6/17/2025
Research Interests: Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes. 1. Resolution of acute and propagation of chronic inflammation. 2. Mechanisms of endothelial-monocyte interaction in chronic…
6/17/2025
The overall goal of our research is to understand the fundamental mechanisms by which membranes and dietary lipids regulate cell physiology. By understanding the cell biology of lipids and membranes,…
6/17/2025
Investigating the brain networks underlying human pain perception through intracranial recordings, EEG, and computational modeling. Basic neuroscience discoveries are translated into targeted clinical trials for deep brain stimulation and focused…
6/17/2025
1. Wnt and PCP signaling in mechanosensory hair cell polarity. The actin-based hair bundle atop sensory hair cells is the mechanotransduction organelle essential for hearing and balance. A majority of sensorineural…
6/17/2025
6/17/2025
Our laboratory studies macromolecular structures with an aim toward an in-depth understanding of structure-function relationships. X-ray diffraction analysis is our primary research tool, but we also employ other physical and…
6/17/2025
11/13/2025
All organisms carefully control the concentration of solutes within their cells, and are able to import required compounds or exclude cytotoxic ones. The protein machines that carry out these tasks…
6/17/2025
Systems analysis has become a requirement for making sense of high-throughput data and for characterizing properties of biological networks. In order to extend these recent developments to medical applications, there…
6/17/2025
The Patel lab focuses on understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13). SCN8A EE is a severe genetic epilepsy syndrome caused by de…
