Susanna R. Keller, MD

PRIMARY APPOINTMENT:

• Associate Professor of Medicine, Endocrinology and Metabolism (primary)
• Associate Professor of Cell Biology (secondary)

CONTACT:

Aurbach Building Room 2322
450 Ray C Hunt Drive
Charlottesville VA 22903
Email: srk4b@virginia.edu

RESEARCH AREAS:

• Insulin signaling and regulation of nutrient metabolism and energy homeostasis
• Metabolic disease-associated cardiovascular complications
• Hormone-regulated membrane trafficking and relevance to whole-body physiology

PUBMED

• Graduate: M.D. (Dr. Med.) University of Zurich, Switzerland
• Research Fellow: Metabolic Unit, University of Zurich, Switzerland
• Postdoctoral Fellow: Dartmouth Medical School, Biochemistry, Hanover NH

• NIH/NHLBI R01 HL128189 (1/1/2021 – 12/31/2024)

A major interest of the Keller laboratory has been to investigate insulin signaling and the regulation of the trafficking of membrane proteins, the glucose transporter GLUT4, and the insulin-regulated aminopeptidase IRAP in primary adipocytes and skeletal muscles, and to study how insulin, by promoting cell surface localization of GLUT4 and IRAP in adipocytes and muscles, affects whole-body nutrient metabolism and energy homeostasis. Recent research examined the roles of two Rab GTPase activating proteins (Rab GAPs), AS160 (Tbc1d4) and Tbc1d1, in the regulation of glucose uptake in primary adipocytes and skeletal muscles and the control of whole-body glucose, lipid, and energy homeostasis using knockout mice and primary adipocytes and skeletal muscles isolated from these.

Recently, Dr. Keller took the lead of a collaborative research project investigating molecular mechanisms by which the renal angiotensin receptor type 2 (AT₂R) regulates sodium excretion and blood pressure. We use rat models of hypertension and proximal tubule-specific AT₂R knockout mice to delineate pathways controlling AT₂R trafficking to the apical surface of renal proximal tubule cells, identify AT₂R signaling intermediates that promote sodium excretion, and uncover defects in AT₂R trafficking and signaling that contribute to the development of hypertension.

In long-term research collaborations with other investigators at the University of Virginia, Dr. Keller is involved in evaluating the effects of genetic background on metabolic responses to various diets, elucidating the role of adenosine receptors in metabolic homeostasis, identifying metabolic defects preceding hypertension-induced left ventricular hypertrophy and heart failure, and investigating the role of metabolic disease in the development of atherosclerosis. The research in the Keller laboratory is relevant to major metabolic diseases (metabolic syndrome, obesity, and diabetes) and associated cardiovascular complications.

• David Brautigan PhD, Professor Emeritus of Pharmacology
• Robert Carey MD MCAP, Professor and Dean Emeritus, Department of Medicine-Division of Endocrinology and Metabolism
• Mete Civelek PhD, Associate Professor of Biomedical Engineering and Resident Faculty in the Department of Genome Sciences
• Heather Ferris, MD PhD, Assistant Professor of Medicine, Endocrinology and Metabolism
• John Gildea PhD, Research Scientist, Department of Pathology
• Thurl Harris PhD, Associate Professor of Pharmacology
• Sibylle Kranz PhD RDN, Associate Professor of Kinesiology
• Bijoy Kundu PhD, Associate Professor of Radiology and Medical Imaging
• Gary Owens PhD, Professor of Cardiovascular Research, Department of Molecular Physiology and Biological Physics