Christopher Moore, MD

Christopher C. Moore is a physician-scientist. He received his BS in Biology from the University of North Carolina-Chapel Hill and his MD from Mercer University School of Medicine. He completed his clinical training in internal medicine and fellowship in infectious diseases at the University of Virginia. 

He has dedicated his research career to the study of critical illness. Specifically, he has investigated the pathophysiology, microbiological causes, and outcomes of sepsis in murine models and clinical patient cohorts. Through his study of A2A adenosine receptor agonists, he found that modulation of the innate immune system response during sepsis improved outcomes in murine models. 

His clinical studies and evaluations of infectious diseases in sub-Saharan Africa include modeling the clinical phenotypes associated with sepsis from over 6,000 hospitalized patients in the region. In southwestern Uganda, he investigated malaria’s role in adult sepsis using high-resolution melt (HRM) analysis from blood smears. In collaboration with Mbarara University of Science and Technology, Moore and his colleagues have worked to monitor critically ill patients better and improve outcomes. This work led to NIH-supported randomized clinical trials to find a diagnosis and treatment for patients with sepsis and HIV in Tanzania and Uganda.

At CAMA, Moore applies statistical modeling and ML learning to help identify patients at risk for bloodstream infection. He is the founding member of the African Sepsis Alliance and formerly served as director of the infectious diseases fellowship program at UVA.