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Pediatric Center of Excellence

Previous Publications

  • McLaughlin N, Yao X, Li Y, Saifudeen Z, and El-Dahr SS. Histone signature of metanephric mesenchyme cell lines. Epigenetics 8(9):970-8, 2013. PMCID:PMC3883774
  • Forbes MS, Thornhill BA, Galarreta CI, Minor JJ, Gordon KA, Chevalier RL. Chronic unilateral ureteral obstruction in the neonatal mouse delays maturation of both kidneys and leads to late formation of atubular glomeruli. Am J Physiol Renal Physiol 305:F1736-F1746, 2013 PMCID 3882445
  • Chevalier RL, Forbes MS, Galarreta CI, Thornhill BA. Responses of proximal tubular cells to injury in congenital renal disease: Fight or flight. Pediatr Nephrol 29:537-541, 2013 PMCID:PMC3925758
  • Li Y, Liu J, McLaughlin N, Bachvarov, D,Saifudeen Z and El-Dahr SS. Genome-wide Analysis of the p53 Gene Regulatory Network in the Developing Mouse Kidney. Physiol Genomics. 2013 Sep 3. PMCID: PMC3798767
  • El-Dahr SS, Hilliard S, Aboudehen K, Saifudeen Z. The MDM2-p53 pathway: multiple roles in kidney development. Pediatr Nephrol. 2013 Sep 28. PMCID: PMC3969418
  • Lin, EE, Sequeira-Lopez, MLS and Gomez, RA. RBP-J in Foxd1+ renal stromal progenitors is crucial for the proper development and assembly of the kidney vasculature and glomerular mesangial cells. Am J Physiol-Renal 2014 Jan;306(2):F249-58 PMCID:PMC3920017
  • McLaughlin N, Wang F, Saifudeen Z, and El-Dahr SS. In situ histone landscape of nephrogenesis. Epigenetics 9(2):222-35, 2014. PMCID:PMC3962532
  • Galarreta CI, Grantham JJ, Forbes MS, Maser RL, Wallace DP, Chevalier RL. Tubular obstruction leads to progressive proximal tubular injury and atubular glomeruli in polycystic kidney disease. Am J Pathol 2014 Jul;184(7):1957-66. PMCID: PMC4076474
  • Li Y, Liu J, Li W, Feng Y, Li M, El-Dahr S and Saifudeen Z. p53 Enables Metabolic Fitness and Self-Renewal of Nephron Progenitor Cells. Development 2015 Apr 1:142(7):1228-41. PMCID: PMC4378244
  • Sequeira Lopez MLS, Lin EE, Li M, Hu Y, Sigmund CD, Gomez RA. The earliest metanephric arteriolar progenitors and their role in kidney vascular development. Am J Physiol Regul Integr Comp Physiol. 2015;308(2):R138-49. PMCID: PMC429786
  • Chen S, Yao X, Li Y, Saifudeen Z, Bachvarov D, El-Dahr SS. Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 2015 Mar 15:142(6):1180-92. PMID: 257582272.
  • Belyea BC, Xu F, Sequeira-Lopez MLS, Gomez RA. Loss of Jagged1 in Renin Progenitors Leads to Focal Kidney Fibrosis. Physiol Rep. 2015 Nov; 3(11). PMCID: PMC4673620
  • Adli M, Parlak M, Li Y, El-Dahr SS. Epigenetic States of nephron progenitors and epithelial differentiation. J Cell Biochem. 2015 Jun:116(6):893-902. PMID: 255604333.
  • Chevalier RL. Congenital urinary tract obstruction: The long view. Adv Chronic Kidney Dis. 2015 Jul;22(4):312-9. PMCID: PMC4475271
  • Sergio M, Galarreta CI, Thornhill BA, Forbes MS, Chevalier RL. The fate of nephrons in congenital obstructive nephropathy: Adult recovery is limited by nephron number despite early release of obstruction. J Urol. 2015 Nov;194(5):1463-72. PMCID: PMC4615464 [Available on 2016-11-01]
  • Singh R, Kuscu C, Quinlan A, Qi Y, Adli M. Cas9-chromatin binding information enables more accurate CRISPR off-target prediction. Nucleic Acids Res. 2015 Oct 15;43(18):e118. PMCID: PMC4605288
  • Lu KT, Keen HL, Weatherford ET, Sequeira-Lopez ML, Gomez RA, Sigmund CD. Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression. Hypertension. 2016 May;67(5):992-9. PubMed PMID: 26928806; PubMed Central PMCID: PMC4833511.
  • Gomez RA, Sequeira-Lopez ML. Novel Functions of Renin Precursors in Homeostasis and Disease. Physiology (Bethesda). 2016 Jan;31(1):25-33. PubMed PMID: 26661526; PubMed Central PMCID: PMC4698453.
  • Hu Y, Li M, Göthert JR, Gomez RA, Sequeira-Lopez ML. Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development. J Am Soc Nephrol. 2016 Jul;27(7):1984-95. PubMed PMID: 26534925. (Epub ahead of print) [PMCID In Progress]
  • Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA. Vascular versus tubular renin: role in kidney development. Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R650-7. PubMed PMID: 26246508; PubMed Central PMCID: PMC4591368.
  • Lin EE, Pentz ES, Sequeira-Lopez ML, Gomez RA. Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling. Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R576-84. PubMed PMID: 26180185; PubMed Central PMCID: PMC4591380.
  • Sequeira-Lopez, MLS, Torban E. New insights into precursors of the renal endothelium. Kidney Int (In press) 2016. [PMCID in progress]
  • Liu, H, Chen S, Yao X, Li Y, Saifudeen Z, El-Dahr SS. Histone Deacetylases 1 and 2 balance nephron progenitor renewal and differentiation during kidney organogenesis. In preparation.
  • Hickmann L, Steglich A Gerlach M Al-Mekhlafi M, Sradnick J, LAchmann P, Sequeira-Lopez MLS, Gomez RA, Hohenstein B, Hugo C, Todorov VT. Persistent and inducible neogenesis repopulates progenitor renin lineage cells in the kidney. Kidney Int. 2017;92(6):1419-1432PMCID: PMC5696031
  • Song R, Sequeira-Lopez MLS, Yosypiv IV. Foxd1 is an upstream regulator of the renin-angiotensin system during metanephric kidney development. Pediatric Research 2017;82(5):855-862 PMCID: PMC5645264.
  • Oka M, Medrano S, Sequeira-Lopez MLS, Gomez RA. Chronic stimulation of renin cells leads to vascular pathology. Hypertension 2017; 70(1):119-128. Featured Editorial Commentary. PMCID: PMC5501939
  • Sequeira-Lopez MLS, Gomez RA. Preserving kidney health during intensive blood pressure control. Nat Rev Nephrol. 2018 Sep;14(9):537-538. doi: 10.1038/s41581-018-0034-2. PMID: 29899563; PMCID: PMC6369411.
  •  Neubauer B, Schrankl J, Steppan D, Neubauer K, Sequeira Lopez MLS, Pan L, Gomez RA, Coffman TM, Gross KW, Kurtz A, Wagner C. Angiotensin II Short-Loop Feedback: Is There a Role of Ang II for the Regulation of the Renin System In Vivo? Hypertension. 2018; 71(6):1075-1082. PMCID: PMC5945294
  • Gomez RA and Sequeira Lopez MLS. Renin Cells in homeostasis, regeneration and immune defence mechanisms. Nature Reviews Nephrology 2018;14(4):231-245. PMCID: PMC5854538
  • Vidya K. Nagalakshmi , Minghong Li , Soham Shah , Joseph C. Gigliotti , Alexander L. Klibanov , Frederick H. Epstein , Robert L. Chevalier , R. Ariel Gomez and Maria Luisa S. Sequeira-Lopez. Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction. Clinical Science (2018) 132 2519–2545. Featured cover. IF=5.62 Highlighted in ASN in the Loop and in Healio. PMCID: PMC6415776.
  • Martinez MF, Medrano S, Brown EA, Tufan T, Shang S, Bertoncello N, Guessoum O, Adli M, Belyea BC, Sequeira-Lopez MLS, Gomez RA. Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis. J Clin Invest. 2018 Nov 1;128(11):4787-4803. doi: 10.1172/JCI121361. Epub 2018 Oct 2. PMID: 30130256.
  • Belyea BC, Xu F, Sequeira-Lopez MLS, Gomez RA. Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin. Disease models & mechanisms. 2018 December 18;11(12). PubMed PMID: 30467111; PubMed Central PMCID: PMC6307899.
  • Tang J, Wysocki J, Ye M, Vallés PG, Rein J, Shirazi M, Bader M, Gomez RA, Sequeira-Lopez MS, Afkarian M, Batlle D. Urinary Renin in Patients and Mice With Diabetic Kidney Disease. Hypertension. 2019 May 13:HYPERTENSIONAHA11912873. doi: 10.1161/HYPERTENSIONAHA.119.12873. [Epub ahead of print] PubMed PMID: 31079532.
  • Yosypiv IV, Sequeira-Lopez MLS, Song R, De Goes Martini A. Stromal prorenin receptor is critical for normal kidney development. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R640-R650. doi: 10.1152/ajpregu.00320.2018. Epub 2019 Apr 3. PMID: 30943054; PMCID: PMC6734076.
  • Mohamed T, Sequeira-Lopez MLS. Development of the renal vasculature. Semin Cell Dev Biol. 2019 Jul;91:132-146. doi: 10.1016/j.semcdb.2018.06.001. Epub 2018 Jun 6. PMID: 29879472; PMCID: PMC6281798.
  • Schramm A, Schweda F, Sequeira-Lopez MLS, Hofmann F, Sandner P, Schlossmann J. Protein kinase G is involved in acute but not in long-term regulation of renin secretion. Front Pharmacol. 2019;10:800. doi: 10.3389/fphar.2019.00800. eCollection 2019. PMCID: PMC6657341
  • Mohamed TH, Watanabe H, Kaur R, Belyea BC, Walker PD, Gomez RA, Sequeira-Lopez MLS. Renin-Expressing Cells Require β1-Integrin for Survival and for Development and Maintenance of the Renal Vasculature. Hypertension. 2020 Aug;76(2):458-467. doi: 10.1161/HYPERTENSIONAHA.120.14959. Epub 2020 Jun 29. PMID: 32594804; PMCID: PMC7347440.
  • Oh J, Matkovich SJ, Riek AE, Bindom SM, Shao JS, Head RD, Barve RA, Sands MS, Carmeliet G, Osei-Owusu P, Knutsen RH, Zhang H, Blumer KJ, Nichols CG, Mecham RP, Baldán Á, Benitez BA, Sequeira-Lopez ML, Gomez RA, Bernal-Mizrachi C. Macrophage secretion of miR-106b-5p causes renin-dependent hypertension. Nat Commun. 2020 Sep 23;11(1):4798. doi: 10.1038/s41467-020-18538-x. PMID: 32968066; PMCID: PMC7511948.
  • Hoy J, Nishimura H, Mehalic T, Yaoita E, Gomez RA, Paxton R, Sequeira-Lopez MLS. Ontogeny of renin gene expression in the chicken, Gallus gallus. Gen Comp Endocrinol. 2020 Sep 15;296:113533. doi: 10.1016/j.ygcen.2020.113533. Epub 2020 Jun 17. PMID: 32561435; PMCID: PMC7678913.)
  • DeLalio LJ, Masati E, Mendu S, Ruddiman CA, Yang Y, Johnstone SR, Milstein JA, Keller TCS 4th, Weaver RB, Guagliardo NA, Best AK, Ravichandran KS, Bayliss DA, Sequeira-Lopez MLS, Sonkusare SN, Shu XH, Desai B, Barrett PQ, Le TH, Gomez RA, Isakson BE. Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis. Kidney Int. 2020 Sep;98(3):630-644. doi: 10.1016/j.kint.2020.04.041. Epub 2020 May 21. PMID: 32446934; PMCID: PMC7483468.
  • Belyea BC, Santiago AE, Vasconez WA, Nagalakshmi VK, Mehalic TC, Sequeira-Lopez MLS, Gomez RA. A primitive type of renin-expressing lymphocyte protects the organism against infections. bioRxiv. doi: https://doi.org/10.1101/770511(preprint)
  • Watanabe H, Paxton RL, Tolerico MR, Nagalakshmi VK, Tanaka S, Okusa MD, Goto S, Narita I, Watanabe S, Sequeira-Lοpez MLS, Gomez RA. Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells. Am J Physiol Renal Physiol. 2020 Oct 1;319(4):F603-F611. doi: 10.1152/ajprenal.00348.2020. Epub 2020 Aug 24. PMID: 32830538; PMCID: PMC7642889.
  • Guessoum O, Zainab M, Sequeira‐Lopez MLS, Gomez RA. Proliferation does not contribute to murine models of renin cell recruitment. Acta Physiol (Oxf). 2020;230(3):e13532. doi:10.1111/apha.13532.
  • Guessoum O, de Goes Martini A, Sequeira-Lopez MLS, Gomez RA. Deciphering the Identity of Renin Cells in Health and Disease. Trends Mol Med. 2020 Nov 5:S1471-4914(20)30264-1. doi: 10.1016/j.molmed.2020.10.003. Epub ahead of print. PMID: 33162328.
  • Martinez MF, Martini AG, Sequeira-Lopez MLS, Gomez RA. Ctcf is required for renin expression and maintenance of the structural integrity of the kidney. Clin Sci (Lond). 2020 Jul 17;134(13):1763-1774. doi: 10.1042/CS20200184. PMID: 32619009.
  • Watanabe H, Belyea BC, Paxton RL, Li M, Dzamba BJ, DeSimone DW, Gomez RA, Sequeira-Lopez MLS. Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis. Circ Res. 2021 Jul 9;129(2):262-276. doi: 10.1161/CIRCRESAHA.120.318711. Epub 2021 May 17. PMID: 33993729; PMCID: PMC8273135.
  • Belyea BC, Santiago AE, Vasconez WA, Nagalakshmi VK, Xu F, Mehalic TC, Sequeira-Lopez MLS, Gomez RA. A primitive type of renin-expressing lymphocyte protects the organism against infections. Sci Rep. 2021 Mar 31;11(1):7251. doi: 10.1038/s41598-021-86629-w. PMID: 33790364; PMCID: PMC8012387.
  • Watanabe H, DeGoes Martini A, Brown E, Liang X, Medrano S, Goto S, Narita I, Arend L, Sequeira-Lopez MLS, Gomez RA. Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans. JCI Insight 2021 Dec 22;6(24):e154337. doi: 10.1172/jci.insight.154337. PMCID: PMC8783690. Featured cover IF= 8.31
  • Kessel F, Steglich A, Hickmann L, Lira-Martinez R, Gerlach M, Sequeira-Lopez MLS, Gomez RA, Hugo C, Todorov V. Patterns of differentiation of renin lineage cells during nephrogenesis. Am J Physiol Renal Physiol 321(3):F378-F388, 2021. IF=3.19 Featured cover.
  • Baldelomar, EJ; Charlton, JR; Bennett, KM. Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging. Am J Physiol Renal Physiol. 2022 Nov 1;323 (5):F602-F611. PMID: 36049066.

 

Abstracts and talks

  • Eugene E Lin, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. RBP-J controls the fate of the kidney vasculature. Poster presented at High Blood Pressure Research 2012 Scientific Sessions, September, 2012, Washington, DC, USA
  • Zubaida Saifudeen, Jiao Liu, Yuwen Li, Thomas Carroll and Samir S. El-Dahr. P53 Regulates Progenitor Cell Renewal in the Nephrogenic Niche of the Developing Kidney. Poster presentation, American Society of Nephrology, San Diego, Nov. 2012.
  • El-Dahr, S. Chromatin-based mechanisms of nephron progenitor cell renewal and fate’ presented at the International Workshop in Developmental Nephrology (IWDN-2013) in Edinburgh, Scotland, June 24-26, 2013.
  • Zubaida Saifudeen. p53 in Nephron Differentiation. Invited speaker, American Society of Nephrology, Atlanta, Nov. 2013.
  • Eugene E Lin, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Foxd1+ stromal cells, the required progenitor for renal vascular development. Oral presentation at High Blood Pressure Research 2013 Scientific Sessions, September, 2013, New Orleans, LA, USA.
  • Eugene E Lin, Ellen S Pentz, Minghong Li, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. The Notch signaling pathway regulates the fate of renal FOXD1+ stromal cells and their descendants. Poster presentation at High Blood Pressure Research 2014 Scientific Sessions, September, 2014, San Francisco, CA, USA
  • Lin EE, Sequeira-Lopez MLS, Gomez RA. The Notch signaling pathway regulates the fate of renal FOXD1+ stromal cells and their descendants. Poster presentation at High Blood Pressure Research 2014 Scientific Sessions, September, 2014, San Francisco, CA, USA.
  • Belyea BC, Xu F, Sequeira-Lopez MLS, Gomez RA. Jagged1 and Morphological Integrity of the Kidney. September 2014. High Blood Pressure Research Conference. San Francisco, California. Poster presentation.
  • Lin EE, Pentz ES, Sequeira-Lopez MLS, Gomez RA. Foxd1+ stromal cells: the progenitors for kidney vascular development. Oral presentation at the National Kidney Foundation’s Spring Clinical Meetings, 2015.
  • Silvia Medrano, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Hypoxia and kidney vascular pathology. Poster presentation at the 27th Annual Children’s Hospital Research Symposium, University of Virginia, Charlottesville, VA, USA. May 28, 2015.
    Lin EE, Pentz ES, Sequeira-Lopez MLS, Gomez RA. Foxd1+ stromal cells: the progenitors for kidney vascular development. Oral presentation at the Nephrology Young Investigator’s Forum, Mid-Atlantic Regional, 2015.
  • Belyea BC, Xu F, Sequeira-Lopez MLS, Gomez RA. Loss of Jagged1 in Renin Progenitors Leads to Focal Kidney Fibrosis. July 2015. International Workshop on Developmental Nephrology. Snowbird, Utah. Poster Presentation
  • Maria Florencia Martinez, Ellen Pentz, Silvia Medrano, Masafumi Oka, Mazhar Adli, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Super-Enhancers in the renin cell. Oral presentation at the 28TH Annual Research Symposium, CHRC, UVA. May 2016.
  • Evan Brown, Stephen Turner, Alex Koppel, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez. Use of single cell RNA-sequencing for characterizing renin cell populations. Poster presentation at the 28TH Annual Research Symposium, CHRC, UVA. May 2016.
  • Silvia Medrano, Evan Brown, Maria Florencia Martinez, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Use of a CRISPR/Cas9 system for renin cell lineage specification. Poster presentation at the 28TH Annual Research Symposium, CHRC, UVA. May 2016.
  • Masafumi Oka, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez. Renin cells contribute to vascular pathology in renin deficient mice. Poster presentation at the 28TH Annual Research Symposium, CHRC, UVA. May 2016.
  • Abate, HW; Pearl, VM; Sequeira-Lopez, ML; Charlton, JR. The duration of nephrogenesis is not compromised by premature birth in mice. Poster presentation. University of Virginia’s Children’s Hospital Research Day, 2016.
  • Maria F Martinez, Silvia Medrano, Masafumi Oka, Ellen S Pentz, Allan W Dickerman, Mazhar Adli, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Enhancer Repertoires that Define Renin Cell Identity. Oral presentation. Council on Hypertension, AHA Meeting 2016.
  • Masafumi Oka, Silvia Medrano, Maria Luisa Sequeira-Lopez, Robert Ariel Gomez. Cells Programmed For The Renin Phenotype Contribute To Vascular Pathology In Renin Deficient Mice. Oral presentation. Council on Hypertension, AHA Meeting 2016.
  • Silvia Medrano, Evan Brown, Maria F Martinez, Maria Luisa S Sequeira-Lopez, R Ariel Gomez. Use of a CRISPR/Cas9 System for Specification of the Renin Cell Phenotype. Poster presentation. Council on Hypertension, AHA Meeting 2016.
  • Vidya K. Nagalakshmi, Minghong Li, R. Ariel Gomez, Maria Luisa S. Sequera-Lopez. Cell Fate Changes During Tubular Damage and Regeneration in the Mouse Kidney. Oral presentation. Council on Hypertension, AHA Meeting 2016.
  • Maria Luisa S. Sequeira Lopez, Brian C. Belyea, Rajwinderjit Kaur, Silvia Medrano and R. Ariel Gomez. CD44 and CD44+ cells are dispensable for the recruitment of renin expressing cells. Oral presentation. Council on Hypertension, AHA Meeting 2016.
  • Laws, J; Abate, HW; Pearl, VM; Sequeira-Lopez, ML; Charlton, JR. Early Cessation of Nephrogenesis in Mouse Model of Prematurity, Submitted to American Society of Nephrology’s annual meeting in November 2016.
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