6/17/2025
All eukaryotic cells divide by assembling a microtubule-based spindle machinery that equally segregates chromosomes between daughter cells. The faithful segregation of chromosomes during cell division is essential as errors in…
6/17/2025
Cell signaling networks coordinate a wide variety of cellular physiology and gene regulatory programs. Perturbations in these signaling networks contribute to the pathogenesis of many diseases, including cardiovascular disease, cancer…
6/17/2025
The post-genomic era is marked by the development of technologies which have revealed the astonishing molecular diversity of gene products. Multiple distinct protein forms, or “proteoforms”, can arise through several…
6/17/2025
The Sonkusare laboratory studies the role of ion channels and calcium signaling mechanisms in regulating vascular function and blood pressure. Constriction of small arteries is a crucial determinant of blood…
6/17/2025
Defects in chromosome segregation can generate aneuploidy, a condition that is found in almost all human tumors and is the major cause of miscarriages and birth defects. The complex process…
6/17/2025
Summary: Nano-electromagnetics (NEMS)--Signaling at the nano/bio interface: The measurement, analysis and propagation of electrical, magnetic and optical signals with nanoscale spatial resolution is of interest within biomolecular sensing, morphogenesis, tissue regeneration,…
6/17/2025
Our lab studies the structure and function of several membrane proteins of clinical importance in their natural membrane environment. We are also interested in the roles that membrane lipids play…
6/17/2025
Our research focuses on the molecular mechanisms of mitochondrial calcium transport and signaling. We aim to understand how these mitochondrial processes contribute to cardiovascular and neuronal physiology, as well as…
6/17/2025
Analytical Neurochemistry I am interested in the development and characterization of analytical techniques to measure neurochemical changes. Measurements in the brain are challenging because zeptomole quantities of neuroactive molecules must be…
6/17/2025
The primary focus of our work is to develop a fundamental understanding of the mechanisms that govern the formation of multinucleated cell types produced by cell-cell fusion – making one…
