Assistant Professor, Molecular Physiology and Biological Physics
- Diploma, Biology, Technische Universität Darmstadt
- PhD, Cell Biology, Max Planck Institute for Cell Biology and Genetics
Biophysics, Cell and Developmental Biology
Chromosome segregation and aneuploidy in meiosis and mitosis
All eukaryotic cells divide by assembling a microtubule-based spindle machinery that equally segregates chromosomes between daughter cells. The faithful segregation of chromosomes during cell division is essential as errors in this process have severe implications for development, health and survival of the organism. One major outcome of chromosome segregation errors in mitosis is tumor initiation and progression. Analysis of cancer cell karyotypes revealed that aneuploidy, an abnormal number of chromosomes, is an extremely common feature, with 70 95% of cancers from the most commonly affected organs being aneuploid. Aneuploidy is associated with poor patient prognosis, metastasis, and resistance to chemotherapeutics. Chromosome segregation errors during meiosis, are the leading cause of early pregnancy loss and infertility. Thus, understanding the underlying processes and molecular mechanisms of spindle assembly and chromosome segregation in meiosis and mitosis is of great importance and highly relevant. In our lab we are using a combination of cutting-edge imaging technologies, such as large-scale 3D electron tomography and spinning disc live-cell microscopy, as well CRISPR and other genetic tools to establish the mechanisms and principles of spindle assembly and chromosome segregation during meiosis and mitosis in tissue culture cells, mouse Oocytes and C. elegans embryos.