Current Studies

Open to Enrollment

Treating Early Type 2 Diabetes by Reducing Postprandial Glucose Excursions: A Paradigm Shift in Lifestyle Modification (GEM). A Randomized Trial Evaluating the Efficacy and Safety of Control-IQ Technology in Adults with Type 2 Diabetes Using Basal-Bolus Insulin Therapy (2IQP). Adaptive Motif-Based Control (AMBC): Neural Net Implementation of Automated Insulin Delivery. Neural Net Artificial Pancreas (NAP). Using Closed-Loop Artificial Pancreas Technology to Reduce Glycemic Variability and Subsequently Improve Cardiovascular Health in Type 1 Diabetes (AP-CVD).

Trial Title: Using Closed-Loop Artificial Pancreas Technology to Reduce Glycemic Variability and Subsequently Improve Cardiovascular Health in Type 1 Diabetes (AP-CVD).
IRB-HSR#220180
PI: Dr. W. Benjamin Horton, MD
CRC: Lee Hartline

This study will examine cardiovascular effects to your heart while using the artificial pancreas (AP) technology. The AP technology is a system of devices that closely mimics the glucose regulating function of a healthy pancreas. It includes an insulin pump and a continuous glucose monitor (CGM). In this study, we will use the Food and Drug Administration (FDA) approved Tandem t:slim insulin pump with Control-IQ Technology and the FDA approved Dexcom G6 CGM. This study will research if the changes in your blood glucose levels will be reduced and, therefore, reduce some of the cardiovascular biomarkers that represent harmful effects while using the AP. A biomarker is a biological molecule found in blood.

The University of Virginia Center for Diabetes Technology is seeking adults 18-40 years old diagnosed with type 1 diabetes for a research study. The purpose of this study is to examine the cardiovascular effects while using the artificial pancreas (AP) technology.

If you participate in this study:

you may be asked to wear a Tandem t:slim insulin pump with Control-IQ Technology and a CGM for up to 13 weeks or you will be asked to wear only a CGM for 13 weeks.
you will be asked to provide blood samples taken to measure your heart functioning at five different time points in the study. These blood draws will take about 15 minutes to complete.
You will be asked to complete cardiac testing at two different times in the study. This testing will take less than an hour to complete.

The blood samples, cardiac testing, insulin pump supplies and CGM supplies are provided at no-cost. You will need to provide your own insulin. Compensation: $725.00 for study completion

For more information, please email: Lee Hartline

Algorithmic Development, Prototyping, and Pilot Clinical Testing of a Therapy Optimization Platform to Support Healthcare Providers in the Management of Type 2 Diabetes (DSS-HCP-T2). Adaptive Behavioral Control (ABC) in a Closed-Loop System: A Randomized Crossover Clinical Trial. Artificial Pancreas - Adolescent Physiology & Psychology Longitudinal Evaluation (AP APPLE).

Trial Title: Artificial Pancreas – Adolescent Physiology & Psychology Longitudinal Evaluation (AP APPLE).
IRB-HSR#19088
PI: Dr. Mark DeBoer, MD
RC: Lianna Smith

The Center for Diabetes Technology seeks adolescents who are between 11 and less than 13 years old, going through puberty, and is living with Type 1 Diabetes for a research study.

The purpose of the study is to find out if teenagers going through puberty with Type 1 Diabetes can control their diabetes better by using an Artificial Pancreas (AP) system as compared to performing their usual diabetes care.

Your child may be eligible for this study if diagnosed with type 1 diabetes for at least 1 year, using insulin for at least six months, and their A1c is 10.0% or below (tested within the last 6 weeks).

Participation in this study will last about 2 years
You and your child will be required to attend a screening visit. There will be about 15 clinic or phone visits. About 10 of these visits can be done from your home, but there are about 4-5 visits that will require you to come to the Clinical Research Unit (CRU) at UVA.
You and your child will be trained on how to use the study devices, including a CGM and an insulin pump (if assigned).
If your child currently uses multiple daily injections (MDI) to treat his/her insulin, your child may need to use a study pump during this study.
Your child will be required to give blood and urine samples.
Your child will be required to have his/her body composition measured three times. This test will measure the percentages of fat, bone, water and muscle in your child’s body.
You and your child will be required to complete questionnaires about living with diabetes.

Study-related lab tests, study equipment and their associated supplies (e.g. CGM supplies, insulin pump (if assigned), and study phone) will be provided free of charge.

For more information, please email: Lianna Smith

Adapting Diabetes Treatment Expert Systems to Patient's Expectations and Psychobehavioral Characteristics in Type 1 Diabetes (DSS 2). A Phase I/II, Open-Arm Study Evaluating the Safety of Islet Transplant on Patients with Type 1 Diabetes.

Interested in Participating in a Trial?

Complete the form here to securely send your information to CDT staff.

Closed to Enrollment