The Biorepository and Tissue Research Facility (BTRF) provides access to high-quality, pathologically-characterized fresh, snap frozen, or formalin- fixed paraffin embedded (FFPE) human cancer tissue and associated benign tissue by prospective procurement, maintaining a frozen tissue biobank, and access to clinical Pathology tissue archives. This facility is the processor of human biofluids in support of clinical trials and biobanking for UVA investigators. It also provides standard and advanced histology services including paraffin embedding, paraffin sectioning, cryostat sectioning, staining and microdissection, tissue microarray manufacture, whole slide digital imaging, and digital image analysis. In addition, this facility also provides tissue-based molecular analysis techniques, including single- and multi-color immunohistochemistry, RNA in-situ hybridization and spatial transcriptomics and spatial proteomic analysis. Expert histopathology support from Board-certified Anatomic Pathologists is provided for these activities through this Shared Resource.