Mark B. Williams, PhD

Williams Orig

Mark B. Williams, PhD

Professor of Radiology and Medical Imaging
Professor of Physics
Professor of Biomedical Engineering

BS, Physics, Grinnell College, 1977
MS, Physics, Wake Forest University, 1983
PhD, Physics, University of Virginia, 1990

University of Virginia
Department of Radiology and Medical Imaging Research
Fontaine Research Park
480 Ray C. Hunt Dr.
Charlottesville, VA  22903

Phone: 434-982-4422

Research Interests

The general field of the research in Dr. Williams’ lab is the development of novel systems for medical imaging. Of particular interest are imaging systems utilizing x-rays (i.e. radiography, x-ray tomosynthesis, x-ray computed tomography (CT)) and/or nuclear medicine (i.e. scintigraphy, gamma ray emission tomosynthesis, single photon emission computed tomography (SPECT), and positron emission computed tomography (PET)). In recent years the focus has been on the development of multimodal hybrid systems that integrate anatomic and functional image sets. Current application areas include breast cancer detection and characterization, intraoperative image guidance, and pre-clinical in vivo imaging. The following projects are ongoing:

  • Dual modality tomographic breast imaging
  • Intraoperative multimodal image guidance
  • Image-guided surgery of non-palpable breast lesion
  • Molecular Imaging for Small Animals

More on Mark Williams’ Research

Research Lab

Imaging Instrumentation Development


FDG-PET Quantification of Lung Inflammation with Image-Derived Blood Input Function in Mice.
Locke LW, Williams MB, Fairchild KD, Zhong M, Kundu BK, Berr SS.
Int J Mol Imaging. 2011.

Intraoperative imaging guidance for sentinel node biopsy in melanoma using a mobile gamma camera.
Dengel LT, More MJ, Judy PG, Petroni GR, Smolkin ME, Rehm PK, Majewski S, Williams MB, Slingluff CL Jr.
Ann Surg. 2011 Apr;4:774-8.

Neutrophil targeting heterobivalent SPECT imaging probe: cFLFLF-PEG-TKPPR-99mTc.
Zhang Y, Xiao L, Chordia MD, Locke LW, Williams MB, Berr SS, Pan D.
Bioconjug Chem. 2010 Oct 20;10:1788-93.

Dual-modality breast tomosynthesis.
Williams MB, Judy PG, Gunn S, Majewski S.
Radiology. 2010 Apr;1:191-8.

Optimization of exposure parameters in full field digital mammography.
Williams MB, Raghunathan P, More MJ, Seibert JA, Kwan A, Lo JY, Samei E, Ranger NT, Fajardo LL, McGruder A, McGruder SM, Maidment AD, Yaffe MJ, Bloomquist A, Mawdsley GE.
Med Phys. 2008 Jun;6:2414-23.

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