Antonio Abbate MD PhD

Ruth C. Heede Professor of Cardiology, Medicine- Cardiovascular Medicine

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Faculty Profile CVRC
VA-ART4 Clinical Trials

Dr. Abbate and his interdisciplinary research team developed and executed translational research exploring the impact of innate immunity on cardiovascular disease and injury. They have a focused interest in the role of Interleukin-1 (IL-1) and have been recognized for their novel work on inflammasome-targeted treatments in acute myocardial infarction, heart failure, pericarditis, and myocarditis. Dr. Abbate and his collaborators are currently enrolling eligible participants at the University of Virginia and Virginia Commonwealth University in Virginia Anakinra Response Trial 4 (VA-ART4), their randomized, double-blinded clinical trial exploring the effects of IL-1 blockade on cardiac reserve and cardiorespiratory fitness in patients with ST-segment elevation myocardial infarction (STEMI). With data collected from the NIH-funded VA-ART4 study, Dr. Abbate and his team hope to evaluate the mechanism by which targeted IL-1 blockade may preserve cardiorespiratory fitness and cardiac reserve, ultimately preventing the incidence of new-onset heart failure in patients with STEMI.

• Abbate A, Toldo S, Marchetti C, Kron J, Van Tassell BW, Dinarello CA. Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease. Circ Res. 2020 Apr 24;126(9):1260-1280. doi: 10.1161/CIRCRESAHA.120.315937. Epub 2020 Apr 23. PMID: 32324502; PMCID: PMC8760628.
• Del Buono MG, Garmendia CM, Seropian IM, Gonzalez G, Berrocal DH, Biondi-Zoccai G, Trankle CR, Bucciarelli-Ducci C, Thiele H, Lavie CJ, Crea F, Abbate A. Heart Failure After ST-Elevation Myocardial Infarction: Beyond Left Ventricular Adverse Remodeling. Curr Probl Cardiol. 2022 Apr 20:101215. doi: 10.1016/j.cpcardiol.2022.101215. Epub ahead of print. PMID: 35460680.
• Chiabrando JG, Bonaventura A, Vecchié A, Wohlford GF, Mauro AG, Jordan JH, Grizzard JD, Montecucco F, Berrocal DH, Brucato A, Imazio M, Abbate A. Management of Acute and Recurrent Pericarditis: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Jan 7;75(1):76-92. doi: 10.1016/j.jacc.2019.11.021. PMID: 31918837.
• Del Buono MG, Arena R, Borlaug BA, Carbone S, Canada JM, Kirkman DL, Garten R, Rodriguez-Miguelez P, Guazzi M, Lavie CJ, Abbate A. Exercise Intolerance in Patients With Heart Failure: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019 May 7;73(17):2209-2225. doi: 10.1016/j.jacc.2019.01.072. PMID: 31047010.
• Imazio M, Lazaros G, Gattorno M, LeWinter M, Abbate A, Brucato A, Klein A. Anti-interleukin-1 agents for pericarditis: a primer for cardiologists. Eur Heart J. 2022 Aug 14;43(31):2946-2957. doi: 10.1093/eurheartj/ehab452. PMID: 34528670; PMCID: PMC9375710.
• Medina de Chazal H, Del Buono MG, Keyser-Marcus L, Ma L, Moeller FG, Berrocal D, Abbate A. Stress Cardiomyopathy Diagnosis and Treatment: JACC State-of-the-Art Review. J Am Coll Cardiol. 2018 Oct 16;72(16):1955-1971. doi: 10.1016/j.jacc.2018.07.072. PMID: 30309474; PMCID: PMC7058348.PubMed link