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Sheynkman Lab

Laboratory of Proteoform Systems Biology

At the Sheynkman Lab, we study disease-relevant protein forms, or “proteoforms”, by integrating cutting-edge analytical and computational approaches from genomics, proteomics, and systems biology. This precision medicine approach is applied in a disease agnostic manner to elucidate proteoform-driven rewiring events in cardiovascular disease, neurological disorders, and cancer.

Proteform Systems Biology

 

Double Helix DNA

Research Goals

How human proteomic variation underlies phenotypic variation

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Orbitrap

Approaches

Long Read Transcriptomics Technologies
"Precision" Proteogenomics to characterize protein isoforms
Functional proteomics- Screening for driver proteoforms

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SQ2

Disease application areas

Cancer - Melanoma
Vascular biology - endothelial cell development

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News View More »

Congratulations to our 3rd year students on passing quals!

All of the Sheynkman lab 3rd year graduate students passed this qualification exams this summer! Congratulations to Ph.D. candidates Micah Lehe, Natchanon (Bond) Sittipongpittaya, and Jennifer Korchak!      

The Sheynkman lab at the 2024 ASMS annual conference

The Sheynkman lab will be delivering a talk, as well as presenting 3 posters at the American Society for Mass Spectrometry 2024 annual conference. Micah Lehe will be presenting 0n…

Madison Mehlferber’s Stem Cell Review Accepted!

Madison's stem cell review titled "Transcription factors and splice factors as interconnected regulators of stem cell fate" got accepted to Current Stem Cell Reports.

Sheynkman lab presents at Gordon Research Conference

Dr. Sheynkman and graduate student Jamie Saquing attended the GRC Post-Transcriptional Gene Regulation conference in Newry, Maine from July 10-15, 2022. Jamie gave a poster presentation of her work on…

Dr. Gloria Sheynkman receives young researcher award at ASMS 2022

Dr. Sheynkman was awarded one of three research awards at the June 2022 American Society for Mass Spectrometry conference in Minneapolis, MN. These awards are given annually to young researchers…

Lab Location

Pinn Hall - Rm. 3043D, 1340 Jefferson Park Avenue, Charlottesville, VA 22908