Journal Club Presentation Archive
Fall 2019
December 03, 2019 | Elizabeth Gonye, Pharmacology Grad Student, Douglas Bayliss Lab | Paper Presented: A cautionary tale for cancer drug development. Lin, et. al., Sci.Transl.Med (2019) | Mentor: Kevin Lynch
November 19, 2019 | Clint Upchurch, Pharmacology Grad Student, Norbert Leitinger Lab| Paper Presented: Mammalian YRNAs are modified at discrete guanosine residues with N-glycans. Ryan A. Flynn, et. al. BioRxiv 787614; doi: https://doi.org/10.1101/787614.|Mentor: Kevin Lynch
November 12, 2019 | Andrew Heindel, Pharmacology Grad Student, Ken Hsu Lab | Paper Presented: A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles. Sehyun Chae, et. al. Experimental & Molecular Medicine, 50:129 (2018) | Mentor: Paula Barrett
November 05, 2019 | Philip Seegren, Pharmacology Grad Student, Bimal Desai Lab | Paper Presented: Mitochondrial Ca2+ Uptake InducesCyclic AMP Generation in the Matrix and Modulates Organelle ATP Levels. Guilietta Di Benedetto, et. al. Cell Metabolism, 17: 965-975 (2013) | Mentor: Paula Barrett
October 29, 2019 | Adishesh Narahari, Pharmacology Grad Student, Douglas Bayliss Lab | K-ATP Channels Drive the Powerhouse | Paper Presented: Identification of an ATP-Sensitive potassium channel in mitochondria. Angela Paggio, et. al. Nature 572: 609-628 (2019) | Mentor: Paula Barrett
October 22, 2019 | Mitch Granade, Pharmacology Grad Student, Thurl Harris Lab | Paper Presented: Identification, Characterization and Applications of a Global Tyrosine Chemical Probe. Adam L Borne, Jeffrey W. Brulet, Heung Sik Hahm and Emmanuel K. Toroitich | Independent Research Presentation
October 08, 2019 | Adam Borne, Pharmacology Grad Student, Ken Hsu Lab | Paper Presented: Identification, Characterization and Applications of a Global Tyrosine Chemical Probe. Adam L Borne, Jeffrey W. Brulet, Heung Sik Hahm and Emmanuel K. Toroitich | Independent Research Presentation
October 01, 2019 | Brittany Martinez, Pharmacology Grad Student, Michelle Bland Lab | Paper Presented: Toll signaling in the Drosophila larval fat body shifts programs of anabolic lipid metabolism and dysregulates nutrient storage. Martínez, B.A., Hoyle, R.G., Yeudall, S., Leitinger, S., and Bland, M.L. | Independent Research Presentation
September 24, 2019 | Brandon Podyma, Neuroscience Grad Student/PSTG, Christopher Deppman Lab | Paper Presented: The p75 Neurotrophin Receptor Integrates Energy Homeostasis and Circadian Timing | Paper Presented: The p75 Neurotrophin Receptor in AgRP Neurons is Necessary for Homeostatic Feeding and Food Anticipation. Podyma B, Johnson DA, Sipe L, Remcho TP, Battin K, Liu Y, Yoon SO, Deppmann CD, Güler AD. In preparation | Independent Research Presentation
September 17, 2019 | Katelyn Ahern, Pharmacology Grad Student, Thurl Harris Lab | Paper Presented: A Novel Approach to Quantifying Oxidized Lipids by Targeted Mass Spectrometry |Paper Presented: Regioisomer-independent quantification of fatty acid oxidation products by HPLC-ESI-MS/MS analysis of sodium adducts. Ahern KW, Serbulea V, Wingrove CL, Palas ZT, Leitinger N, Harris TE. Scientific Reports (2019) | Independent Research Presentation
Fall 2020
November 10, 2020 | Matthew Ritger, Pharmacology Grad Student, Mark Beenhakker’s Lab | Paper Presented: Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws. Soohong Min, et al . Cell Reports, 29, 2192-220 (2019) | Mentor: Mark Beenhakker
November 03, 2020 | Claire Ruddiman, Pharmacology Grad Student, Brant Isakson’s Lab | Paper Presented: Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow. Nephtali Marina , et al . Nature Communications, 11: 131(2020) | Mentor: Mark Beenhakker
October 27, 2020 | Catherine Doyle, Pharmacology Grad Student, Bimal Desai’s Lab | Paper Presented: HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Venkat Giri Magupalli, et al . Science, 369, (2020) | Mentor: Michael Scott
October 13, 2020 | Yuntian Guan, Pharmacology Grad Student, Zen Yan’s Lab | Paper Presented: A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis. Chao Quan, et al . Nature Communications, 11: 2186 (2020) | Mentor: Michael Scott
October 06, 2020 | Jessica Hatter, Pharmacology Grad Student, Michael Scott’s Lab | Paper Presented: Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve. Elizabeth A. Davis, et al . Current Biology, 30, 1-9 (2020). | Mentor: Michael Scott
September 29, 2020 | Tatianna Coverdell, Pharmacology Grad Student, John Campbell’s Lab | Paper Presented: Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Pradeep S. Rajendran, et al . Nature Communications, (10)1944 (2019) | Independent Research Presentation
September 22, 2020 | Scott Yeudall, Pharmacology Grad Student, Norbert Leitinger’s Lab | Paper Presented: Dichotomous engagement of HDAC3activity governs inflammatory responses. Hoang C.B. Nguyen, et al. Nature, 584, 286-290 (2020) | Independent Research Presentation
September 15, 2020 | Motteo Ottolini, Pharmacology Grad Student, Swapnil Sonkusare’s Lab | Paper Presented: Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity. Matteo Ottolini, et al. Circulation, 141: 1318-1333 (2020) | Independent Research Presentation
Spring 2020
May 05, 2020 | Bimal Desai, PhD, Associate Professor of Pharmacology, UVA | Immunology of COVID-19, Part II | Special Journal Club Series: Discussing Topics Related to COVID-19
April 28, 2020 | Bimal Desai, PhD, Associate Professor of Pharmacology, UVA | Immunology of COVID-19 | Special Journal Club Series: Discussing Topics Related to COVID-19
April 21, 2020 | Kevin Lynch, PhD, Professor of Pharmacology, UVA | The Rise of Small Molecule Anti-Viral Medicines | Special Journal Club Series: Discussing Topics Related to COVID-19
April 14, 2020 | Kevin Lynch, PhD, Professor of Pharmacology, UVA | Virology And The Advent of Molecular Biology | Special Journal Club Series: Discussing Topics Related to COVID-19
March 03, 2020 | Merci Best, Pharmacology Grad Student, George Bloom’s Lab | Paper Presented (unpublished work): Bidirectional Regulation Between Tau and the Axon Initial Segment in an Alzheimer’s Disease Model | Independent Research Presentation
February 25, 2020 | Anders Nelson, Pharmacology Grad Student, Jeff Saucerman’s Lab | Paper Presented (unpublished work): Mapping MBNL Signaling Regulation of Cardiac Myofibroblast Activation | Independent Research Presentation
February 18, 2020 | Brady Barron, Pharmacology Grad Student, Kodi Ravichandran’s Lab | Paper Presented: Macrophage Metabolism of Apoptic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. Arif Yurdagul, et al. Cell Metabolism, 31: 1-16 (2020) | Independent Research Presentation
February 11, 2020 | Roberto Mendez, Chemistry Grad Student/PSTG, Ken Hsu’s Lab | Paper Presented: The dTAG System for Immediate and Target Specific Protein Degradation. Behnam Nabet, et al. Nature Chemical Biology. 14: 431-441 (2018) | Independent Research Presentation
Fall 2021
November 30, 2021 | Merci Best, Pharmacology Grad Student, George Bloom’s Lab | Paper Presented (unpublished work): Precursors of Neurofibrillary Tangles Hyperactivate Cyclin-Dependent Kinase 5-Mediated Lysosomal Degradation of Tripartite Motif Containing 46 | Independent Research Presentation
November 09, 2021 | Clint Upchurch, Pharmacology Grad Student, Norbert Leitinger’ s Lab | Paper Presented (unpublished work):Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis | Independent Research Presentation
October 07, 2021 | Anders Nelson, Pharmacology Grad Student, Jeff Saucerman’ s Lab | Paper Presented (unpublished work):Network Modeling and High Content Imaging Identifies Cardiac Fibroblast Phenotypic Responses to Candidate Fibrosis Therapeutics | Independent Research Presentation
Spring 2021
April 27, 2021 | Andrew Heindel, Pharmacology Grad Student, Ken Hsu’s Lab | Paper Presented (unpublished work): Discovery of Functional Cysteine Sites in the Proteome using Purine-based Activity-based Probes | Independent Research Presentation
April 13, 2021 | Greg Busey, Pharmacology Grad Student, Bimal Desai’s Lab | Paper Presented: Dorsal Raphe Serotonin Neurons Mediate CO2-Induced Arousal from Sleep. Haleigh R. Smith, at el. The Journal of Neuroscience (2018) | Mentor: Stephen Abbott
April 06, 2021 | Caitlin Pavelec, Pharmacology Grad Student, Norbert Leitinger’s Lab | Paper Presented: Serotonin neurons in the dorsal raphe nucleus encode reward signals. Yi Li , et al . Nature Communications, 7:1053, DOI: 10.1038/ncomms10503 (2016) | Mentor: Stephen Abbott
March 30, 2021 | Binita Rajbanshi, Pharmacology Grad Student, George Bloom’s Lab | Paper Presented: The serotonergic raphe promote sleep in zebrafish and mice. Oikonomou , et al . Neuron, 103(4):686-701 (2019) | Mentor: Stephen Abbott
March 23, 2021 | Sofia Gasperino, Microbiology Grad Student/PSTG, Kodi Ravichandran’s Lab | Paper Presented: Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Ren , et al . Cell, 175, 472-487, (2018) | Mentor: Stephen Abbott
March 16, 2021 | Elizabeth Gonye, Pharmacology Grad Student, Doug Bayliss’s Lab | Paper Presented: Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles. Xu , et al . Science, 370, 313(2020) | Independent Research Presentation
March 02, 2021 | Adam Borne, Pharmacology Grad Student, Ken Hsu’s Lab | Paper Presented (unpublished work): Developing Chemical Biology Pipelines to Advance Sulfur-Triazole Exchange (SuTEx) Chemistry | Independent Research Presentation
February 23, 2021 | Philip Seegren, Pharmacology Grad Student, Bimal Desai’s Lab | Paper Presented: Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing. Philip Seegren , et al . Cell Reports, 33: 108411(2020) | Independent Research Presentation
February 16, 2021 | Mitch Granade, Pharmacology Grad Student, Thurl Harris’s Lab| Paper Presented (unpublished work): The Adenosine Switch: Dynamic Regulation of Adipose Tissue in The Fasted vs. Fed State | Independent Research Presentation
Fall 2022
November 1st, 2022 | Greg Busey, Pharmacology Grad Student, Bimal Desai’s Lab | Paper Presented: Betibeglogene Autotemcel Gene Therapy for Non–β0/β0 Genotype β-Thalassemia. Franco Locatelli, M.D., et al. N Engl J Med 2022; 386:415-427 | Mentored by Dr. Edward Perez-Reyes
October 25th, 2022 | Catherine Doyle, Pharmacology Grad Student, Bimal Desai’s Lab | Paper Presented: Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses. Ying Chan, et al. Sci. Transl. Med.13, eabd3438 (2021) | Mentored by Dr. Edward Perez-Reyes
October 18th, 2022 | Blair Towers, Pharmacology Grad Student, Wendy Lynch’s Lab | Paper Presented: Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity. Yuanyuan Xiao, et al. JCI Insight. 2019;4(13) | Mentored by Dr. Edward Perez-Reyes
October 4th, 2022 | Anders Nelson, Pharmacology Grad Student, Jeff Saucerman’s Lab | Paper Presented: Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation, Mengping Jia, et al., Circulation Research,130:1038-1055 (2022) | Un-mentored Presentation
September 20, 2022 | Elizabeth Gonye, Pharmacology Grad Student, Doug Bayliss’s Lab | Paper Presented: The role of somatosensory innervation of adipose tissues. Yu Wang, et al. Nature, Nature (2022) | Un-mentored Presentation
September 13, 2022 | Merci Best, Pharmacology Grad Student, George Bloom’s Lab | Paper Presented: Intracellular-Tau Dependent Axon Initial Segment Shortening Induced Extracellular Tau Oligomers, Unpublished | Un-mentored Presentation
Spring 2022
April 26, 2022 | Claire Ruddiman, Pharmacology Grad Student, Brant Isakson’s Lab | Paper Presented: Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation, Mengping Jia, et al., Circulation Research,130:1038-1055 (2022) | Un-mentored Presentation
April 12, 2022 | Synphane Gibbs, Pharmacology Grad Student, Eyo Ukpong’s Lab | Paper Presented: Stroke induces disease-specific myeloid cells in the brain parenchyma and pia, Carolin Beuker, et al., Nature Communications,13:945 (2022) | Mentor: Norbert Leitinger
April 05, 2022 | Michael Lemke, Pharmacology Grad Student, Thurl Harris’sLab | Paper Presented: YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload, Toshihide Kashihara, et al., J.Clin Invest, 15;132(6) (2022) | Mentor: Norbert Leitinger
March 29, 2022 | Michael Chi, Pharmacology Grad Student, Tarek Abbas’s Lab | Paper Presented: Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production, Marco Orecchioni, et al., Science, 35: 214-221 (2022) | Mentor: Norbert Leitinger
March 22, 2022 | Yuntian Guan, Pharmacology Grad Student, Zhen Yan’s Lab | Paper Presented: A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion, Aharon Helman, et al., Cell Metabolism (2021) | Mentor: Michelle Bland
March 15, 2022 | Bena Chan, Pharmacology Grad Student, Illya Levental’s Lab | Paper Presented: Inceptor counteracts insulin signaling in β-cells to control glycaemia, Ansarullah, et al., Nature (2021), 590(7845):326-331 | Mentor: Michelle Bland
March 01, 2022 | Jessica Hatter, Pharmacology Grad Student, Michael Scott’s Lab | Paper Presented: Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance, Garron T. Dodd, et al., Sci. Adv. (2021), 7: 1-18 | Mentor: Michelle Bland
Spring 2023
April 18, 2023 | Caitlin Pavelec, Pharmacology Grad Student, Norbert Leitinger’s Lab | Research in Progress Presented: Pannexin 1 Activation Drives Neutrophil Recruitment in a Murine Model of Non-ischemic Heart Failure Induced by Isoproterenol. | Un-mentored Presentation
April 11, 2023 | Madison Failor, Pharmacology Grad Student, Ed Perez-Reyes’ Lab | Paper Presented: Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism. Upadhyayula, P.S., Higgins, D.M., Mela, A. et al. Nat Commun 14, 1187 (2023). | Mentor: Tarek Abbas
April 4, 2023 | Daniel Lank, Pharmacology Grad Student, Thurl Harris’ Lab | Paper Presented: Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death. Scott J. Dixon, et al. Cell, Volume 149, Issue 5, 2012, Pages 1060-1072 | Mentor: Tarek Abbas
March 21, 2023 | Michael Lemke, Pharmacology Grad Student, Thurl Harris’ Lab | Paper Presented: An exercise-inducible metabolite that suppresses feeding and obesity. Li VL, et al. Nature. 2022 Jun;606(7915):785-790. | Mentor: Kevin Lynch
March 14, 2023 | Synphane Gibbs, Pharmacology Grad Student, Upkong Eyo’s Lab | Paper Presented: A Novel Multigene Family May Encode Odorant Receptors: A Molecular Basis for Odor Recognition. Buck, Linda and Axel, Richard. Cell. Vol. 65, 175-187, April 5, 1991 | Mentor: Kevin Lynch
March 07, 2023 | Sze Ham (Bena) Chan, Pharmacology Grad Student, Ilya Levental’s Lab | Paper Presented: Mitochondrial Remodeling and Ischemic Protection by G-protein coupled receptor 35 Agonists. Wyant GA, Yu W, Doulamis IP, Nomoto RS, Saeed MY, Duignan T, McCully JD, Kaelin WG Jr. Science. 2022 Aug 5;377(6606):621-629. | Mentor: Kevin Lynch
February 28, 2023 | David Leace, Pharmacology Grad Student, Ken Hsu’s Lab | Paper Presented: Characterization of interactions of dietary cholesterol with the murine and human gut microbiome. Henry H. Le, Min-Ting Lee, Kevin R. Besler, Janine M. C. Comrie & Elizabeth L. JohnsonNature Microbiology volume 7, pages 1390–1403 (2022) | Mentor: Michelle Bland
February 21, 2023 | Lizzie Van Gorder, Pharmacology Grad Student, Michelle Bland’s Lab | Paper Presented: How the Internally Organized Direction Sense Is Used to Navigate. Eun Hye Park et al. Neuron, 101(2), 2019, 285-293.e5, 0896-6273 | Mentor: Mark Beenhakker
February 14, 2023 | Michael Chi, Pharmacology Grad Student, Tarek Abbas’s Lab | Paper Presented: Multimodal regulatory elements within a hormone specific super enhancer control a heterogeneous transcriptional response. Jackson Hoffman et al., Molecular Cell, 82(4):803-815 (2022) | Mentor: Ira Schulman