6/17/2025
Our lab is interested in the molecular and cellular basis of human disease, with a focus on aberrant signal transduction of protein kinases in ciliopathies, a class of human diseases…
6/17/2025
The goal of my research is to understand the mechanistic underpinnings of the cell signaling network that contribute to cancer progression and resistance to therapy. My laboratory is currently focused…
6/17/2025
As Paleolithic hunter gatherers, the human diet was relatively low in fats and simple carbohydrates. Technological advances, beginning with the agricultural revolution 12,000 years ago and culminating with the mechanization…
6/17/2025
Introduction: Mitochondria are often pictured in biology texts as static, individual organelles, when in reality they form highly dynamic and mobile networks constantly undergoing fusion and fission. Research in the last…
6/17/2025
Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus Kaposi's sarcoma (KS) remains one of the two most common AIDS-associated malignancies and is caused by the human herpesvirus, KSHV, first discovered in 1994. Nevertheless,…
6/17/2025
Lungs are more immunogenic than other organ and tissue grafts. In the clinical setting, combined heart lung transplants have demonstrated the rapid onset of lung rejection. Recent work in our…
6/17/2025
Dr. Landen's research focus is on novel therapeutics and chemotherapy resistance in gynecologic cancers, primarily ovarian cancer. He conducts preclinical and clinical research developing models to better-understand the pathways contributing…
6/17/2025
Targeted therapy: by serendipity, we identified a novel oncogene, and found that multiple cancers are addicted to its activity. This oncogene addiction is evidenced in glioblastoma, pediatric sarcoma, and others.…
6/17/2025
UNLEASH: We work on cytokine control of memory lymphocytes, with a particular interest in the molecular regulators of vaccination and pathological antibodies in different disease states. Experimentally, we use i) mouse…
6/17/2025
Genomic analysis of primary human cancer specimens for global genetic and gene expression alterations. Development of model systems to validate biological roles of candidate genes. Translation of experimental findings to…
