstm1, Myh9, and Collectrin, on the severity and progression of chronic kidney disease and hypertension, using various animal models of kidney disease. Recently an essential role of iron-mediated injury (ferroptosis) emerged in acute and chronic kidney injury research. Hepcidin is a circulating peptide that reduces ferroportin-mediated iron export and induces macrophage iron retention. Many signaling pathways can contribute to acute/chronic kidney disease and fibrosis. The focus of the current research is the contribution of the sphingolipid pathway to the prevention or attenuation of fibrosis following AKI Dr. Okusa Lab and the role of natural IgM upregulation in the recovery after AKI Dr. Lobo Lab.