Zhenqi Liu, MD
PRIMARY APPOINTMENT:
- James M. Moss Professor of Diabetes
- Professor of Medicine
- Past Chief (2012 – 2021), Division of Endocrinology and Metabolism
TRAINING:
- Graduate: M.D., Hunan Medical University
- Internal Medicine Residency: Washington Hospital Center, Washington, DC
- Endocrinology Fellowship: University of Virginia, Charlottesville, VA
- Endocrinology Research Fellowship: Yale University (New Haven, CT) and University of Virginia (Charlottesville, VA)
RESEARCH INTERESTS:
My laboratory has long been interested in insulin action in health and diabetes. Currently, the primary focus is on regulating insulin action in the vasculature and its relation to insulin’s metabolic action and the cardiovascular complications of diabetes. We use a variety of rodent models and cultured cells to study the mechanisms of insulin action and conduct clinical research studies in humans with or without diabetes to see how insulin’s vascular actions are regulated in humans with or without insulin resistance and diabetes.
Prospective new fellows could focus on regulating insulin’s vascular and metabolic actions by GLP-1 receptor activation, SGLT2 inhibition, or exercise in health and diabetes.
Our research has been supported by the NIH and the American Diabetes Association. Ongoing research support includes:
- NIH/NIDDK R01DK125330 (7/1/2020 – 4/30/2025): Effects of exercise and GLP-1R agonism on muscle microvascular perfusion and insulin action – Principal Investigator
- NIH/NIDDK R01DK124344 (4/1/2021 – 3/31/2026): Role of microvascular insulin resistance and cardiorespiratory fitness in diabetes – Principal Investigator (MPI)
- NIH/NIDDK R01HL129510 (7/1/2021 – 6/30/2024): Modulation of ghrelin release by exercise intensity: The role of obesity and prediabetes status – Co-investigator (PI: A Weltman)
- NIH/NHLBI R01HL142250 (12/1/2018 – 11/30/2022): Acute effects of hyperglycemia on the heart and skeletal muscle microvasculature – Co-investigator (PI: E Barrett)
- NIH/NIDDK R01 DK116768 (01/10/2019 – 12/31/2022): Genetic connections between type 2 diabetes and atherosclerosis – Co-investigator (PI: W Shi)