Dongfeng Pan, PhD


Dongfeng Pan, PhD

Associate Professor of Radiology and Medical Imaging

BS, Analytical Chemistry, Beijing University, China, 1982
MS, Organic Chemistry, Beijing University, China, 1985
PhD, Organic Chemistry, City University of New York, 1993

University of Virginia
Department of Radiology and Medical Imaging
480 Ray C Hunt Drive
Snyder Building, Room 263
Charlottesville, VA  22903

(434) 243-2893 (office)

Research Interests

The development of novel molecular imaging agents and therapeutics; focus on synthetic chemistry. Current projects include imaging acute inflammation-related neutrophil activation and migration with PET, SPECT and live animal fluorescence modalities with small peptide ligand and developing tumor-targeting molecules as cancer imaging agent and drug carrier.

Research Lab

Targeted Imaging Agents


Synthesis of PECAM-1-specific 64Cu PET imaging agent: evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse. Xiao L, Zhang Y, Yang Z, Xu Y, Kundu B, Chordia MD, Pan D. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4144-7. Epub 2012 Apr 21.

The Synthesis, Characterization and Validation of a Dual PET/Fluorescence 64Cu-DOTA-Heptamethine Cyanine Dye for the Detection of Human Breast Cancer Cells and Tumors Journal of Nuclear Medicine Submitted. Xiao, L., Zhang, Y., Yue, W., Xie, X., Chordia, M., Wang, J., Chung, L., and Pan, D. (2012)

A novel near-infrared fluorescence imaging probe for in vivo neutrophil tracking. Xiao L, Zhang Y, Berr SS, Chordia MD, Pramoonjago P, Pu L, Pan D. Mol Imaging. 2011;11(5):1-11.

Neutrophil targeting heterobivalent SPECT imaging probe: cFLFLF-PEG-TKPPR-99mTc.Zhang Y, Xiao L, Chordia MD, Locke LW, Williams MB, Berr SS, Pan D. Bioconjug Chem. 2010 Oct 20;21(10):1788-93.

Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging. Xiao L, Zhang Y, Liu Z, Yang M, Pu L, Pan D. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3515-7. Epub 2010 May 18.

A novel neutrophil-specific PET imaging agent: cFLFLFK-PEG-64Cu. Locke LW, Chordia MD, Zhang Y, Kundu B, Kennedy D, Landseadel J, Xiao L, Fairchild KD, Berr SS, Linden J, Pan D. J Nucl Med. 2009 May;50(5):790-7. Epub 2009 Apr 16.

Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging. Zhang Y, Kundu B, Fairchild KD, Locke L, Berr SS, Linden J, Pan D. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6876-8. Epub 2007 Oct 12.

Non-invasive imaging of firefly luciferase reporter gene expression using bioluminescence imaging in human prostate cancer models. Li H, Li JZ, Helm GA, Pan D. Biotechnol Appl Biochem. 2007 Apr;46(Pt 4):179-84.

Synthesis of a technetium-99m labeled tricyclic ganciclovir analog for non-invasive reporter gene expression imaging. Zhang Y, Lin J, Pan D. Bioorg Med Chem Lett. 2007 Feb 1;17(3):741-4. Epub 2006 Oct 28.
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