6/17/2025
Current funded projects in the laboratory: (1) Elucidation of molecular mechanisms controlling smooth muscle contractility; (2) Development of drugs against the influenza and Ebola viruses; (3) Studies of the mechanism of protein crystallization…
6/17/2025
In every human cell, dynamic cytoskeletal networks drive or enable critical processes such as cell division, motility, and secretion. Cytoskeletal dysregulation consequently results in cellular malfunction and several pathologies, ranging…
6/17/2025
Structural biology of membrane proteins: Membrane proteins represent about ~25% of all proteins in any given genome carrying out many vital functions (transporters, receptors, channels, etc..). Membrane proteins also represent ~50%…
6/17/2025
We aim to understand how eukaryotic cells control chromatin structure. Knowledge of chromatin-structure at the level of its nucleosome subunits inside cells will give far-reaching mechanistic insight into gene regulation,…
6/17/2025
In humans, internalization of extracellular and plasma membrane-localized cargo through clathrin-independent endocytosis or CIE has been implicated in multiple diseases including various forms of cancers and Alzheimer’s disease. However, we…
6/17/2025
There are two morphologically distinct forms of the HIV-1 virus, called immature and mature. The immature virion is the form that initially assembles and initiates budding from the plasma membrane.…
6/17/2025
The etiology of many cardiovascular diseases can be traced to the microcirculation, which is the primary focus of the Isakson lab. For example, high blood pressure as well as strokes…
6/17/2025
- Quality Control of Protein Targeting to the Endoplasmic Reticulum - Protein Targeting and Import into Mitochondria
