Daniel J. Haisenleder, PhD
PRIMARY APPOINTMENT:
Associate Professor for Research, Endocrinology and Metabolism
Director, Ligand Assay and Analysis Core
CONTACT:
UVA Center for Research in Reproduction
Ligand Assay and Analysis Core Laboratory
OMS, Suhling Building, Room 6921
PO Box 800391
Telephone:434.982.3675
Laboratory fax: 434.982.0701
Email:djh2q@virginia.edu
EDUCATION AND TRAINING
- BS and MS – Eastern Michigan University
- PhD – Wayne State University
- Postdoctoral Training – University of Michigan
FUNDED PROJECTS
- NICHD R24 (R24HD102061)
RESEARCH SUMMARY
Over the past 20 years, the Ligand Core has served as the Reference Laboratory for the Fertility/Infertility Branch of NICHD and provided assay services for several multi-center clinical research projects, including the Reproductive Medicine Network. The Core also runs assays for basic and clinical investigators within UVA, most research institutions across the US, and several other countries.
- 2022, Legro, R. S., Hansen, K. R., Diamond, M. P., Steiner, A. Z., Coutifaris, C., Cedars, M. I., . . . Network, R. M. (2022). Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial. PLOS MEDICINE, 19(1). doi:1371/journal.pmed.1003883
- 2019, Wang, R., Li, W., Bordewijk, E. M., Legro, R. S., Zhang, H., Wu, X., . . . IPDMA, I. O. I. (2019). First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. HUMAN REPRODUCTION UPDATE, 25(6), 717-732. doi:1093/humupd/dmz029
- 2018, Evans-Hoeker, E. A., Eisenberg, E., Diamond, M. P., Legro, R. S., Alvero, R., Coutifaris, C., . . . Reproductive Medicine Network. (2018). Major depression, antidepressant use, and male and female fertility.. Fertility and sterility, 109(5), 879-887. doi:1016/j.fertnstert.2018.01.029,PMID: 29778387
- Sullivan-Pyke, C., Haisenleder, D. J., Senapati, S., Nicolais, O., Eisenberg, E., Sammel, M. D., & Barnhart, K. T. (2018). Kisspeptin is a new serum biomarker to discriminate miscarriage from viable intrauterine pregnancy.FERTILITY AND STERILITY, 109(1), 137-+. doi:1016/j.fertnstert.2017.09.029
- 2017, Quinn, M. M., Kao, C. -N., Ahmad, A. K., Haisenleder, D. J., Santoro, N., Eisenberg, E., . . . Network, N. I. H. N. I. C. H. D. R. M. (2017). Age-stratified thresholds of anti-Mullerian hormone improve the prediction of polycystic ovary syndrome over a population-based threshold.CLINICAL ENDOCRINOLOGY, 87(6), 733-740. doi:1111/cen.13415
- Greenwood, E. A., Cedars, M. I., Santoro, N., Eisenberg, E., Kao, C. -N., Haisenleder, D. J., . . . Inst, E. K. S. N. (2017). Antimullerian hormone levels and antral follicle counts are not reduced compared with community controls in patients with rigorously defined unexplained infertility. FERTILITY AND STERILITY, 108(6), 1070-1077. doi:1016/j.fertnstert.2017.09.015
- Yang, J. A., Song, C. I., Hughes, J. K., Kreisman, M. J., Parra, R. A., Haisenleder, D. J., . . . Breen, K. M. (2017). Acute Psychosocial Stress Inhibits LH Pulsatility and Kiss1 Neuronal Activation in Female Mice. ENDOCRINOLOGY, 158(11), 3716-3723. doi:1210/en.2017-00301
- Diamond, M. P., Legro, R. S., Coutifaris, C., Alvero, R., Robinson, R. D., Casson, P. A., . . . Network, H. D. R. M. (2017). Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 217(2). doi:1016/j.ajog.2017.04.034
- Engmann, L., Jin, S., Sun, F., Legro, R. S., Polotsky, A. J., Hansen, K. R., . . . Reproductive Medicine Network. (2017). Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype.. American journal of obstetrics and gynecology, 216(5), 493.e1-493.e13. doi:1016/j.ajog.2017.01.003,PMID: 28104402
- Xiao, S., Coppeta, J. R., Rogers, H. B., Isenberg, B. C., Zhu, J., Olalekan, S. A., . . . Woodruff, T. K. (2017). A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. NATURE COMMUNICATIONS, 8. doi:1038/ncomms14584
- 2015, Diamond, M. P., Legro, R. S., Coutifaris, C., Alvero, R., Robinson, R. D., Casson, P., . . . Network, N. I. C. H. D. R. M. (2015). Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility EDITORIAL COMMENT. OBSTETRICAL & GYNECOLOGICAL SURVEY, 70(12), 757-758. doi:1097/OGX.0000000000000275
- Kuang, H., Jin, S., Thomas, T., Engmann, L., Hansen, K. R., Coutifaris, C., . . . Network, R. M. (2015). Predictors of participant retention in infertility treatment trials. FERTILITY AND STERILITY, 104(5), 1236-+. doi:1016/j.fertnstert.2015.08.001
- Diamond, M. P., Legro, R. S., Coutifaris, C., Alvero, R., Robinson, R. D., Casson, P., . . . Network, N. I. C. H. D. R. M. (2015). Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. NEW ENGLAND JOURNAL OF MEDICINE, 373(13), 1230-1240. doi:1056/NEJMoa1414827
- Kuang, H., Jin, S., Hansen, K. R., Diamond, M. P., Coutifaris, C., Casson, P., . . . Reproductive Medicine Network. (2015). Identification and replication of prediction models for ovulation, pregnancy, and live birth in infertile women with polycystic ovary syndrome..Human reproduction (Oxford, England), 30(9), 2222-2233. doi:1093/humrep/dev182, PMID: 26202922
- Hayes, M. G., Urbanek, M., Ehrmann, D. A., Armstrong, L. L., Lee, J. Y., Sisk, R., . . . Dunaif, A. (2015). Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nature Communications, 6, 7502. doi:1038/ncomms8502,PMID: 26284813
- 2014, Legro, R. S., Brzyski, R. G., Diamond, M. P., Coutifaris, C., Schlaff, W. D., Casson, P., . . . Zhang, H. (2014). Letrozole Versus Clomiphene for Infertility in the Polycystic Ovary Syndrome EDITORIAL COMMENT. OBSTETRICAL & GYNECOLOGICAL SURVEY, 69(10), 599-601. doi:1097/01.ogx.0000456355.64379.77
- Legro, R. S., Brzyski, R. G., Diamond, M. P., Coutifaris, C., Schlaff, W. D., Casson, P., . . . Network, N. I. C. H. D. R. M. (2014). Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. NEW ENGLAND JOURNAL OF MEDICINE, 371(2), 119-129. doi:1056/NEJMoa1313517
- Legro, R. S., Brzyski, R. G., Diamond, M. P., Coutifaris, C., Schlaff, W. D., Alvero, R., . . . Rep, N. I. C. H. H. D. (2014). The Pregnancy in Polycystic Ovary Syndrome II study: baseline characteristics and effects of obesity from a multicenter randomized clinical trial. FERTILITY AND STERILITY, 101(1), 258-+. doi:1016/j.fertnstert.2013.08.056
- 2011, Haisenleder, D. J., Schoenfelder, A. H., Marcinko, E. S., Geddis, L. M., & Marshall, J. C. (2011). Estimation of Estradiol in Mouse Serum Samples: Evaluation of Commercial Estradiol Immunoassays. ENDOCRINOLOGY, 152(11), 4443-4447. doi:1210/en.2011-1501
- Burger, L. L., Haisenleder, D. J., & Marshall, J. C. (2011). GnRH pulse frequency differentially regulates steroidogenic factor 1 (SF1), dosage-sensitive sex reversal-AHC critical region on the X chromosome gene 1 (DAX1), and serum response factor (SRF): a potential mechanism for GnRH pulse frequency regulation of LH beta transcription in the rat.ENDOCRINE, 39(3), 212-219. doi:1007/s12020-011-9440-y
- 2010, Haisenleder, D. J., Burger, L. L., & Marshall, J. C. (2010). GnRH Pulse Frequency Regulates SF-1, DAX-1, and SRF Gene Expression In Vivo in the Rat..ENDOCRINE REVIEWS, 31(3). Retrieved from http://gateway.webofknowledge.com/
HAISENLEDER LAB MEMBERS
Lab Manager
