6/17/2025
Our research focus is to understand the structure and function of unusual DNA sequences in living cells, and how these sequences cause genome instability and lead to human diseases. Human…
6/17/2025
Many diseases of the nervous system (both neurodevelopmental and neurodegenerative) as well as degenerative and regenerative processes after injury can be traced at the cellular level to disruptions of endolysosomal…
6/17/2025
Our mission is to understand how signaling molecules mediate cardiomyocyte growth, hypertrophy, and heart failure. We use novel approaches based on fruit fly genetics to identify genes that cause or…
6/17/2025
Research in my lab focuses on advancing knowledge of how the human immune system responds to environmental triggers that worsen lung disease. The prevalence of asthma has risen dramatically in…
6/17/2025
The cardiovascular system is the first organ system to form in vertebrates and it is essential for embryonic survival. This system continually grows and remodels to meet the increasing energetic…
6/17/2025
Our lab has worked in several areas involving viral pathogenesis, host responses to infection, understanding immunogenicity, the control of viral gene expression and viral latency, and vaccine development. Recently, the…
6/17/2025
My laboratory is interested in understanding the pathogenetic mechanism of Huntington's disease (HD). HD is a dominantly inherited neurodegenerative disorder that affects about 1 in 10,000 people in the United…
6/17/2025
To treat cancer effectively, great efforts have been devoted to molecularly targeted therapy. While there have been great examples of success, cancer cells often develop drug resistance to evade therapy.…
6/17/2025
Research in our laboratory is focused on discovering the mechanisms that control stem cell fate. Specifically, we seek to identify factors that control the progression and branch points of cellular…
6/17/2025
There are two research focuses in my laboratory: the regulation of glutamate transporters and neuroprotection. Glutamate is a major excitatory neurotransmitter. Glutamate is also a toxin when its extracellular concentration…
