Research

Aurbach Reasearch Medical FacilityScientific investigators in our division are actively engaged in high-impact basic and clinical research programs, largely focused on diabetes/metabolism, cardiovascular endocrinology, and reproductive endocrinology.

Diabetes and metabolism research (Drs. Barrett, A. Basu, R. Basu, Brown, Farhy, Ferris, Horton, Keller, Liu, Love, and Santen):

  • Insulin action on the vascular system and relationships to insulin’s metabolic actions
  • Closed-loop insulin-delivery technologies (artificial pancreas) for type 1 diabetes
  • Regulation of pancreatic hormone secretion including pancreatic alpha cell function
  • Mechanisms of insulin signaling and insulin resistance
  • Mechanisms by which cortisol plays a role in NAFLD/NASH
  • Mechanisms of cognitive decline associated with diabetes
  • Development of an intensive self-management program for patients with diabetes mellitus in rural, underserved areas

Cardiovascular endocrinology research (Drs. BarrettCarey, Culver, Horton, Liu, Love, and Siragy):

  • Hormonal control of blood pressure and hypertension
  • Mechanisms underlying the impact of obesity on hypertension, kidney disease, and diabetes
  • Biology and pathophysiology of angiotensin subtype receptors in cardiovascular system
  • Insulin action on the vascular system and relationships to the vascular complications of diabetes

Reproductive endocrinology research (Drs. Kim, Haisenleder, MarshallMcCartney, and Santen):

  • Causes of abnormal GnRH pulses and abnormal gonadotropin secretion in adolescent and adult polycystic ovary syndrome
  • Mechanisms underlying peripubertal obesity-associated hyperandrogenemia
  • Pathophysiology of polycystic ovary syndrome in women of later reproductive age
  • Aromatase and role of estrogen in breast cancer