Helmy M. Siragy, MD, FACP, FAHA

Siragy Helmy MD


Professor of Medicine and Endocrinology
University of Virginia
Charlottesville, Virginia

Dr. Helmy Siragy is a Professor of Medicine in the Division of Endocrinology and Metabolism and a member of the Cardiovascular Research Center at the University of Virginia Health System in Charlottesville, Virginia, where he is also an attending physician at the University of Virginia Hospital.

Dr. Siragy obtained his residency training at the University of Texas Medical Branch in Galveston, TX, followed by fellowships in Endocrinology and Hypertension under Professor Frederic C. Bartter at the University of Texas Health Sciences Center in San Antonio. Dr. Siragy is board certified in internal medicine, specializing in endocrinology, diabetes, and metabolism. He is also certified as Hypertension Specialist by the American Society of Hypertension.

Dr. Siragy is a fellow of the American College of Physicians and the American Heart Association and is a member of numerous national and international Endocrine and Hypertension Societies. He is a reviewer for the American Heart, National Institute of Health Study Sections, and several national and international medical journals. He sets on the editorial board of The Journal of Hypertension, the official journal of the International Society of Hypertension. He is the Section Editor for the Antihypertensive Agents: Mechanisms of Drug Action section, Current Hypertension Reports.

An international lecturer on subjects related to hypertension and endocrinology, Dr. Siragy was the first to discover and publish that stimulation of angiotensin AT2 receptor leads to the generation of nitric oxide through stimulation of Bradykinin-Nitric Oxide-cGMP cascade.

Dr. Siragy has authored more than 150 medical journal articles and twenty-one medical textbook chapters, including the chapter on the kidney and the renin-angiotensin system in Braunwald Atlas of Heart Diseases, Angiotensin and Diabetic Nephropathy in Harrison’s online textbook of Medicine and The Angiotensin Receptor: AT1


Helmy M. Siragy, M.D.
Department of Internal Medicine, Box 801409
University of Virginia Health System
450 Ray C Hunt Drive
Charlottesville, VA 22902

Office: (434) 924-5629
Lab: (434) 924-9661
Fax: (434) 982-3626


Dr. Siragy’s Lab

Photo of Dr. Helmy SiragyDr. Helmy M. Siragy developed the microdialysis technique, which led to a Golden Age of revolutionary discoveries about the nature of angiotensin receptors and renal paracrine hormones.

The lab focuses on the biology and pathophysiology of angiotensin subtype receptors in the cardiovascular system. Currently, the lab is conducting pioneering translational research that has a major clinical impact and is related to cardiac ischemia, diabetic kidney disease, local tissue production of aldosterone, and its paracrine functions in the kidney and heart.

Photo of William Pitkin working in Siragy LabThe Lab is also involved in clinical studies related to aldosterone pulse activity in normal individuals and patients with primary aldosteronism, vasopressin receptors in kidneys, and management of hyponatremia, and one of our ongoing studies investigating the effects of long-term angiotensin subtype one receptor blockade on cardiovascular morbidity and mortality.

Dr. Siragy’s lab is located in the Fontaine Research Park, just off the US29/250 Bypass, in the Aurbach Medical Research Building.

Research Funding

  • NIH/NHLBI R01 HL09153518 (7/14/2017 – 6/30/2021)
  • NIH/NHLBI R01 DK11487504 (8/17/2017 – 5/31/2021)


Here are some organizations that Dr. Siragy is associated with: