6/17/2025
Targeted therapy: by serendipity, we identified a novel oncogene, and found that multiple cancers are addicted to its activity. This oncogene addiction is evidenced in glioblastoma, pediatric sarcoma, and others.…
6/17/2025
Epigenetic changes accompany an individual’s development, aging, and disease. They’re particularly significant markers for cancer’s onset and progression, posing substantial therapeutic challenges. Increasing evidence suggests that DNA replication stress leads…
6/17/2025
1. Wnt and PCP signaling in mechanosensory hair cell polarity. The actin-based hair bundle atop sensory hair cells is the mechanotransduction organelle essential for hearing and balance. A majority of sensorineural…
6/17/2025
Our laboratory is focused on understanding how immunological pathways contribute to neurodegenerative, neurodevelopmental, mental and behavior disorders. We are actively investigating the cellular and molecular pathways that contribute to neuroinflammation…
6/17/2025
Our research investigates the biology of the lipid mediator, sphingosine 1-phosphate (S1P). S1P concentration gradients are known to influence immune cell positioning. Indeed, S1P type 1 receptor agonist drugs are…
6/17/2025
My research lies in the areas of statistical genetics and genetic epidemiology with an emphasis on 1) analysis of genome-wide association studies in the multi-ethnic cohort studies, 2) gene-based analysis…
6/17/2025
Within cells there exists a fine balance between survival and death. One of the earliest steps in the development of cancer is the ability of a cell to escape death.…
6/17/2025
My laboratory's research focus involves the application of modern genomics and bioinformatics approaches to unravel complex and rare cardiovascular diseases. By integrating large-scale human genetic association and whole genome sequencing…
6/17/2025
My laboratory focuses on understanding the molecular and epigenetic mechanisms involved in the regulation of normal hematopoiesis and hematologic malignancies. The ultimate goal of our research is to identify new…
