6/17/2025
In every human cell, dynamic cytoskeletal networks drive or enable critical processes such as cell division, motility, and secretion. Cytoskeletal dysregulation consequently results in cellular malfunction and several pathologies, ranging…
6/17/2025
We aim to understand how eukaryotic cells control chromatin structure. Knowledge of chromatin-structure at the level of its nucleosome subunits inside cells will give far-reaching mechanistic insight into gene regulation,…
6/17/2025
In humans, internalization of extracellular and plasma membrane-localized cargo through clathrin-independent endocytosis or CIE has been implicated in multiple diseases including various forms of cancers and Alzheimer’s disease. However, we…
6/17/2025
The etiology of many cardiovascular diseases can be traced to the microcirculation, which is the primary focus of the Isakson lab. For example, high blood pressure as well as strokes…
6/17/2025
My lab investigates the molecular mechanisms that control how cells manage protein biogenesis and adapt to stress, with broad implications for human disease. 1. Cell Dormancy – We study the…
6/17/2025
Research Description One of the major goals of my research program is to understand the role of membrane microdomains such as lipid rafts and caveolae in health and disease. We address…
2/28/2026
I am interested in understanding the molecular basis of vascular inflammation in disease conditions such as hypertension, Obesity, and Lung Ischemia-Reperfusion Injury.
6/17/2025
SERCA2a [the Ca-ATPase of sarcoplasmic reticulum (SR) of cardiac muscle] plays a central role in intracellular calcium dynamics and thus in the contractility of the heart. The SR regulates the…
