1/30/2017
[Pinn 5023 (Pharmacology Library)]
1/26/2017
[Pinn 5023 (Pharmacology Library)]
Jan 23 Pharmacology Faculty Search Candidate Seminar by Jay Bikoff
1/23/2017
[Pinn 5023 (Pharmacology Library)]
1/19/2017
[Pinn 5023 (Pharmacology Library)]
12/20/2016
[Pinn (formerly Jordan) 1-14] The Golshani Lab investigates: 1. Cortical network dysfunction in models of autism. We use in-vivo and in-vitro electrophysiological and optogenetic techniques, to understand how changes in connectivity between defined ...
Dec 08 “Simple Sphingolipids; Complex Diseases” – Pharmacology seminar by Tony Futerman, PhD
12/8/2016
[Jordan 1-17] Hosted by Mark Kester. Our laboratory works on sphingolipids, important membrane components. We focus on two main areas: (i) sphingolipid synthesis and signaling, particularly of ceramide, and (ii) sphingolipid storage diseases, with an ...
Nov 10 Pharmacology Seminar by Alyssa Hasty, PhD
11/10/2016
[Jordan 1-17] Hosted by Norbert Leitinger. The Hasty research lab seeks to uncover how obesity increases the risk for diabetes and fatty liver disease. We study how obesity impacts health. The growing worldwide obesity epidemic is frequently linked t...
Oct 27 Pharmacology Seminar by Huaxi Xu, PhD
10/27/2016
[Jordan 1-17] Hosted by Julius Zhu. Our research focuses on the molecular and cellular mechanism underlying the pathogenesis of Alzheimer's disease. Because Sanford-Burnham has an exceptional collaborative environment, which is at the forefront of in...
Oct 13 Pharmacology Seminar by Steven Farber, PhD
10/13/2016
[Jordan 1-17] Hosted by Michelle Bland. Research Interests: Visualization of Lipid Metabolism and Signaling in the Zebrafish: Cells require lipids for the production of signaling molecules, membrane components, and as sources of fuel. Given their utmost necessity for proper cellular function, it is not surprising that defects in lipid metabolism underlie a number of human diseases, including obesity, diabetes, and atherosclerosis. In 2007-08, one-third of US adults and >18% of children (ages 6-19) were classified as obese, with obesity and type 2 diabetes on the rise worldwide. The globalization of the high-fat Western diet and the concurrent rise in the incidence of lipid disorders has provided an impetus to better understand lipid metabolism in the context of metabolic dysfunction. This need to investigate the role of lipids in metabolic disease has also brought into focus questions that remain unanswered in the field. For instance, although the genes involved in cholesterol and fatty acid (FA) uptake in intestinal cells have been identified, their exact mechanisms of action are highly debated or largely unknown. Such gaps in our understanding of these genes and how they function hinders the development of effective therapeutics for lipid disorders and reveals a need to create better approaches to address them. In general, the goal of the Farber lab is to better understand the cell and molecular biology of lipids within digestive organs by exploiting the many unique attributes of the zebrafish larvae. While the zebrafish has been established as a powerful model for the study of early development, few researchers have taken advantage of the accessibility and optical clarity of the embryos and larvae to visualize lipid uptake and processing in vivo. Specifically, the laboratory has focused on studying lipid modifying and transport processes in the developing 6 day old zebrafish larvae. https://emb.carnegiescience.edu/science/faculty/steven-farber