Publications

Yamaguchi H, Smith JP, Guessoum O, Daga D, Yamaguchi M, Almeida LF, Matsuoka D, Watanabe H, Medrano S, Gomez RA, Sequeira-Lopez MLS. Krüppel-like factor 2 regulates renin expression in mature juxtaglomerular cells. Am J Physiol Renal Physiol. 2026 Apr 1;330(4):F410-F421. doi: 10.1152/ajprenal.00416.2025. Epub 2026 Feb 19. PMID: 41711369.
Hill RZ, Nelson JW, Gyarmati G, Medrano S, Shirvan S, McCormick JA, Burquez S, Ahmed J, Eng DG, Wysocki J, Dubin AE, Servin-Vences MR, Lakshmanan A, Gomez RA, Sequeira-Lopez MLS, Shankland SJ, Batlle D, Miner JH, Peti-Peterdi J, Patapoutian A. Renal PIEZO2 is an essential regulator of renin. 2026 Jan 8;189(1):161-178.e22. doi: 10.1016/j.cell.2025.11.013. Epub 2025 Dec 4. PMID: 41349545; PMCID: PMC12695021.
De Almeida LF, Smith JP, Yamaguchi M, Medrano S, Martini A, Matsuoka D, Juśkiewicz ZJ, Isakson BE, Yamaguchi H, Silva DT, Wagamon T, Sequeira-Lopez MLS, Gomez RA. Hypoxia-Induced Metabolic Reprogramming and Markings of Cell Fate in Concentric Arterial Hypertrophy. bioRxiv [Preprint]. 2025 Jul 14:2025.07.09.663881. doi: 10.1101/2025.07.09.663881. PMID: 40791538; PMCID: PMC12338582.
Yamaguchi M, Yamaguchi H, Smith JP, de Almeida LF, Matsuoka D, Martini AG, Wilmsen SM, Hao S, Tainaka K, Medrano S, Sequeira Lopez MLS, Gomez RA. Renin Cells Drive Kidney Neurovascular Development and Arterial Remodeling when Renin Activity is Deficient. bioRxiv [Preprint]. 2025 Jul 11:2025.07.08.663706. doi: 10.1101/2025.07.08.663706. PMID: 40672316; PMCID: PMC12265566.
Lucas Ferreira de Almeida, Ulrich Wenzel, A. H. Jan Danser, Giuseppe Lembo, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez. Balancing blood pressure targets and kidney health: The potential risk of kidney disease due to concentric arterial and arteriolar hypertrophy from renin-angiotensin-aldosterone inhibitors. Hypertension (Dallas, Tex : 1979). 2026 Mar;83:e26125.
Yamaguchi H, Guagliardo NA, Bell LA, Yamaguchi M, Matsuoka D, Xu F, Smith JP, Diagne M, Condron S, Almeida LF, Medrano S, Barrett PQ, Nieh EH, Gomez RA, Sequeira-Lopez MLS. Calcium Oscillations Within Juxtaglomerular Cell Clusters Control Renin Release. Circ Res. 2025;137(8):1051-1068. doi: 10.1161/CIRCRESAHA.125.326541.
Medrano S, Almeida LF, Ruiz-Perez F, Gutierrez-Hernandez A, Yamaguchi H, Matsuoka D, Yamaguchi M, Smith JP, Wagamon T, Sequeira-Lopez MLS, Gomez RA. Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse. bioRxiv [Preprint]. 2025.05.02.651896. doi: 10.1101/2025.05.02.651896.
Jun-Yi Z, Fu Y, van de Leemput J, Yu J, Li J, Ray PE*. Han Z*. HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte death in HIV-related kidney diseases. Dis Model Mech doi:10.1242/dmm.052178, 2025 PMCID PMC12352291 * Co-corresponding authors
Ray PE, Griffin MD. The CX3CR1/CX3CL1 (fractalkine) pathway in IgA vasculitis nephritis: guilty party or innocent bystander? Pediatr Res. 2026 Feb;99(2):395-397. doi: 10.1038/s41390-025-04385-3. Epub 2025 Sep 23. PMID: 40987826; PMCID: PMC12956588.
Rumpel JA, Perazzo S, Ray PE. Serum Creatinine: Beyond Renal Function as a Biomarker of Adverse Outcomes in Premature Neonates. Pediatr Res, in press 2026.
Dailey RK, Cwiek A, Hamil LC, Timberline S, Kameshwar AKS, Suzuki M, Isaac J, deRonde K, Conaway M, Bennett KM, Baldelomar EJ, Hoch MR, Reidy KJ, Charlton JR. Preterm Birth Increases Susceptibility to Hyperglycemia-Induced Kidney Injury With Sex-Specific Differences in Structural and Molecular Responses. Endocrinol Diabetes Metab. 2026 May;9(3):e70223. doi: 10.1002/edm2.70223. PubMed PMID: 42008787; PubMed Central PMCID: PMC13095165.
Li T, Cochran A, Xu Y, Charlton JR, Bennett KM, Timberline SM, Dailey RK, Jannath SY, Baldelomar EJ, Hoch MR, Wu T. AutoGlom: software tool for segmentation and analysis of magnetic resonance images of the kidney. Am J Physiol Renal Physiol. 2026 Jan 1;330(1):F46-F59. doi: 10.1152/ajprenal.00325.2025. Epub 2025 Nov 20. PubMed PMID: 41264403; PubMed Central PMCID: PMC13008130.
Baldelomar EJ, Charlton JR, Keilhoz S, Kohn B, Wilson LD, Xiong LI, Garfinkel A, Bennett KM. Measuring nephron number in the healthy and diabetic rat kidney in vivo using MRI without contrast agents. Am J Physiol Renal Physiol. 2026 Jun 1;330(6):F643-F652. doi: 10.1152/ajprenal.00088.2026. Epub 2026 Apr 17. PubMed PMID: 41995842
Hart M, Kumar M, Goswami HB, Harris WT, Skopelja-Gardner S, Swiatecka-Urban A (2025) Cystic Fibrosis-Related Kidney Disease˗ Emerging Morbidity and Disease Modifier. Pediatr Nephrol. 2025 Dec;40(12):3605-3614. PMID: 40095037. PMCID: PMC10843793. doi.org/ 10.1007/s00467-025-06715-3.
Yavuz H, Kumar M, Goswami HB, Erdbruegger U, Harris WT, Skopelja-Gardner S, Gerber M, Swiatecka-Urban A (2025) Diagnosis and Emerging Biomarkers of Cystic Fibrosis-Related Kidney Disease (CFKD). Clin. Med. 2025, 14(15), 5585. PMCID:PMC12347376. doi.org/10.3390/jcm14155585.
Smith JP, Paxton R, Medrano S, Sheffield NC, Sequeira-Lopez MLS, Gomez RA. Inhibition of Renin Expression Is Regulated by an Epigenetic Switch From an Active to a Poised State. Hypertension 2024 July. doi:10.1161/HYPERTENSIONAHA.124.22886.
LeRoy NJ, Smith JP, Zheng G, Rymuza J, Gharavi E, Brown DE, Zhang A, Sheffield NC. Fast clustering and cell-type annotation of scATAC data using pre-trained region embeddings. Nucleic Acids Research Genomics and Bioinformatics. Volume 6, Issue 3, September 2024, lqae073. doi: 10.1093/nargab/lqae073.
Medrano S, Yamaguchi M, Almeida LF, Smith JP, Yamaguchi H, Sigmund CD, Sequeira-Lopez MLS, Gomez RA. An efficient inducible model for the control of gene expression in renin cells. Am J Physiol Renal Physiol. 2024 Sep 1;327(3):F489-F503. doi: 10.1152/ajprenal.00129.2024. Epub 2024 Jul 11. PMID: 38991008; PMCID: PMC11460331.
Yamaguchi M, Almeida LF, Yamaguchi H, Liang X, Smith JP, Medrano S, Sequeira-Lopez MLS, Gomez RA. Transformation of the Kidney into a Pathological Neuro-Immune-Endocrine Organ. Circ Res. 2024 Oct 25;135(10):1025-1027. doi: 10.1161/CIRCRESAHA.124.325305. Epub 2024 Oct 1. PMID: 39351666; PMCID: PMC11502242.
Ray PE. Role of rh-IGF/IGFBP-3 in the postnatal kidney maturation of preterm pigs: Not so simple. Pediatr Res 96 (7): 1543- 1544, 2024. PMID39134761; PMCID:PMC 11772239.
Rutledge AD, Griffin RL, Vincent K, Askenazi DJ, Segar JL, Kupferman JC, Rastogi S, Selewski DT, Steflik HJ, Neonatal Kidney C. Incidence, Risk Factors, and Outcomes Associated With Recurrent Neonatal Acute Kidney Injury in the AWAKEN Study. JAMA Netw Open. 2024;7(2):e2355307. PMID: 38329754; PMCID: PMC10853837.
Zapata HA, Todurkar N, Favel K, Griffin RL, Starr MC, Charlton JR, McAdams RM, Askenazi D, Kulkarni T, Menon S, Mammen C, Harer MW. Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT). J Perinatol. 2025 Jan;45(1):85-93. doi: 10.1038/s41372-024-02143-7. Epub 2024 Oct 11. PubMed PMID: 39390245; PubMed Central PMCID: PMC11881105.
Charlton JR, Selewski DT, Harer MW, Askenazi DJ, Starr MC, Guillet R. Multidisciplinary collaboration to improve neonatal kidney health. Nat Rev Nephrol. 2025 Jan;21(1):1-2. doi: 10.1038/s41581-024-00895-1. PubMed PMID: 39363019; PubMed Central PMCID: PMC11923768.
Sanderson K, Griffin R, Anderson N, South AM, Swanson JR, Zappitelli M, Steflik HJ, DeFreitas MJ, Charlton J, Askenazi D. Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm. Pediatr Res. 2024 Aug;96(3):740-749. doi: 10.1038/s41390-024-03102-w. Epub 2024 Mar 4. PubMed PMID: 38438550; PubMed Central PMCID: PMC11371939.
DeFreitas MJ, Griffin R, Sanderson K, Nada A, Charlton JR, Jetton JG, Kent AL, Guillet R, Askenazi D, Abitbol CL. Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study. Am J Perinatol. 2024 Apr;41(5):649-659. doi: 10.1055/a-1780-2249. Epub 2022 Feb 23. PubMed PMID: 35196719; PubMed Central PMCID: PMC10981551.
Zhang A, Haywood NS, Money DT, Byler MR, Osuru HP, Atluri N, Laubach VE, Mehaffey JH, Charlton JR, Lunardi N, Kron IL, Teman NR. Rodent Model of Cardiopulmonary Bypass Demonstrates Systemic Inflammation and Neuromarker Changes. J Surg Res. 2024 Nov;303:780-787. doi: 10.1016/j.jss.2024.09.041. Epub 2024 Oct 30. PubMed PMID: 39471762; PubMed Central PMCID: PMC11602341.
Baldelomar EJ, Zhang H, Thorek D, Charlton JR, Walker PD, Wilson LD, Emoto KC, Clavijo Jordan V, Reichert DE, Shoghi K, Bennett KM. Development and Use of Human Recombinant (64)Cu-rHCF as a Kidney Glomerulus-Targeted Contrast Agent for Positron Emission Tomography. ACS Appl Bio Mater. 2024 Oct 21;7(10):6392-6397. doi: 10.1021/acsabm.4c01027. Epub 2024 Sep 6. PubMed PMID: 39241192; NIHMSID:NIHMS2061096. PMCID in progress.
Vuong KT, Liberio BM, Schwartz SR, Menon S, Mohamed TH, Soranno DE, Johnson KS, Jetton JG, Merrill KA, Hanna M, Starr MC, Selewski DT, Steflik HJ. Neonatal Kidney Health Consensus Workshop. Expanded discussion of kidney health monitoring for critically ill term and late preterm infants after acute kidney injury: a report from the Neonatal Kidney Health Consensus Workshop. Pediatr Nephrol. 2025 Apr 15;. doi: 10.1007/s00467-025-06757-7. [Epub ahead of print] PubMed PMID: 40232498. PMCID in progress.
Gorga SM, Beck T, Chaudhry P, DeFreitas MJ, Fuhrman DY, Joseph C, Krawczeski CD, Kwiatkowski DM, Starr MC, Harer MW, Charlton JR, Askenazi DJ, Selewski DT, Gist KM. Framework for Kidney Health Follow-Up Among Neonates With Critical Cardiac Disease: A Report From the Neonatal Kidney Health Consensus Workshop. J Am Heart Assoc. 2025 Mar 18;14(6):e040630. doi: 10.1161/JAHA.124.040630. Epub 2025 Mar 13. Review. PubMed PMID: 40079314. PMCID in progress
Starr, MC; Harer, MW; Steflik, HJ: Gorga, S; Ambalavanan, N; Beck, TM, Chaudhry, PM; Chmielewski, JM; Defreitas, MJ; Fuhrman, DY; Hanna M, Joseph, C; Kwiatkowski, DM; Krawczeski, CD, Liberio, BM; Menon, S, Mohamed, TH; Rumpel, JA; Sanderson, KR; Schuh, MP; Segar, JL; Slagle, CL; Soranno, DE; Vuong, KT; Charlton, JR; Gist, KM; Askenazi, DJ; Selewski, DT; on behalf of the Neonatal Kidney Health Consensus Workshop. Recommendations for Kidney Health Monitoring in Neonatal Intensive Care Unit Graduates: A Modified Delphi Consensus Statement. JAMA Netw Open. 2024. Sep 3;7(9):e2435043.PMCID in progress.
Cwiek, A; Dailey, RK; Suzuki, M; Sista Kameshwar, AK; Isaac, J; deRonde, K; Conaway, M; Bennett, KM; Li,T; Wu, T; Hoch, M; Price, RJ; Hirschi, KK: Reidy, KJ; Charlton, JR*. Preterm birth increases susceptibility to hyperglycemia-induced glomerular alterations in the kidney of male mice. Sci Rep. 2025 May 29;15(1): 18934. PMID: 40442182. PMCID: PMC12122990. MCID: PMC12122990.
Xue B, Khoroshevskyi O, Gomez RA, Sheffield NC. Opportunities and challenges in sharing and reusing genomic interval data. Front Genet. 2023 Mar 20;14:1155809. doi: 10.3389/fgene.2023.1155809. PMID: 37020996; PMCID: PMC10067617.
Anjum H, Yacu G, Medrano S, Gomez RA, Sequeira-Lopez MLS, Quaggin SE, Finer G. The transcription factor Tcf21 is required for specifying Foxd1 cells to the juxtaglomerular cell lineage. bioRxiv [Preprint]. 2024 Mar 29:2024.03.25.586641. doi: 10.1101/2024.03.25.586641. PMID: 38585851; PMCID: PMC10996550.
Almeida LF, Ariel Gomez R, Sequeira-Lopez MLS. Elusive and Heterogenous Nature of Renin Cells. Hypertension. 2024 Feb;81(2):203-205. doi: 10.1161/HYPERTENSIONAHA.123.21372. Epub 2023 Sep 26. PMID: 37750306; PMCID: PMC10840598.
Silvia Medrano, Manako Yamaguchi, Hiroki Yamaguchi, Lucas Ferreira de Almeida, Curt D. Sigmund, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez. An efficient inducible model for the control of gene expression in renin cells. bioRxiv 2024.03.26.585202; doi: https://doi.org/10.1101/2024.03.26.585202.
Vidal E, Ray PE. Acute kidney injury during the first week of life: time for an update? Pediatr Nephrol. 2024. Epub 2024/02/09. doi: 10.1007/s00467-024-06310-y. PubMed PMID: 38332124.
Ray PE. Continuous kidney replacement therapy in critically ill children: heparin vs citrate. Pediatr Res. 2024. Epub 2024/05/14. doi: 10.1038/s41390-024-03238-9. PubMed PMID: 38740869.
Hejenkowska ED, Mitash N, Donovan JE, Chandra A, Bertrand C, De Santi C, Greene CM, Mu F, Swiatecka-Urban A (2023). TGF-β1 inhibition of ACE2 mediated by miRNA uncovers novel mechanism of SARS-CoV-2 pathogenesis. Journal Innate Immun (2023) 15(1): 629-646. PMID: 37579743. DOI: 10.1159/000533606 IF 7.1.