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Sheynkman Lab

Laboratory of Proteoform Systems Biology

At the Sheynkman Lab, we study disease-relevant protein forms, or “proteoforms,” by integrating cutting-edge analytical and computational approaches from genomics, proteomics, and systems biology. This precision medicine approach is applied in a disease agnostic manner to elucidate proteoform-driven rewiring events in cardiovascular disease, neurological disorders, and cancer.

Department of Physiology

Sheynkman Lab Mission

At the Sheynkman Lab, we are working to found a new area of the “Disease Proteoform Systems Biology”, which is a systems biology approach to discover disease-driving “proteoforms” for therapeutic intervention. To accomplish this, we are integrating a unique set of cutting-edge analytical and computational approaches from human disease genetics, genomics, proteomics, and systems and network biology.

Research Goals

To understand how human proteomic variation underlies phenotypic variation

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Approaches

Long Read Transcriptomics Technologies
"Precision" Proteogenomics to characterize protein isoforms
Functional proteomics- Screening for driver proteoforms

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Applications to Disease

We apply our research to a variety of disease communities, including coronary artery disease (CAD), osteoporosis (BMD), chronic obstructive pulmonary disease (COPD), cancer, and the study of acute myeloid leukemia (AML).

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News View More »

Congrats to Micah on Securing an Internship at Genentech!

We’re excited to congratulate Micah, one of our talented graduate students, on securing an internship with Genentech! This incredible opportunity will allow Micah to gain hands-on industry experience and apply…

Dr. Mehlferber Walks the Lawn as Our First PhD Graduate!

A huge congratulations to Madison, the first PhD student to graduate from our lab! Last month, Madison marked this incredible milestone by Walking the Lawn during UVA’s Final Exercises and…

PacBio Revio launches at UVA

Last month, the UVA Genome Analysis and Technology Core (GATC) proudly celebrated the arrival and official launch of the PacBio Revio sequencing platform — a major advancement in long-read sequencing…

Katleyn awarded prestigious Cancer Training Grant!

We are thrilled to share that Katelyn has been awarded a prestigious Cancer Training Grant in recognition of her outstanding potential and dedication to advancing cancer research. This achievement reflects…

Science meets Swordplay – Sheynkman lab fencing outing!

This week, our lab took a break from the bench and tried something a little different—fencing! We traded lab coats for masks and tested our reflexes and coordination in a…

Lab Location

Pinn Hall - Rm. 3043D, 1340 Jefferson Park Avenue, Charlottesville, VA 22908

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