6/17/2025
Dr. Ragosta is the principal or co-principal investigator on numerous multi-center clinical trials, including the EXCEL trial (left main PCI VS CAB6) and both the PARTNER trail (trans-catheter aortic valve…
6/17/2025
1) Activation of blood vessel smooth muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Most recently my laboratory has been interested in contractile mechanisms beyond…
6/17/2025
Cell signaling networks coordinate a wide variety of cellular physiology and gene regulatory programs. Perturbations in these signaling networks contribute to the pathogenesis of many diseases, including cardiovascular disease, cancer…
6/17/2025
The main focus of the Scheld research laboratory is the pathogenesis and pathophysiology of serious bacterial infections. Early work focused on endocarditis and bacterial meningitis. The latter resulted in scores…
6/17/2025
Understanding how gene expression is regulated in response to signals from both inside and outside the body plays a critical role in allowing us to adapt to changes in the…
6/17/2025
The long-term goal of our research is to identify and produce novel therapeutic agents, which have the potential of translation from bench to bedside. Our major interest lies in autoimmune…
6/17/2025
My primary research interest is in atherosclerosis, which is the cause of heart attack, stroke and peripheral arterial disease. Although mortality from atherosclerosis has had a decline in past few…
6/17/2025
An international expert on subjects related to hypertension, Dr. Siragy was the first to discover that stimulation of angiotensin AT2 receptor leads to generation of nitric oxide. Siragy has authored…
6/21/2025
Our research focuses on the molecular basis of smooth muscle contraction, the role of RhoA GTP exchange factors (GEFs) and GTP activating proteins (GAPs) in smooth muscle signaling, and identifying…
