Shrirang Gadrey, MBBS, MPH

Shri Gadrey is an internal medicine specialist. He received his M.B.B.S. in Medicine from The Seth G.S. Medical College and K.E.M. Hospital and his M.P.H. in Public Health from Johns Hopkins Bloomberg School of Public Health. Dr. Gadrey completed his Internal Medicine Residency at Georgetown University. 

How clinicians can assess breathing and how that assessment informs medical decision-making are central to Dr. Gardrey’s work. Impacted by experiences of abrupt clinical deterioration as a hospitalist, Dr. Gadrey was inspired to improve ways physicians could anticipate and prevent a patient’s collapse. His interest in novel predictive monitoring systems and ideas to improve the measurement of pathophysiology led him to leave his private practice in 2016 to join CAMA and a faculty appointment at the University of Virginia, where he is the Director of Research for the Division of General, Geriatric, Palliative and Hospital Medicine and Associate Professor Medicine. 

Dr. Gardrey developed the Analysis of Respiratory Kinematics technology (A.R.K.) to address a critical gap in existing respiratory monitoring systems and their inability to quantity labored breathing patterns in any clinical setting. Using wearable motion sensors, the A.R.K. systems quantify breathing motion patterns with high fidelity and, in a study of 108, improved the prediction of critical illness beyond standard predictors. Dr. Gadrey derived a novel measure for hypoxia severity by applying an oxygen-dissociation curve model to non-invasively estimate the P/F ratio from pulse oximetry (SpO2) called ePFR. In a multi-retrospective cohort of patients hospitalized with COVID-19, he found that the ePFR outperformed multi-organ dysfunction models.