Position: Primary investigator
B.S. Biochemistry, Notre Dame
PhD Chemistry, Wisconsin
Postdoc, Dana-Farber Cancer Institute
About me: Dr. Sheynkman received her BS in Biochemistry from the University of Notre Dame. She has industry experience from working at Gilead Sciences in the Analytical Development department. She then received her PhD from the University of Wisconsin-Madison where she developed integrative proteogenomics methods to discover human proteomic variation. Dr. Sheynkman was a postdoctoral fellow at the Dana-Farber Cancer Institute and Harvard Medical School, where she developed high-throughput functional proteomics approaches to characterize normal and disease protein isoforms. Most recently, she was recruited to the University of Virginia in the summer of 2020 and is an Assistant Professor with a primary appointment in The Department of Molecular Physiology and Biological Physics.
Position: Senior Research Scientist
B.S., Biochemistry, Hartwick College
PhD, Chemistry, University of Virginia
About me: Since hailing from Dr. Don Hunt’s laboratory, Dr. Jeffery has extensive experience using mass spectrometry applications to facilitate proteomics and answer key research questions. In the Sheynkman lab, we use mass spec for direct detection of novel proteins and peptides that arise from genetic events related to human disease.
Hobbies/Interests: Reading (biographies, mysteries, women in history and science), French and Italian language and culture, spending time with my family and parenting a teenager!
Leon Sheynkman email
Position: Lab Tech/Lab manager/Problem solver extraordinaire
About me: I’ve done a little bit of everything and always interested in learning more.
Dr. David Cooper email
Position: Assistant Professor of Research
Academic Training: I have recently joined the Sheynkman Lab to investigate splice variants of proteins using structural biology. I was trained in X-ray crystallography in the structure group at Purdue University and was lured to the UVa by the research of Dr. Zygmunt Derewenda. About the time my postdoc was ending, the lab became a part of a structural genomics group dedicated to crystallization methods development, and I transitioned to research faculty. When that phase of the Protein Structure Initiative ended, I transitioned to Dr. Wladek Minor’s lab, which was a part of several structural genomics groups. There I was able to branch out of the wet lab and shift the focus of my research to data management for scientific endeavors. I still determine structures using X-ray crystallography, but my calling is to create tools for other researchers.
Madison Mehlferber email
Position: BIMS Graduate Student
About me: Madison received her Bachelor’s degree in Bioinformatics from Saint Vincent College in May of 2019. While she was an undergraduate she participated in the National Institute of Health’s Summer Internship Program working for the National Institute on Deafness and Other Communication Disorders (NIDCD). Following graduation, Madison held a position at the NIH as a post-bac in the National Institute of Dental and Craniofacial Research (NIDCR). She looks forward to the tremendous educational and research opportunities at UVA and in Dr. Sheynkman’s lab.
Shay Iyer email
Position: Undergraduate Research Assistant
Academic training: B,A, Statistical Data Sciences and Biological Sciences, Smith College (class of 2023)
Research interests: Bioinformatics, Devlopmental Biology, Proteogenomics, Systems Biology
Hobbies: Indian classical music, animation and art, marine biology
William Kim email
Position: Undergraduate Researcher
Academic training: BA Statistics (with a concentration in data science) (May 2023)
Research Interest: Bioinformatics and proteogenomics
Hobbies: Guitar and reading
Mayank Murali email
Position: Senior Data Analyst
Academic training: B.Tech in Computer Science and Engineering, VIT
MS in Computer Science and Engineering, Penn State
About me: Mayank received both his bachelor’s and MS degree in CSE. For his MS thesis (from Shao lab at Penn State), he benchmarked de novo metagenomic assemblers for PacBio HiFi long-reads. At Sheynkman lab, he works on developing computational tools to understand the role of RNA in alternative splicing and its effect on proteins.
Hobbies: Outside research and development, he indulges in recreational badminton and soccer.
Jerryd Meade email
Position: Laboratory Specialist
Academic Training: BS in Biochemistry, UVA College at Wise, 2021
Research Interests: Proteogenomics, Evolutionary Biology, and Phylogenomics
Hobbies: Reading, cooking, taking care of my dog Muffin, trading cards
Jennifer Korchak email
Academic Training: Bachelor’s degrees in Biology and Chemistry, University of North Florida
About me: Jennifer received her Bachelor’s degrees in May of 2019. While an undergraduate, she used biochemistry, molecular biology, and analytical chemistry techniques to investigate clinically relevant bacterial natural products. Following graduation, Jennifer worked at the Mayo Clinic in Florida in the Center for Regenerative Medicine as a research technologist from 2019 to 2022. While there, she conducted translational research, manufactured clinical-grade cell products, and developed new regenerative therapeutics. Jennifer is excited to join Dr. Sheynkman’s lab to investigate disease-relevant protein isoforms with an interdisciplinary, systems biology approach.
Vasilii Pavelko email
Position: Data Analyst
Academic Training: Vasilii Pavelko graduated from the University of Vlodimir in 2011 and gained experience in molecular biology methods while working at the Federal Centre for Animal Health. He studied bacterial pathogenicity factors and developed diagnostic methods for bacterial and viral diseases. From 2016 to 2022, he worked as a research scientist at a biotechnology company, Generium, where he was interested in the analytical methods of therapeutic protein production and characterization, including proteoforms. Currently, he is discovering new promising protein isoform-specific targets for therapy using high-throughput biological methods.
Hobbies: board games, apline skiing, trekking
Thalles Lacerda email
Position: Postdoctoral Researcher
Academic Training: BScN from Federal University of Paraiba – UFPB, Brazil
Master´s degree in Molecular and Cellular Biology from UFPB, Brazil
Ph.D in Science (Biochemistry) from Federal University of São Paulo – UNIFESP, Brazil
Postdoc in Physiology from University of São Paulo – USP, Brazil
About Me: Dr. José Thalles Lacerda has experience in mass spectrometry (MS)-based proteomics focusing in de novo sequencing approach for detection of protein isoforms and complete protein sequencing; complex sample analysis for data integration in the biology scenario.
Research Interests: Protein chemistry, MS-based proteomics, de novo peptide sequencing, proteogenomics, protein-protein interaction network, system biology.
Hobbies/Interests: Traveling, outside research, Blues and Jazz music
Micah Lehe email
Academic training: B.S. Biochemistry, Purdue University
Micah graduated with his bachelor’s degree in 2022. During undergrad, he joined a proteomics lab and conducted research on PTM enrichment and detection with mass spectrometry. He joined the Sheynkman lab in 2023, with an interest in leveraging mass spec and other biophysical techniques to study disease-causing protein isoforms.
Hobbies: baking desserts, hiking, reading, and gaming
Natchanon Sittipongpittaya email
Academic training: B.S. Chemistry, University of Virginia
Bond graduated with his bachelor’s degree in 2022. He is a first year graduate student in the Biophysics department. He plans to dive into the technology development arm of Sheynkman Lab, to advance our ability to clone, synthesize, and screen isoforms using the latest technology.
Former lab members
Ben Jordan (Bioinformatician) – Currently a Senior Bioinformatician at the Frederick National Lab for Cancer Research
Jamie Saquing (Post-Bac Researcher) – Currently a BIMS graduate student in Dr. Jeff Saucerman’s lab
Saikat Bandyopadhyay (Senior Data Analyst) – Currently a Senior Data Analyst in Dr. Charles Farber’s lab