Sheynkman Lab

Laboratory of Proteoform Systems Biology

At the Sheynkman Lab, we study disease-relevant protein forms, or “proteoforms,” by integrating cutting-edge analytical and computational approaches from genomics, proteomics, and systems biology. This precision medicine approach is applied in a disease agnostic manner to elucidate proteoform-driven rewiring events in cardiovascular disease, neurological disorders, and cancer.

Sheynkman Lab Mission

At the Sheynkman Lab, we are working to found a new area of the “Disease Proteoform Systems Biology”, which is a systems biology approach to discover disease-driving “proteoforms” for therapeutic intervention. To accomplish this, we are integrating a unique set of cutting-edge analytical and computational approaches from human disease genetics, genomics, proteomics, and systems and network biology.

Research Goals

To understand how human proteomic variation underlies phenotypic variation

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Approaches

Long Read Transcriptomics Technologies
"Precision" Proteogenomics to characterize protein isoforms
Functional proteomics- Screening for driver proteoforms

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Applications to Disease

We apply our research to a variety of disease communities, including coronary artery disease (CAD), osteoporosis (BMD), chronic obstructive pulmonary disease (COPD), cancer, and the study of acute myeloid leukemia (AML).

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News View More »

Science meets Swordplay – Sheynkman lab fencing outing!

This week, our lab took a break from the bench and tried something a little different—fencing! We traded lab coats for masks and tested our reflexes and coordination in a…

Congrats to our graduate students on receiving their white coats!

Congrats to Katelyn and Raghad on receiving their white coats! We are so excited to have you join the Sheynkman lab and can't wait to see all of the amazing…

Sheynkman lab presents at inaugural RNA retreat

See the schedule of events and the program information here

Molecular Physiology and Biological Physics publishes new magazine!

Check out the magazine here to see all of the great things happening within the department.

Dr. Don Hunt graduates his last graduate student

Dr. Sheynkman had the pleasure to serve on the thesis advisory committee for Dr. Don Hunt's last graduate student, now Dr. Larry Resner! Congratulations!

Lab Location

Pinn Hall - Rm. 3043D, 1340 Jefferson Park Avenue, Charlottesville, VA 22908

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