6/17/2025
Our goal is to understand the molecular mechanisms by which cells move, with particular emphasis on muscle contraction. We examine the mechanics of these processes at the level of individual…
6/17/2025
Biological processes ranging from gene transcription to behavior oscillate and are synchronized to the 24-hour day/night cycle. Mammalian circadian rhythms, orchestrated by the hypothalamic suprachiasmatic nucleus (SCN) allow appropriately timed…
6/17/2025
Many mammalian and viral genes are alternatively spliced and subject to regulation at the post- transcriptional level. However, relatively little is known about the cellular mechanisms for this regulation. We…
6/17/2025
As Paleolithic hunter gatherers, the human diet was relatively low in fats and simple carbohydrates. Technological advances, beginning with the agricultural revolution 12,000 years ago and culminating with the mechanization…
6/17/2025
Living cells and tissues adapt to their environment by altering structure, gene and protein expression, and biochemical functions. For example, endothelial cells lining the artery wall at the blood tissue…
6/17/2025
Diagnostic ultrasound - image processing, quantification Molecular imaging using ultrasound Catheter-based ultrasound Ultrasound-based drug/gene delivery Ultrasound image guided therapy
6/17/2025
The etiology of many cardiovascular diseases can be traced to the microcirculation, which is the primary focus of the Isakson lab. For example, high blood pressure as well as strokes…
6/17/2025
Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus Kaposi's sarcoma (KS) remains one of the two most common AIDS-associated malignancies and is caused by the human herpesvirus, KSHV, first discovered in 1994. Nevertheless,…
6/17/2025
Advancement in the design of imaging agents has many far-reaching implications for the future directions of molecular imaging and radiological sciences including the following: (1) The early detection of disease…
6/17/2025
A. Personal Statement I am an active, practicing vascular surgeon who has also maintained an independently funded basic science/translational research laboratory since 2003. My clinical practice is focused on the care…
