6/17/2025
Our laboratory studies macromolecular structures with an aim toward an in-depth understanding of structure-function relationships. X-ray diffraction analysis is our primary research tool, but we also employ other physical and…
6/17/2025
My laboratory focuses on understanding the molecular and epigenetic mechanisms involved in the regulation of normal hematopoiesis and hematologic malignancies. The ultimate goal of our research is to identify new…
6/17/2025
Our research focuses on the development and optimization of magnetic resonance imaging techniques, particularly those for rapid and three-dimensional imaging, drawing on a variety of physics and engineering principles, with…
6/17/2025
Tyrosine phosphorylation is a protein modification that can occur during or after translation of a protein.The phosphate addition to a tyrosine residue, regulated by tyrosine kinases and phosphatases, can result…
11/13/2025
All organisms carefully control the concentration of solutes within their cells, and are able to import required compounds or exclude cytotoxic ones. The protein machines that carry out these tasks…
6/17/2025
All the way up to the 20th century, the human genome has been optimized to survive in environments characterized by fluctuations between periods of feast and famine. These survivor-genomes clash…
6/17/2025
My laboratory is interested in innate and adaptive immunity in acute and chronic kidney injury. Dendritic cells play an early role in activation of lymphocytes through antigen presentation of peptides…
6/17/2025
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or StrokeAtherothrombosis, resulting from rupture or…
6/17/2025
Systems analysis has become a requirement for making sense of high-throughput data and for characterizing properties of biological networks. In order to extend these recent developments to medical applications, there…
6/17/2025
Much of our work focuses on cell signaling and mechanisms of lineage specification, differentiation and morphogenesis. Particular emphases have been on post-embryonic neural crest stem cells and their derivatives, including…
