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Research

UVA EndocrinologyScientific investigators in our division actively engage in high-impact basic and clinical research programs, primarily focused on diabetes/metabolism, cardiovascular endocrinology, and reproductive endocrinology.

Diabetes and metabolism research (Drs. Brown, Farhi, Ferris, Horton, Keller, Liu, and Love):

  • Insulin action on the vascular system and relationships to insulin’s metabolic actions
  • Closed-loop insulin-delivery technologies (artificial pancreas) for type 1 diabetes
  • Regulation of pancreatic hormone secretion, including pancreatic alpha cell function
  • Mechanisms of insulin signaling and insulin resistance
  • Mechanisms by which cortisol plays a role in NAFLD/NASH
  • Mechanisms of cognitive decline associated with diabetes
  • Development of an intensive self-management program for patients with diabetes mellitus in rural, underserved areas

Cardiovascular endocrinology research (Drs. Culver, Horton, Liu, Love, and Siragy):

  • Hormonal control of blood pressure and hypertension
  • Mechanisms underlying the impact of obesity on hypertension, kidney disease, and diabetes
  • Biology and pathophysiology of angiotensin subtype receptors in the cardiovascular system
  • Insulin action on the vascular system and relationships to the vascular complications of diabetes

Reproductive endocrinology research (Drs. Burt-Solorzano, Haisenleder):

  • Causes of abnormal GnRH pulses and abnormal gonadotropin secretion in adolescent and adult polycystic ovary syndrome
  • Mechanisms underlying peripubertal obesity-associated hyperandrogenemia
  • Pathophysiology of polycystic ovary syndrome in women of later reproductive age
  • Aromatase and the role of estrogen in breast cancer

ENDOCRINE INVESTIGATORS

Our clinical faculty members have a wide range of clinical and research interests, and the division has active research programs with state-of-the-art facilities. Please explore the links below to discover the research in some of our Endocrine labs.