The Ai lab specializes in protein engineering and employs interdisciplinary approaches, including biophysics, bioanalytical chemistry, chemical biology, synthetic biology, and optical imaging.
One of our main areas of focus is the development of molecular biosensors that provide insights into cellular and organismal signaling. We employ state-of-the-art techniques such as directed evolution, fluorescence imaging, bioluminescence imaging, synthetic chemistry, genetic screening, and mass spectrometry to unravel complex biological pathways related to redox biology, metabolism, and neuronal activity.
Furthermore, we explore the application of protein-based tools in live cells and rodent models to better understand pathophysiology and develop innovative therapies for conditions like diabetes, Alzheimer’s disease, and cancer. As an emerging direction, we are also working on the development of biosensors that can serve as self-wellness alert devices or diagnostics in resource-limited settings.
We are a collaborative group of passionate protein engineers, chemists, and biologists with expertise in protein engineering and development of molecular biosensors that provide insights into cellular and organismal signaling.
We recognize and respect that our research and learning take place on a campus initially constructed by enslaved African Americans on the land of the Monacan Native Americans.
Ai Engages Students Worldwide During National Chemistry Week and Mole Day Cancer Center provides two new grants, including Trainee Fellowship to Zefan Paper on bioluminescent potassium sensor is published in JACS Paper on amber-emitting luciferase and immunobioluminescence imaging published in JACS Paper on bioluminescent calcium imaging published in Nature Communications
