Research
Scientific investigators in our division are actively engaged in high-impact basic and clinical research programs, largely focused on diabetes/metabolism, cardiovascular endocrinology, and reproductive endocrinology.
Diabetes and metabolism research (Drs. Barrett, A. Basu, R. Basu, Brown, Farhy, Ferris, Horton, Keller, Liu, Love, and Santen):
- Insulin action on the vascular system and relationships to insulin’s metabolic actions
- Closed-loop insulin-delivery technologies (artificial pancreas) for type 1 diabetes
- Regulation of pancreatic hormone secretion including pancreatic alpha cell function
- Mechanisms of insulin signaling and insulin resistance
- Mechanisms by which cortisol plays a role in NAFLD/NASH
- Mechanisms of cognitive decline associated with diabetes
- Development of an intensive self-management program for patients with diabetes mellitus in rural, underserved areas
Cardiovascular endocrinology research (Drs. Barrett, Carey, Culver, Horton, Liu, Love, and Siragy):
- Hormonal control of blood pressure and hypertension
- Mechanisms underlying the impact of obesity on hypertension, kidney disease, and diabetes
- Biology and pathophysiology of angiotensin subtype receptors in cardiovascular system
- Insulin action on the vascular system and relationships to the vascular complications of diabetes
Reproductive endocrinology research (Drs. Kim, Haisenleder, Marshall, McCartney, and Santen):
- Causes of abnormal GnRH pulses and abnormal gonadotropin secretion in adolescent and adult polycystic ovary syndrome
- Mechanisms underlying peripubertal obesity-associated hyperandrogenemia
- Pathophysiology of polycystic ovary syndrome in women of later reproductive age
- Aromatase and role of estrogen in breast cancer