Menu Search Icon

Search

Sheynkman Lab

Laboratory of Proteoform Systems Biology

At the Sheynkman Lab, we study disease-relevant protein forms, or “proteoforms,” by integrating cutting-edge analytical and computational approaches from genomics, proteomics, and systems biology. This precision medicine approach is applied in a disease agnostic manner to elucidate proteoform-driven rewiring events in cardiovascular disease, neurological disorders, and cancer.

Simple lab overview

 

Department of Physiology
AI image depicting how biology is inter-related

Research Goals

How human proteomic variation underlies phenotypic variation

Learn More

AI image of research approaches

Approaches

Long Read Transcriptomics Technologies
"Precision" Proteogenomics to characterize protein isoforms
Functional proteomics- Screening for driver proteoforms

Learn More

AI image of disease communities

Disease Communities

We apply our research to a variety of disease communities, including coronary artery disease (CAD), osteoporosis (BMD), chronic obstructive pulmonary disease (COPD), and cancer

Learn More

News View More »

Congrats to Madison on the successful defense of her thesis!

Congrats to our first graduate student, Madison Mehlferber, on successfully defending her thesis in the Sheynkman Lab. Congrats to the new Dr. Mehlferber!  

Congrats to Jennifer on the acceptance of her paper in the Journal of the American Society for Mass Spectrometry

In the study presented by our own, Jennifer Korchak, she presents a targeted proteogenomic approach in which she utilizes our existing long-read proteogenomics pipeline to leverage the long-read RNA sequencing…

Congratulations to Bond on his preprint describing the application of QSI technology!

Congratulations to Bond on his preprint describing the Sheynkman lab's adoption of QSI technology to support the targeted detection of proteoforms.   See the full pre-print here!

Congratulations to our 3rd year students on passing quals!

All of the Sheynkman lab 3rd year graduate students passed this qualification exams this summer! Congratulations to Ph.D. candidates Micah Lehe, Natchanon (Bond) Sittipongpittaya, and Jennifer Korchak!      

The Sheynkman lab at the 2024 ASMS annual conference

The Sheynkman lab will be delivering a talk, as well as presenting 3 posters at the American Society for Mass Spectrometry 2024 annual conference. Micah Lehe will be presenting 0n…

Lab Location

Pinn Hall - Rm. 3043D, 1340 Jefferson Park Avenue, Charlottesville, VA 22908

More Contact Info