Jonathan R Lindner, MD

Frances Myers Ball Endowed Professor of Medicine
Vice-Chief for Research, Cardiovascular Division

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Lindner CVRC Research Lab

Dr. Lindner leads a multidisciplinary research program that straddles the fields of advanced cardiovascular imaging, cardiovascular physiology, and vascular biology. The laboratory is widely recognized for pioneering contrast ultrasound-based methods for perfusion imaging, molecular imaging, and site-targeted therapy. NIH-sponsored research areas include applying these advanced imaging techniques in pre-clinical and clinical studies to develop and test novel treatments for treating atherosclerosis, improving microvascular health after ischemic injury, and arresting the progression of aortic stenosis. Other NIH-funded research includes the development of novel ultrasound technologies for increasing perfusion in ischemic tissue and site-targeted cardiovascular gene delivery. Dr. Lindner’s research portfolio also includes studying microvascular function and dysfunction, including NASA-sponsored studies for evaluating the effects of long-duration space travel in astronauts.

• Reduced Proteolytic Cleavage of von Willebrand Factor Predisposes to Aortic Valve Thickening and Stenosis.
• Echocardiographic Ischemic Memory Molecular Imaging for Point-of-Care Detection of Myocardial Ischemia.
• Myocardial Infarction Produces Sustained Pro-inflammatory Endothelial Activation in Remote Arteries.
• Coronary Microvascular Dysfunction by Myocardial Contrast Echocardiography in Non-elderly Patients Referred for CT Coronary Angiography.
• Elevated Low-density Lipoprotein Cholesterol Increases Microvascular Endothelial Von Willebrand Factor and Thromboinflammation after Myocardial Infarction.