Selected Publications
Proteoform medicine: characterizing and targeting protein forms in human disease
Jennifer A. Korchak, S. Stephen Yi, Neil L. Kelleher, Nidhi Sahni, Gloria M. Sheynkman. Nature Reviews Genetics. 2026. 27: 271–291.
LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discovery
Megan D. Schertzer, Julia T. Lewandowski, Emily F. Watts, Will Rosenow, Madison M. Mehlferber, Erin D. Jeffery, Scott I. Adamson, Jocelyne Bruand, Elizabeth Tseng, Yaseswini Neelamraju, Francine E. Garrett-Bakelman, Egor Dolzhenko, David A. Knowles, Gloria Sheynkman. bioRxiv. 2026.
Long-read proteogenomics to connect disease-associated sQTLs to the protein isoform effectors of disease
Abdullah Abood, Larry D. Mesner, Erin D. Jeffery, Mayank Murali, Micah D. Lehe, Jamie Saquing, Charles R. Farber, Gloria M. Sheynkman. The American Journal of Human Genetics. 2024. 111(9): 1914-1931.
Protein sequencing with single amino acid resolution discerns peptides that discriminate tropomyosin proteoforms
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Advances in mass spectrometry instrumentation and methodology for analysis of alternative protein isoforms
Micah D. Lehe, Raghad Almofeez, Erin D. Jeffery, Gloria M. Sheynkman. Journal of Mass Spectrometry. 2026. 61(3): e70024.
Systematic assessment of long-read RNA-seq methods for transcript identification and quantification
F.J. Pardo-Palacios, D. Wang, F. Reese, … M. Jerryd Meade, … Leon Sheynkman, … Gloria M. Sheynkman, A. Mortazavi, A. Conesa, A.N. Brooks. Nature Methods. 2024. 21: 1349-1363.
A systematic benchmark of high-accuracy PacBio long-read RNA sequencing for transcript-level quantification
David Wissel, Madison M. Mehlferber, Khue M. Nguyen, Vasilii Pavelko, Elizabeth Tseng, Mark D. Robinson, Gloria M. Sheynkman. Genome Biology. 2026. 27(1): 110.
Enhanced protein isoform characterization through long-read proteogenomics
Rachel M. Miller, Ben T. Jordan, Madison M. Mehlferber, Erin D. Jeffery, Christina Chatzipantsiou, Simi Kaur, Robert J. Millikin, Yunxiang Dai, Simone Tiberi, Peter J. Castaldi, Michael R. Shortreed, Chance John Luckey, Ana Conesa, Lloyd M. Smith, Anne Deslattes Mays, Gloria M. Sheynkman
