6/27/2025
Atherosclerosis is a chronic inflammatory disease whose late-stage clinical complications including myocardial infarction (heart attack) and stroke, are the leading causes of death worldwide. Clinical trials of anti-inflammatory therapies yield…
6/17/2025
The post-genomic era is marked by the development of technologies which have revealed the astonishing molecular diversity of gene products. Multiple distinct protein forms, or “proteoforms”, can arise through several…
6/17/2025
1. Inflammation and remodeling in asthma (Human and animal) a. Role of chemokines receptor 2 in inflammation and immunologic tolerance b. Obesity and asthma 2. Pathogenesis of COPD: Role of…
6/17/2025
Repair of the stereocilia actin core (project leader: Elizabeth Wagner) Hair bundles are complex structures that have to be maintained throughout the life of the organism, because mature mammalian hair cells…
6/17/2025
Transcriptional silencing Understanding how chromatin structure influences DNA-mediated processes has become a fundamental problem in cellular biology. Chromatin is known to influence the regulation of eukaryotic gene expression, DNA replication, DNA…
6/17/2025
The Spencer lab studies host-pathogen interactions of Gram-positive bacteria, focusing on the major neonatal pathobiont Group B Streptococcus (GBS). GBS can asymptomatically colonize the female genital tract, leading to transmission…
6/17/2025
We are interested in understanding how neurons and epithelia develop the asymmetric shapes and subcellular organization, which enable their physiological functions. We focus on cytoskeleton-based mechanisms, and how they malfunction…
12/6/2025
My research program in the Department of Pharmacology at the University of Virginia focuses on understanding how adipose tissue dysfunction, metabolic signaling, and immune–stromal interactions drive human disease, and on…
6/17/2025
Defects in chromosome segregation can generate aneuploidy, a condition that is found in almost all human tumors and is the major cause of miscarriages and birth defects. The complex process…
6/17/2025
Agnieszka Swiatecka-Urban studied the regulation of cell-surface stability and intracellular trafficking of membrane proteins in epithelial cells. One focus of her research activity has been the characterization of mechanisms and…
